在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEG10 Antibody

  • 中文名稱:
    PEG10兔多克隆抗體
  • 貨號:
    CSB-PA768203LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA768203LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA768203LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PEG10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEG10
  • 別名:
    AA407948 antibody; Edr antibody; Embryonal carcinoma differentiation regulated antibody; Embryonal carcinoma differentiation-regulated protein antibody; HB 1 antibody; HB1 antibody; KIAA1051 antibody; Mammalian retrotransposon-derived protein 2 antibody; Mar2 antibody; Mart2 antibody; MEF3 like 1 antibody; MEF3-like protein 1 antibody; MEF3L antibody; MEF3L1 antibody; MyEF 3 antibody; Myelin expression factor 3-like protein 1 antibody; Paternally expressed 10 antibody; Paternally expressed gene 10 ORF1 antibody; Paternally expressed gene 10 protein antibody; Peg10 antibody; PEG10 protein antibody; PEG10_HUMAN antibody; Putative uncharacterized protein PEG10 antibody; Retrotransposon gag domain containing 3 antibody; Retrotransposon gag domain-containing protein 3 antibody; Retrotransposon-derived gag-like polyprotein antibody; Retrotransposon-derived protein PEG10 antibody; RGAG3 antibody; Ty3/Gypsy-like protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Retrotransposon-derived protein PEG10 protein (1-325AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PEG10 Antibody (CSB-PA768203LA01HU),的標記方式是Non-conjugated。對于PEG10 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA768203LB01HU PEG10 Antibody, HRP conjugated ELISA
    FITC CSB-PA768203LC01HU PEG10 Antibody, FITC conjugated
    Biotin CSB-PA768203LD01HU PEG10 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
  • 基因功能參考文獻:
    1. PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors. PMID: 29727698
    2. Results demonstrated that an increased expression of PEG10 is associated vessel invasion, and the overall survival time of PC patients. E2F-1 mediated PEG10 overexpression promotes pancreatic cancer (PC) cell proliferation via accelerating cell cycle progression and increase migration and invasion through ERK/MMP7 pathway. These results suggest that PEG10 may serve as an oncogene in PC pathogenesis. PMID: 28193232
    3. miR-122 suppresses PEG10 expression via direct binding to the 3'-UTR of the PEG10 transcript. PMID: 27370270
    4. PEG10 expression associates with the lymph node metastasis and overall survival of hepatocellular carcinoma patients.PEG10 expression level is essential for TGF-beta1 induced epithelialmesenchymal transition. PMID: 28004118
    5. Knockdown of PEG10 expression by siRNA could lead to growth arrest and cell apoptosis in diffuse large B cell lymphoma cells in vitro. PMID: 25864113
    6. PEG10 protein could be a potential biomarker predicting early recurrence and recurrence-free survival in HCC patients after curative resection, even in those with normal serum alpha-fetoprotein levels. PMID: 25687862
    7. Study shows that expression level of PEG10 was significantly elevated in breast cancer tissues and associated with distant metastasis and poor clinical outcome and provides evidence that PEG10 is a crucial oncogene. PMID: 26934961
    8. important role in trophoblast proliferation and promotes trophoblast invasion through TIMP-1 PMID: 26680220
    9. Results revealed that PEG10 high expression was closely associated with the TNM classification in lung cancer and is a critical indicator for poor prognosis. Also, It promotes significantly proliferation, migration and invasion of A549 lung cancer cells. PMID: 25199998
    10. The downregulated expression of the imprinted gene PEG10 may be an important reason for the occurrence of preeclampsia. PMID: 25526181
    11. elevated expression of PEG10 is likely to be involved in the pathophysiology of preeclampsia PMID: 22137777
    12. promotes migration of Burkitt's lymphoma cells via upregulation of matrix metalloproteinase-2 and -9 PMID: 22673314
    13. Overexpression of PEG10 and TSG101 was detected in gallbladder adenocarcinoma. PMID: 21455631
    14. PEG10 imprinting is lost in a majority of hepatocellular carcinomas and no correlation exists between the imprinting status of PEG10 and its expression in HCC tissues. PMID: 21205473
    15. the mRNA expression level of PEG10 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts. PMID: 21767414
    16. In third trimester PEG10 was downregulated in fetal samples group PMID: 20484977
    17. PEG10 gene is imprinted, with preferential expression from the paternal allele. PMID: 11318613
    18. miR-122 may be involved in regulation of PEG10 expression hepatoma cell lines. PMID: 20460050
    19. study provides new data on the genomic organization as well as expression and translation of PEG10, a prerequisite in order to study and understand the role of PEG10 in cancer, embryonic development and normal cell homeostasis PMID: 20084274
    20. Evidence for translation initiation from an in-frame, upstream non-AUG (CUG) codon, and from the downstream AUG, resulting in different isoforms. PMID: 20084274
    21. PEG10 is a probable target, acting as a driving force for amplification of the 7q21 region, and may therefore be involved in the development or progression of hepatocellular carcinomas. PMID: 20362226
    22. placental PEG10 is downregulated at early hypoxic phase, and highly activated at 11-12 wk of gestation PMID: 12620933
    23. Exogenous expression of PEG10 conferred oncogenic activity. PEG10 protein associated with SIAH1, a mediator of apoptosis, and overexpression of PEG10 decreased the cell death mediated by SIAH1. PMID: 12810624
    24. Results indicate that the induction of the imprinted gene paternally expressed 10 (PEG10) may play an important role during liver regeneration or carcinogenesis of the human hepatocyte. PMID: 14576465
    25. Data show that CXCL13 and CCL19 together by means of activation of CXCR5 and CCR7 up-regulated PEG10 expression and function in leukemic B cells. PMID: 16225771
    26. PEG10 is a direct target of c-MYC; findings link cancer genetics and epigenetics by showing that a classic proto-oncogene, MYC, acts directly upstream of a proliferation-positive imprinted gene, PEG10 PMID: 16423995
    27. PEG10 represents a novel marker in B-cell chronic lymphocytic leukemia PMID: 17621626
    28. the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals PMID: 17942406
    29. The results showed that maintaining sufficient levels of PEG10 may be important during early pregnancy. Lower levels of PEG10 might be one of reasons that underlie inevitable abortion. PMID: 18550496
    30. The expression profile of hepatocelluar carcinoma tissues suggested E2Fs were involved in PEG10 regulation. PMID: 18625225
    31. PEG10 contains two overlapping reading frames from which two proteins are translated by a -1 ribosomal frameshift mechanism. PMID: 15611116
    32. Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes. PMID: 15767280

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ACVRL1.
  • 組織特異性:
    Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level).
  • 數據庫鏈接:

    HGNC: 14005

    OMIM: 609810

    KEGG: hsa:23089

    STRING: 9606.ENSP00000417587

    UniGene: Hs.147492



主站蜘蛛池模板: 欧美又大粗又爽又黄大片视频| 亚洲人成未满十八禁网站| 免费特级黄毛片| 97se亚洲国产综合在线| 国产成人啪精品视频网站| 亚洲腹肌男啪啪网站男同| 亚洲高清偷拍一区二区三区| 天天摸天天碰天天添| 国产欧美二区综合| 夜夜添无码试看一区二区三区| 精品无码国产自产拍在线观看 | 亚洲精品www久久久久久 | 亚洲精品在看在线观看高清 | 国产午夜福利精品一区二区三区| 久久亚洲中文字幕精品一区| 久久久精品中文字幕乱码18| 亚洲情综合五月天| 中文无码一区二区不卡av| 办公丝袜av一区二区三区| 国产美女精品视频线播放| 国模吧无码一区二区三区| 久久精品国产亚洲一区二区| 日本熟妇hdsex视频| 伦埋琪琪久久影院三级| 日产中文字幕在线观看| 免费无码久久成人影片| 亚洲一卡2卡3卡4卡5卡精品| 一个人在线观看免费视频www| 狠狠色丁香婷婷综合潮喷| 四虎亚洲精品高清在线观看| 自拍偷自拍亚洲精品牛影院| 丰满人妻熟妇乱又伦精品| 永久免费观看的毛片手机视频| 亚洲日本精品国产一区vr| 亚洲日韩乱码中文无码蜜桃臀| 蜜桃av色偷偷av老熟女| 久久激情综合狠狠爱五月| 国产免费一区二区三区在线观看 | 久久久一本精品99久久精品66直播| 人人妻人人澡人人爽精品欧美| 国内精品伊人久久久久7777|