在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDIA6 Antibody

  • 中文名稱:
    PDIA6兔多克隆抗體
  • 貨號:
    CSB-PA622988DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: PDIA6 antibody at 5.9µg/ml
      Lane 1: Mouse heart tissue
      Lane 2: Mouse lung tissue
      Lane 3: Mouse liver tissue
      Lane 4: 293T whole cell lysate
      Lane 5: Hela whole cell lysate
      Lane 6: HL60 whole cell lysate
      Lane 7: HepG2 whole cell lysate
      Lane 8: THP-1 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 54, 48 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA622988DSR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDIA6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Endoplasmic reticulum protein 5 antibody; ER protein 5 antibody; ERp5 antibody; P5 antibody; Pdia6 antibody; PDIA6_HUMAN antibody; Protein disulfide isomerase A6 antibody; Protein disulfide isomerase associated 6 antibody; Protein disulfide isomerase family A member 6 antibody; Protein disulfide isomerase P5 antibody; Protein disulfide isomerase related protein antibody; Protein disulfide-isomerase A6 antibody; Thioredoxin domain containing 7 (protein disulfide isomerase) antibody; Thioredoxin domain containing protein 7 antibody; Thioredoxin domain-containing protein 7 antibody; TXNDC7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Protein disulfide-isomerase A6 protein (20-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
  • 基因功能參考文獻:
    1. Results indicate that protein disulfide isomerase family 6 (PDIA6) overexpression promoted the proliferation of HeLa cells by suppressing the phosphorylation of beta-catenin, thereby inhibiting the degradation of beta-catenin through the ubiquitin-proteasome pathway. PMID: 27462866
    2. the chaperone 78-kDa glucose-regulated protein (GRP78) protects the MPD against PDI-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition. PMID: 28949004
    3. Downregulation of PDIA6 inhibited BC cell proliferation and invasion in vitro as well as tumor growth and metastasis in vivo. In addition, PDIA6 downregulation suppressed the Wnt/beta-catenin signaling pathway. PMID: 27760590
    4. Results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6. PMID: 28866093
    5. ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head. PMID: 26676989
    6. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. PMID: 26655997
    7. PDIA3 and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer. PMID: 26125904
    8. CDDP-resistant non-small lung cancer cells undergo profound remodeling of their endoplasmic reticulum (ER) proteome (>80 proteins identified by proteomics) and exhibit a dramatic overexpression of two protein disulfide isomerases, PDIA4 and PDIA6. PMID: 24464223
    9. Txnip is located in the endoplasmic reticulum and interacts with endogenous PDIA6. Txnip increases PDI activity. PMID: 24843047
    10. levels of expression of ERp5 and GRP78 correlated with the level of expression of membrane-bound MICA in chronic lymphocytic leukemia patients. PMID: 22215138
    11. Data show that the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the ligands for NKG2D (NKG2D-L) from the cell membrane. PMID: 22167753
    12. P5 forms a non-covalent complex with immunoglobulin heavy chain binding protein (BiP) and shows specificity towards BiP client proteins. PMID: 19887585
    13. observed to have peptide-binding ability, and chaperone activity was confirmed with rhodanese and citrate synthase as substrates, but not with D-glyceraldehyde-3-phosphate dehydrogenase, showing substrate specificity with respect to chaperone activity PMID: 12204115
    14. ERP5 regulates the binding of fibrinogen, cell-surface exposure of P-selectin, and coassociation of beta 3 integrin in stimulated platelets. PMID: 15466936
    15. Pharmacological inhibition of thioreductase activity and ERp5 gene silencing revealed that cell-surface ERp5 function is required for MICA shedding PMID: 17495932

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum lumen. Cell membrane. Melanosome.
  • 蛋白家族:
    Protein disulfide isomerase family
  • 組織特異性:
    Expressed in platelets (at protein level).
  • 數據庫鏈接:

    HGNC: 30168

    OMIM: 611099

    KEGG: hsa:10130

    STRING: 9606.ENSP00000272227

    UniGene: Hs.212102



主站蜘蛛池模板: 99久久国产露脸国语对白| 国产精品女丝袜白丝袜| 亚洲色欲综合一区二区三区| 欧美丰满熟妇xxxx| 日韩精品无码免费一区二区三区 | 22222se男人的天堂| 99久久精品免费看国产一区二区三区 | 亚洲日本va中文字幕久久| 亚洲精品日韩一区二区电影| 久久香蕉国产线看观看手机| 人妻aⅴ中文字幕无码| 亚洲欧洲中文日韩久久av乱码| 女的被弄到高潮娇喘喷水视频| 欧美性猛交xxx嘿人猛交| 国产a v高清一区二区三区| 国产三级在线观看完整版| 少妇被黑人到高潮喷出白浆| 人妻一区二区三区高清av专区| 无码专区6080yy国产电影| 日本熟妇浓毛| 亚洲日韩av无码一区二区三区人| 国产麻豆精品精东影业av网站 | 亚洲精品久久国产精品| 天天摸天天做天天爽水多| 2018av天堂在线视频精品观看| 麻豆国产成人av在线播放| 人妻三级日本香港三级极97| 好男人在线社区www在线影院| 国产成人精品视频一区二区不卡| 免费无码不卡中文字幕在线| 国产乱子伦一区二区三区视频播放| 伊人久久大香线蕉综合75| 国产成人精品a视频一区| 亚洲日韩小电影在线观看| 狠狠色噜噜狠狠狠狠五月婷 | 99久久精品国产波多野结衣| 伊人情人综合网| 五月色丁香婷婷网蜜臀av| 少妇人妻无码专区毛片| 国产亚洲精品自在久久| 欧美不卡一卡二卡三卡|