在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDK4 Antibody, FITC conjugated

  • 中文名稱:
    PDK4兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA614983LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDK4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDK4
  • 別名:
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 antibody; FLJ40832 antibody; mitochondrial antibody; Pdk4 antibody; PDK4_HUMAN antibody; Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial antibody; Pyruvate dehydrogenase kinase 4 antibody; Pyruvate dehydrogenase kinase isoenzyme 4 antibody; Pyruvate dehydrogenase kinase isoform 4 antibody; Pyruvate dehydrogenase kinase isozyme 4 antibody; Pyruvate dehydrogenase kinase isozyme 4 mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial protein (143-333AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
  • 基因功能參考文獻:
    1. Results show that PDK4-specific 5'UTR DNA methylation is positively associated with eicosapentaenoic and arachidonic acid in adult males. PMID: 27181711
    2. it was found that low expression of FAM210B was significantly correlated with decreased survival and enhanced metastasis in vivo and in vitro, and the loss of FAM210B led to an increased mitochondrial respiratory capacity and reduced glycolysis through the downregulation of pyruvate dehydrogenase kinase 4 (PDK4). PMID: 28594398
    3. In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD. PMID: 29128353
    4. Low PDK4 expression is associated with lung tumorigenesis. PMID: 27641336
    5. Increased PDK4 expression is associated with colon cancer. PMID: 28208156
    6. We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation PMID: 27456128
    7. Inhibition of CK2 increased the expression of metabolic regulators, PDK4 and AMPK along with the key cellular energy sensor CREB. PMID: 27001465
    8. These findings indicate that the TGFbeta/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy. PMID: 27330076
    9. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins. PMID: 28003426
    10. FXR may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch. PMID: 26728993
    11. Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha and PDK4 mRNA response in trained human muscle. PMID: 27456910
    12. High PDK4 expression is associated with hepatocellular cancer. PMID: 26506419
    13. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification. PMID: 26560812
    14. Fatty acids induce the expression of PDK4 mRNA, which was increased in myotubes cultured from obese and T2DM donors. PMID: 25311062
    15. Swiss PDB Viewer identifies NFkappaB subunit p100/p49 as a potential interacting partner for PDK4. Relationship between PDK4 and apoptosis is suggested. PMID: 25794976
    16. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 expression PMID: 25609694
    17. Methylation increased in PDK4, IL1 B, IL6, and TNF promoters 12 months after gastric bypass. PMID: 24837562
    18. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade. PMID: 25164809
    19. Data show that the orphan nuclear receptor estrogen related receptor gamma (ERRgamma) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression. PMID: 23050013
    20. mRNA of PGC-1alpha and PDK4 increases markedly in both type I and type II skeletal muscle after either continuous or interval exercise PMID: 21883960
    21. PDK4 polymorphisms may not be associated with type 2 diabetes or metabolic syndrome. PMID: 22019269
    22. The present structures demonstrate the flexible and dynamic aspects of PDK4 in the open conformation and provide a basis for the development of novel inhibitors targeting the nucleotide-binding pocket of PDK4. PMID: 21904029
    23. PDK4 gene is downregulated in colic adenocarcinoma. PMID: 20715114
    24. The expression of the pyruvate dehydrogenase kinase 4 was downregulated in the failing heart. PMID: 12145475
    25. results support the concept that a reduced tissue availability of fatty acids consequent to a massive lipid malabsorption influences glucose metabolism acting through the regulation of pyruvate dehydrogenase kinase 4 PMID: 12582211
    26. mRNA levels are increased in skeletal muscle during fasting PMID: 14966024
    27. Expression of constitutively active PKB alpha abrogates dexamethasone stimulation of hPDK4 promoter activity. PMID: 15047604
    28. Gene expression regulation is affected by retinoic acid and histone acetyation (review). PMID: 15581486
    29. activation of FXR may suppress glycolysis and enhance oxidation of fatty acids via inactivation of the pyruvate dehydrogenase complex by increasing PDK4 expression PMID: 15721319
    30. retinoic acids (RA) as well as Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), regulate PDK4 gene expression PMID: 16757381
    31. Accumulation of im lipids plays a more important role than impaired activation of Akt-mediated pathways in the regulation of muscle PDK4 gene expression in lipid-induced acute insulin-resistant states PMID: 17652214
    32. PDK4 upregulation in adipocytes participates in the hypolipidemic effect of thiazolidinediones through modulation of glyceroneogenesis PMID: 18519799
    33. PDK4 with bound ADP exists in equilibrium between the open and the closed conformations PMID: 18658136

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    PDK/BCKDK protein kinase family
  • 組織特異性:
    Ubiquitous; highest levels of expression in heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8812

    OMIM: 602527

    KEGG: hsa:5166

    STRING: 9606.ENSP00000005178

    UniGene: Hs.8364



主站蜘蛛池模板: 18禁无遮挡免费视频网站| 日本边添边摸边做边爱的网站| 超碰97人人做人人爱亚洲尤物| 中国女人内谢69xxxx视频| 图片区小说区av区| 亚洲精品av一二三区无码 | 99热这里只有精品免费播放| 久久精品国产亚洲不av麻豆| 免费午夜无码片在线观看影院| 亚洲第一无码精品立川理惠| 无码少妇一区二区浪潮av| 98久久人妻少妇激情啪啪| 性欧美激情aa片在线播放| 又大又硬又爽免费视频| 天堂网www最新版官网| 国产素人在线观看人成视频| 国内精品伊人久久久久影院麻豆| 精品国产日韩亚洲一区| 狠狠色噜噜狠狠狠888777米奇| 人妻aⅴ无码一区二区三区| 中文字幕人妻互换av久久| 国产午夜精品一二区理论影院| 天天爽夜夜爽夜夜爽| 婷婷丁香五月中文字幕| 精品国产一区二区三区久久久狼| 色综合亚洲一区二区小说| 欧美又大又粗午夜剧场免费| 亚洲国产成人精品无码区99| 最新日韩精品中文字幕| 欧美成 人 在线播放视频 | 亚洲另类欧美在线电影| 免费看成人午夜福利专区| 欧洲熟妇色 欧美| 无码中文字幕日韩专区视频| 人成午夜免费视频无码| 久久无码超清激情av| 日本久久综合久久综合 | 5858s亚洲色大成网站www| 日韩放荡少妇无码视频| 国产亚洲另类无码专区| 色欲色香天天天综合网站|