在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PDK2 Antibody

PDK2 Antibody

  • 中文名稱：
    PDK2兔多克隆抗體
  • 貨號：
    CSB-PA266329
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA266329(PDK2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 antibody; mitochondrial antibody; PDHK2 antibody; PDK2 antibody; PDK2_HUMAN antibody; Pyruvate dehydrogenase kinase isoform 2 antibody; Pyruvate dehydrogenase kinase, isozyme 2 antibody; Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human PDK2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
  • 基因功能參考文獻：
    1. PDK2/PARL senses defects in mitochondrial bioenergetics. PMID: 28178523
    2. The data demonstrate potential roles of PDK2 and ABCG2 polymorphisms in the metabolic phenotypes of Tibetan gout patients. PMID: 26909964
    3. High glycolysis and PDK2 overexpression are closely linked to cisplatin resistance in head and neck cancer cells, which can be reversed by PDK2 nhibition. PMID: 26607904
    4. The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2-dependent mechanism that switches Bnip3 from cell death to survival. PMID: 26416963
    5. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2. PMID: 24356970
    6. Germline mutations in PKD2 gene is associated with autosomal-dominant polycystic kidney disease. PMID: 23300259
    7. we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS/AMPK-dependent activation of PDK. PMID: 23376776
    8. Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer. PMID: 22614004
    9. Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species. PMID: 22910903
    10. Results established that wild-type p53 prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 suppresses tumorigenesis acting at the level of cancer cell metabolism. PMID: 22123926
    11. PKD2 mutations are associated with autosomal dominant polycystic kidney disease. PMID: 21115670
    12. study of facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase PMID: 12816949
    13. The increased PDK activity was independent of changes in intra-mitochondrial effectors, and PDK-2 and PDK-4 protein content, suggesting that it was caused by a change in the specific activity of the existing kinases. PMID: 15169745
    14. A mechanism for pyruvate dehydrogenase kinase isoform 2 regulation is supported in which kinase activity is limited by ADP dissociation and pyruvate binding. PMID: 15491150
    15. Reductive acetylation stimulates activity of pyruvate dehydrogenase kinase isoform 2 by speeding up ADP dissociation. PMID: 15491151
    16. in human muscle, hormonal and nutritional conditions may control PDK2 and PDK4 mRNA expression via a common signalling mechanism. PMID: 15955060
    17. Crystallographic studies reveal several PDHK2 structures with C-terminal cross arms that span a large trough region between the N-terminal regulatory (R) domains of the PDHK2 dimers. Three novel ligand binding sites are located in the R domain of PDHK2. PMID: 16401071
    18. analysis of ligand induced effects on pyruvate dehydrogenase kinase isoform 2 PMID: 16517984
    19. These studies identify ORP9 as a PDK-2 substrate and negative regulator of Akt phosphorylation at the PDK-2 site. PMID: 16962287
    20. PDK2, PDK3 and PDK4 are primary PPARbeta/delta target genes in humans underlining the importance of the receptor in the control of metabolism PMID: 17669420
    21. Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2. PMID: 18220414
    22. Pi is suggested to facilitate transmission within PDHK2 of the stimulatory signal of acetylation from the distal lipoyl-group binding site to the active site. PMID: 18220415
    23. mitochondrial ND2 mutation contributes to HIF1alpha accumulation via increased ROS production, up-regulation of PDK2, attenuating PDH activity, thereby increasing pyruvate, resulting in HIF1alpha stabilization PMID: 19147752
    24. PKD1 children have more and larger renal cysts, larger kidneys and higher ambulatory BP than do PKD2 children. PMID: 19194729
    25. the DW-motif has a pivotal role in mediating communications between the DCA-, the nucleotide-, and the lipoyl domain-binding sites of PDK2 PMID: 19833728

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    PDK/BCKDK protein kinase family
  • 組織特異性：
    Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.
  • 數據庫鏈接：

    HGNC: 8810

    OMIM: 602525

    KEGG: hsa:5164

    STRING: 9606.ENSP00000420927

    UniGene: Hs.256667



主站蜘蛛池模板： 人妻无码熟妇乱又伦精品视频| 亚洲熟伦熟女新五十路熟妇| 少妇粉嫩小泬喷水视频www| 女人18毛片水真多| 欧美激情综合色综合啪啪五月| 人人做人人爽国产视 | 国产69精品久久久久孕妇| 亚洲成av人最新无码| 毛片免费视频观看| 亚洲精品无码久久久久久久| 亲子乱av一区二区三区| 亚洲精品乱码一区二区三区| 国产成人精品自在线拍| 色狠狠色狠狠综合天天| 香蕉久久一区二区三区啪啪| 一个色综合国产色综合| 色94色欧美sute亚洲线路一| 日本中文一区二区三区亚洲| 农民人伦一区二区三区| 日韩人妻无码一区二区三区综合部 | 亚洲精品国男人在线视频| 无码人妻h动漫中文字幕| 少女韩国电视剧在线观看完整| 亚洲精品自偷自拍无码| 俺去啦俺来也五月天| 国精产品一区一区三区免费视频| 国产精品久久午夜夜伦鲁鲁| 成人综合婷婷国产精品久久| 美女黄频视频大全免费的国内| 国产精品美女乱子伦高潮| 久久人妻少妇嫩草av| 少妇特黄a一区二区三区| 精品无码日韩一区二区三区不卡| 国产69精品久久久久乱码| 久久国产亚洲高清观看| 色偷偷亚洲男人本色| 亚洲精品久久久久中文第一幕| 国产在线午夜不卡精品影院| 国产美女精品视频线免费播放| 欧美乱大交xxxxx潮喷l头像| 仙踪林果冻传媒一区二区|