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  4. PDZRN3 Antibody, Biotin conjugated

PDZRN3 Antibody, Biotin conjugated

  • 中文名稱：
    PDZRN3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA891797LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PDZRN3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDZRN3
  • 別名：
    E3 ubiquitin-protein ligase PDZRN3 antibody; KIAA1095 antibody; Ligand of Numb protein X 3 antibody; likely ortholog of mouse semaF cytoplasmic domain associated protein 3 antibody; LNX3 antibody; PDZ domain containing ring finger 3 antibody; PDZ domain-containing RING finger protein 3 antibody; Pdzrn3 antibody; Protein SEMACAP3 antibody; PZRN3_HUMAN antibody; SEMACAP3 antibody; Semaphorin cytoplasmic domain associated protein antibody; Semaphorin cytoplasmic domain-associated protein 3 antibody; SEMCAP3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
  • 基因功能參考文獻：
    1. Authors show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the papillomavirus life cycle and differentiation-related STAT signaling. PMID: 25355882
    2. a novel partner of Kidins220/ARMS PMID: 22609016
    3. These results indicate that PDZRN3 plays an important role in negative feedback control of BMP-2-induced osteoblast differentiation in C2C12 cells through inhibition of Wnt3a-beta-catenin signaling. PMID: 20668165
  • 亞細胞定位：
    Cell junction, synapse. Cytoplasm.
  • 組織特異性：
    Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
  • 數據庫鏈接：

    HGNC: 17704

    OMIM: 609729

    KEGG: hsa:23024

    STRING: 9606.ENSP00000263666

    UniGene: Hs.660347



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