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PDZD2 Antibody

  • 中文名稱:
    PDZD2兔多克隆抗體
  • 貨號:
    CSB-PA008313
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PDZD2
  • 別名:
    PDZD2 antibody; AIPC antibody; KIAA0300 antibody; PDZK3 antibody; PDZ domain-containing protein 2 antibody; Activated in prostate cancer protein antibody; PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human PDZK3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. we systematically evaluating RCC risk-associated SNPs indentified from previous GWAS in a Chinese population, finding that one SNP located in PDZD2 and two SNPs located in ITPR2 were ccRCC-risk associated in Chinese population. PMID: 26918600
    2. The DNA copy number variations disrupt PDZD2 and GOLPH3 genes predominantly expressed in placenta, and it may represent a novel risk factor for recurrent miscarriage. PMID: 24827138
    3. This study does not support the association of PDZD2, GOLPH3, and MTMR12 genes with schizophrenia. PMID: 21451436
    4. the first reported multi-PDZ protein that is processed by proteolytic cleavage to generate a secreted peptide containing two PDZ domains PMID: 12671685
    5. The mitogenic effect of secreted PDZD2 was concentration-dependent, and was associated with a slight inhibition of the insulin promoter activity at high sPDZD2 concentrations. PMID: 16413998
    6. Results show that a novel pancreatic developmental factor, PDZD2, is sufficient to promote the proliferation of human fetal PPCs while limiting differentiation of ICCs into islet/endocrine cells. PMID: 18037333
    7. sPDZD2 sensitized mutant p53-positive DU145 cells and wild-type p53-positive MCF-7 cells to apoptosis induction through genotoxic stress imposed by sub-lethal concentration of hydrogen peroxide PMID: 18639375
    8. PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization. PMID: 19046020

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  • 亞細胞定位:
    Nucleus. Cytoplasm. Endoplasmic reticulum.; [Processed PDZ domain-containing protein 2]: Secreted.
  • 組織特異性:
    Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.
  • 數據庫鏈接:

    HGNC: 18486

    OMIM: 610697

    KEGG: hsa:23037

    STRING: 9606.ENSP00000282493

    UniGene: Hs.481819



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