在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEPD Antibody, Biotin conjugated

  • 中文名稱:
    PEPD兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA017784LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PEPD Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEPD
  • 別名:
    Aminoacyl L proline hydrolase antibody; Imidodipeptidase antibody; MGC10905 antibody; MGC95081 antibody; Pep 4 antibody; Pep4 antibody; pepD antibody; PEPD_HUMAN antibody; Peptidase 4 antibody; Peptidase D antibody; Prolidase antibody; Proline dipeptidase antibody; X pro dipeptidase antibody; X-Pro dipeptidase antibody; Xaa-Pro dipeptidase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Xaa-Pro dipeptidase protein (258-395AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
  • 基因功能參考文獻:
    1. PEPD directly binds to p53 in the nucleus and cytoplasm and suppresses both transcription-dependent and transcription-independent activities of p53, which does not require PEPD enzymatic activity. PMID: 29233996
    2. Increased serum prolidase activity and decreased antioxidant levels are likely to be a results of increased of oxidative stress levels in obese subjects PMID: 28867357
    3. Serum prolidase activity is reduced in scleroderma patients, especially in diffuse form. PMID: 28534076
    4. Increased levels of serum prolidase activity are associated with the severity of developmental dysplasia of the hip. PMID: 27320745
    5. High resolution X-ray crystallographic models of substrate and product binding in the active site of human prolidase. PMID: 28677335
    6. We report here that by introducing either the A252R or P365R substitution mutation, the structural changes affecting catalytic turnover rate and substrate binding affinity are valuable in improving the catalytic activity of human prolidase towards toxic organophosphorus compound hydrolysis. PMID: 28462712
    7. In ankylosing spondylitis, serum prolidase level was successful in measuring disease activity PMID: 27443556
    8. there is an independent relationship of aortic prolidase activity and aortic prolidase immunostaining with aortic stiffness beta index in patients who underwent coronary artery bypass grafting PMID: 27387023
    9. Prolidase activity decreases in patients with chronic obstructive pulmonary disease. PMID: 26870880
    10. absence of prolidase activity in pterygium tissue indicates that there is no collagen turnover in this tissue PMID: 26509313
    11. Decreased serum prolidase activity may be associated with knee osteoarthritis PMID: 25994092
    12. The association between the PEPD genetic variant and the risk of T2D was modulated by n-3 fatty acids. Higher n-3 fatty acids may abolish the adverse effect of the risk allele at PEPD for T2D PMID: 26087900
    13. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control. PMID: 26159719
    14. Levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. PMID: 26078578
    15. Serum prolidase level was significantly higher in schizophrenia patients compared to the controls. PMID: 25842545
    16. There may be an ethnic- and/or sex-specific association of the PEPD rs731839 single nucleotide polymorphism and serum lipid levels in Mulao and Han populations PMID: 25120796
    17. Prolidase is required for early trafficking events during influenza A virus entry. PMID: 25031340
    18. High prolidase activity may indicate critical biological activities relevant to pathological events in Behcet's disease, and this activity may be a biological indicator of disease. PMID: 24225260
    19. Significantly lower prolidase activity in patients with benign joint hypermobility syndrome suggests that prolidase may affect the collagen metabolism and cause hyperlaxity. PMID: 24612543
    20. Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis. PMID: 24484408
    21. Suggest prolidase as a high affinity ligand of the ErbB2 receptor which can regulate ErbB2 signaling and cell growth. PMID: 24810047
    22. Patients with psoriasis exhibit higher serum prolidase activity independent of gender, BMI, disease severity or duration, type of treatments or nitric oxide level. PMID: 23553128
    23. Data suggest that elevated serum prolidase activity and oxidative stress may be associated with increased cardiovascular risk in polycystic ovary syndrome (PCOS) and/or menstrual irregularities associated with this syndrome. PMID: 23163753
    24. Prolidase dependent HIF1A expression in breast cancer cells is induced by prolidase substrate peptides. PMID: 23549681
    25. prolidase may share an undefined role in fibrosis in heart failure and may have a role in the diffuse fibrosis of heart failure. PMID: 24065222
    26. Serum PEPD activity appears to be higher in patients with diabetic foot ulcers when compared with patients without diabetic foot ulcers and healthy controls. PMID: 23242638
    27. kinetic and structural evidences on human prolidase pathological mutants PMID: 23516557
    28. Varicose venous wall prolidase enzyme activity could be an important factor in progression of azoospermia and infertility in patients with varicocele. PMID: 23171426
    29. PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation PMID: 23212918
    30. A diminished prolidase activity may contribute to alteration of collagen metabolism and should be considered a biomarker of myeloproliferative neoplasms progress. PMID: 23457135
    31. Although approximately 70 PEPD gene mutations and polymorphisms have been reported in various ethnic groups, we however report, for the first time, the identification of insertion mutation in human the PEPD gene. PMID: 23287645
    32. A Mn(II)-Mn(II) center in human prolidase. PMID: 22999980
    33. Assessed the serum prolidase enzyme level and the oxidative-antioxidative status in chronic hepatitis C infection. The prolidase was higher in the chronic hepatitis C group compared to the control group. PMID: 22811354
    34. Increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer. PMID: 22258852
    35. Relinoic acid regulates prolidase activity in human dermal cells via IGF receptor signaling in photoaged cells. PMID: 22245250
    36. elevated in submucosal uterine fibroids PMID: 22185542
    37. Serum prolidase activity is elevated in patients with pulmonary tuberculosis PMID: 21722016
    38. Prolidase activity was positively correlated erum prolidase activity is significantly associated with Legg-Calve-Perthes disease. PMID: 21304409
    39. In the early pregnancy loss group compared to the control group, serum levels of prolidase activity were significantly lower and placental tissue activity levels were significantly higher. PMID: 20437180
    40. investigation of role of prolidase in regulation of expression of TGF beta1 & TGF beta1 receptor in skin fibroblasts: down-regulation by prolidase inhibitors (Cbz-Pro & PEP); up-regulation by prolidase products (Pro & HyPro) PMID: 20868675
    41. Serum prolidase activity seems to be correlated with the level of fibrosis in patients with non-alcoholic steatohepatitis. PMID: 20486204
    42. found serum prolidase activity was significantly lower in both Idiopathic and ischemic dilated cardiomyopathies (DCM) groups relative to healthy volunteers and lower in ischemic DCM than idiopathic. PMID: 20626024
    43. Data suggest that the presence of ascending aortic aneurysms is associated with low serum prolidase activity. PMID: 20383038
    44. Data shows prolidase activity was significantly increased in patients with thalassemia major compared with controls. PMID: 20087956
    45. FAK-independent regulation of prolidase activity and collagen biosynthesis in MCF-7 cells. PMID: 11820613
    46. Carbobenzoxyproline is a potent inhibitor of prolidase in cultured fibroblasts from patients with prolidase deficiency. PMID: 15878628
    47. Significant correlation was observed between serum prolidase activity, and total antioxidant capacity, total oxidant status and oxidative stress index (p<0.01, r=-0.367; p<0.05, r=0.283; p<0.01, r=0.379; respectively) in H. pylori-positive subjects. PMID: 16999949
    48. oxidative stress and decreased prolidase activity may have a role in pathogenesis of knee osteoarthritis PMID: 17096092
    49. Prolidase is viable target for selective activation of melphalan prodrugs in melanoma cells. PMID: 17377743
    50. Prolidase deficiency and systemic lupus erythematosus share a number of common immunological features. PMID: 17570078

    顯示更多

    收起更多

  • 相關疾病:
    Prolidase deficiency (PD)
  • 蛋白家族:
    Peptidase M24B family, Eukaryotic-type prolidase subfamily
  • 數據庫鏈接:

    HGNC: 8840

    OMIM: 170100

    KEGG: hsa:5184

    STRING: 9606.ENSP00000244137

    UniGene: Hs.36473



主站蜘蛛池模板: 日本又色又爽又黄的a片吻戏| 2021久久最新国产精品| 亚洲综合在线一区二区三区| 国产特级毛片aaaaaa高清| 日日噜噜夜夜爽爽| 欧美一区内射最近更新| 视频在线+欧美十亚洲曰本| 亚洲午夜无码久久久久小说| 亚洲日韩色欲色欲com| 99久热re在线精品99 6热视频| 337p粉嫩日本欧洲亚洲大胆| 18禁真人抽搐一进一出在线| 亚洲乱码中文字幕综合234| 丰满亚洲大尺度无码无码专线| 久久亚洲春色中文字幕久久久 | 国偷自产视频一区二区久| 污污内射在线观看一区二区少妇| 亚洲精品久久久久中文第一幕 | 99国产精品久久久久久久成人热| 少妇饥渴xxhd麻豆xxhd骆驼| 久久9精品区-无套内射无码| 日韩精品无码免费专区午夜不卡| 欧美日韩精品一区二区在线视频 | 高潮射精日本韩国在线播放| 300部国产真实乱| 97se亚洲国产综合自在线观看| 亚洲人成人伊人成综合网无码| 欧美巨大xxxx做受中文字幕| 我把护士日出水了视频90分钟| 欧美人与动牲交xxxxbbbb| 免费看美女部位隐私网站| 国产乱人伦av在线麻豆a| 久久无码人妻一区二区三区午夜 | 欧美极品video粗暴| 国产美女被遭高潮免费网站| 亚洲另类色区欧美日韩图片| 性欧美丰满熟妇xxxx性仙踪林| 在线 | 一区二区三区| 欧美精品黑人粗大| 午夜无码人妻av大片色欲| 一区二区三区在线 | 网站|