在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEMT Antibody, FITC conjugated

  • 中文名稱:
    PEMT兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA017780LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PEMT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEMT
  • 別名:
    PEMT; PEMPT; PNMT; Phosphatidylethanolamine N-methyltransferase; PEAMT; PEMT; PEMT2; Phospholipid methyltransferase; PLMT
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphatidylethanolamine N-methyltransferase protein (2-49AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).
  • 基因功能參考文獻:
    1. Study found three gene variants (CLOCK-rs4864548, PEMT-rs936108, and GHRELIN-rs696217) that exhibited uncorrected gene-by-sleep duration interactions in relation to BMI z-scores in a cohort of New Zealand European children. However, no interactions were identified in percentage body fat differences. Notably, these interactions are evident without detectable effects on sleep duration. PMID: 28899534
    2. In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342). PMID: 27677362
    3. Results showed that PEMT mRNA expression in liver tissues of non-alcoholic steatohepatitis (NASH) patients was significantly lower than those with simple steatosis suggesting a distinct clinical entity of lean NASH with insufficiency of PEMT activities. PMID: 26883167
    4. a significant association between the PEMT rs7946 A-allele and a risk of nonalcoholic fatty liver disease, with the effect being more prominent in East-Asians, but not in non-Asians (Meta-Analysis) PMID: 26636496
    5. Data show that phosphatidylethanolamineN-methyltransferase (PEMT) rs12325817 polymorphism only marginally changed the association value with academic achievement. PMID: 26728177
    6. Data suggest that maternal dietary intake during lactation (here, choline intake exceeding dietary recommendations) can alter hepatic PEMT activity and increase choline content of breast milk. PMID: 26025328
    7. MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high risk of type 2 diabetes in Han Chinese. PMID: 25074646
    8. The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes. PMID: 23794489
    9. PEMT is a functional single nucleotide polymorphism (rs7946) in PEMT with sporadic Alzheimer's disease risk in a Han Chinese population. PMID: 21881829
    10. the PEMT -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality PMID: 22387881
    11. genetic association studies on endometriosis in a population of women in Poland: Data suggest interaction between an SNP in PEMT (rs4244593) and an SNP in MTHFR (Ala222Val; rs1801133) in infertile women with some indication of endometriosis. PMID: 21429654
    12. nvestigation of factors affecting liver PEMT activity: PEMT activity is lower in liver samples from women who are homozygous for an SNP in PEMT (rs12325817) PMID: 21411618
    13. allele-specific ablation of estrogen receptor-DNA interaction in the PEMT locus prevents hormone-inducible PEMT expression, conferring risk of choline deficiency in women PMID: 21059658
    14. Choline requirements for both women are increased by the genetic polymorphism rs12325817 in phosphatidylethanolamine-N-methyltransferase. PMID: 20861172
    15. Total intake of choline and genotype can influence the concentrations of choline and its metabolites in the breast milk and blood of lactating women and thereby affect the amount of choline available to the developing infant. PMID: 20534746
    16. The allele frequency of PEMT did not show a significant difference between normal control group and fatty liver patients (P=0.222). PMID: 19262398
    17. an examination of the membrane topography of this enzyme PMID: 12431977
    18. PEMT2 mRNA expression was inversely related to tumor proliferation and to histologic grade. PMID: 12931022
    19. PEMT-mediated Hcy secretion correlated with the methyltransferase activity of the enzyme, independently of subcellular localization PMID: 15927961
    20. Val175Met variant of PEMT could be a susceptibility candidate to nonalcoholic steatohepatitis (NASH), because it is more frequently observed in NASH patients and non-obese persons with Val175Met variant of PEMT are facilitated to develop NASH PMID: 17391797
    21. Human PEMT genes have three unique transcription start sites, which are indicative of either multiple promoters and/or alternative splicing. PMID: 17456783
    22. The present results suggest that the PEMT gene may contribute to the etiology of schizophrenia. PMID: 17720317
    23. single nucleotide polymorphisms of choline-metabolizing genes, PEMT -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk PMID: 18230680
    24. These data suggest that polymorphisms in PEMT genes relevant to choline metabolism modulate parameters of choline status when folate intake is restricted. PMID: 19167960
    25. in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma homocysteine PMID: 19211833
    26. No association of the rs4646396 SNP in the PEMT locus with schizophrenia in a Chinese case-control sample. PMID: 19647326

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Class VI-like SAM-binding methyltransferase superfamily, PEMT/PEM2 methyltransferase family
  • 數據庫鏈接:

    HGNC: 8830

    OMIM: 602391

    KEGG: hsa:10400

    STRING: 9606.ENSP00000255389

    UniGene: Hs.714193



主站蜘蛛池模板: 青青久在线视观看视| 久久婷婷五月综合色一区二区 | 亚洲加勒比无码一区二区| 国产av无码专区亚洲awww| 99热成人精品热久久6网站 | 中文字幕日韩人妻无码| 高潮毛片无遮挡高清免费| 偷看农村女人做爰毛片色| 欧美性群另类交| 成人三级无码视频在线观看| 国产亚洲精品无码成人| 99久久99久久久精品齐齐综合色圆 | 久久精品中文闷骚内射| 久久国产福利一区二区| 国产精品人妻熟女男人的天堂| 大陆极品少妇内射aaaaaa| 亚洲va无码专区国产乱码 | 亚洲国产精品无码久久青草| 国产成人8x人网站视频在线观看| 亚洲成av人片一区二区梦乃| 国产毛a片啊久久久久久保和丸| 欧美级特黄aaaaaa片| 亚洲人成日韩中文字幕无卡| 97久久精品人人澡人人爽| 久久九九精品99国产精品 | 暖暖的在线观看日本社区| 精品无码国产自产在线观看水浒传| 日本边添边摸边做边爱的网站| 欧美高清性色生活片免费观看| 无码国产片观看| 国产精品成人免费视频网站京东| 热re99久久精品国产66热| 国产美女被遭强高潮网站下载| 天堂资源在线官网| 少妇粉嫩小泬喷水视频www| 99蜜桃在线观看免费视频网站| 亚洲精品无码成人aaa片| 欧美熟妇性xxx交潮喷| 色哟哟国产精品免费观看| 国产 校园 另类 小说区| 中文字幕亚洲一区二区三区|