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  4. PDS5A Antibody, Biotin conjugated

PDS5A Antibody, Biotin conjugated

  • 中文名稱：
    PDS5A兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA643713LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PDS5A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDS5A
  • 別名：
    Cell proliferation inducing protein 54 antibody; Cell proliferation-inducing gene 54 protein antibody; KIAA0648 antibody; PDS5; regulator of cohesion maintenance; homolog A (S. cerevisiae) antibody; PDS5A antibody; PDS5A_HUMAN antibody; PIG54 antibody; SCC-112 antibody; SCC112 antibody; Sister chromatid cohesion protein 112 antibody; Sister chromatid cohesion protein PDS5 homolog A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sister chromatid cohesion protein PDS5 homolog A protein (2-134AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
  • 基因功能參考文獻：
    1. These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis PMID: 27549371
    2. By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. PMID: 26051894
    3. The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication. PMID: 21865657
    4. Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells. PMID: 21069257
    5. Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation. PMID: 15019998
    6. SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling. PMID: 17846787

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    PDS5 family
  • 組織特異性：
    Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
  • 數據庫鏈接：

    HGNC: 29088

    OMIM: 613200

    KEGG: hsa:23244

    STRING: 9606.ENSP00000303427

    UniGene: Hs.331431



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