在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDIA3 Antibody

  • 中文名稱:
    PDIA3兔多克隆抗體
  • 貨號(hào):
    CSB-PA06284A0Rb
  • 規(guī)格:
    ¥440
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDIA3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    58 kDa glucose regulated protein antibody; 58 kDa glucose-regulated protein antibody; 58 kDa microsomal protein antibody; Disulfide isomerase ER 60 antibody; Disulfide isomerase ER-60 antibody; Endoplasmic reticulum resident protein 57 antibody; Endoplasmic reticulum resident protein 60 antibody; ER p57 antibody; ER protein 57 antibody; ER protein 60 antibody; ERp 57 antibody; ERp57 antibody; ERp60 antibody; ERp61 antibody; Glucose Regulated Protein 58 Kd antibody; GRP 57 antibody; GRP 58 antibody; GRP57 antibody; HsT17083 antibody; p58 antibody; PDIA 3 antibody; PDIA3 antibody; PDIA3_HUMAN antibody; Phospholipase C alpha antibody; PI PLC antibody; Protein disulfide isomerase A3 antibody; Protein disulfide isomerase family A member 3 antibody; Protein disulfide-isomerase A3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Protein disulfide-isomerase A3 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,PDIA3 Antibody (CSB-PA06284A0Rb),的標(biāo)記方式是Non-conjugated。對(duì)于PDIA3 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA06284B0Rb PDIA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA06284C0Rb PDIA3 Antibody, FITC conjugated
    Biotin CSB-PA06284D0Rb PDIA3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. Data suggest that disulfide bond switch in allosteric activation/inactivation of TGM2 is example of post-translational redox regulation that is reversibly and allosterically modulated by two proteins (ERp57 and TRX). (TGM2 = transglutaminase 2; ERp57 = endoplasmic reticulum resident protein 57; TRX = thioredoxin-1) PMID: 29305423
    2. Study demonstrated that the expression of PDIA3 is frequently upregulated at the mRNA and protein levels in diffuse gliomas. Its high expression was significantly correlated with high Ki-67, more TP53 mutations and poor survival outcome. These findings imply that high expression of PDIA3 plays an important role in diffuse glioma progression. PMID: 29207176
    3. summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various diseases. PMID: 28723413
    4. ERp57 is involved in sperm capacitation and spermatozoa-zona pellucida binding. PMID: 28175305
    5. Thiol isomerase ERp57 is mobilized to the surface of activated platelets via a process that requires actin polymerization. PMID: 27079884
    6. Findings suggested that miR-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR and PDIA3 expression. PMID: 27363653
    7. Our study found increased expression of ERp57 in chronic hepatitis B -hepatocellular carcinoma (HBV-HCC) genesis. Such altered expression could be related to HBV infection and high ERp57 expression may lead to poor prognosis of HBV-HCC patients. PMID: 28373975
    8. The interaction of different flavonoids with PDIA3 was investigated by quenching fluorescence analysis and the effects on protein activity were evaluated. PMID: 28044092
    9. Upregulation of PDIA3 promotes ovarian cancer cell proliferation and migration. PMID: 27492604
    10. Data show that knockdown of endoplasmic reticulum resident protein 57 (ERP57) expression resulted in increase in shikonin induced apoptosis, and suggest that ERP57 might be a therapeutic option for the treatment of acute myeloid leukemia. PMID: 27415599
    11. Amyotrophic lateral sclerosis-linked PDIA3 mutations disrupt motor neuron connectivity. PMID: 26869642
    12. These data indicate that the presence of autoantibodies to PDIA3 favors the development of an efficient and specific T-cell response against PDIA3 in colorectal cancer patients. PMID: 26772958
    13. ERp57 levels are increased in the airway epithelium of asthmatic patients and in mice with allergic airways disease. PMID: 26435004
    14. LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer PMID: 26771192
    15. it is possible that the vimentin and PDIA3 could be the candidate biomarkers specific to Achyranthes saponin therapy for rheumatoid arthritis in synovial membrane. PMID: 26724776
    16. ERp57 specifically contributes to peripheral nerve regeneration, whereas its activity is dispensable for the survival of a specific neuronal population of the central nervous system. PMID: 26361352
    17. Data suggest that regulation of PDIA3 (protein disulfide isomerase associated 3 protein) expression by microRNA-330-5p is important in maintaining hair cycle through regulation of proliferation and migration capability of keratinocytes. PMID: 26402295
    18. miR148a inhibits the proliferation and promotes paclitaxelinduced apoptosis of ovarian cancer cells, and this may be partly attributed to direct targeting of PDIA3. PMID: 26004124
    19. results suggested that ER chaperone PDIA3 plays a pivotal role in FFA-induced hepatocyte steatosis and apoptosis. PMID: 26214517
    20. The sPLA2-hPDI model constitutes a valuable tool to facilitate further insights into this process and into the (patho)physiology of sPLA2s in relation to their action intracellularly. PMID: 25763817
    21. Its cross-reaction to GFAP antibodies seems to lead to a changed signaling in the cells triggering the protective effects. PMID: 25837926
    22. PDIA3 and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer. PMID: 26125904
    23. study identifies ERp57 as a new modulator of PrP levels and may help with understanding the consequences of ERp57 up-regulation observed in human disease PMID: 26170458
    24. Reported increased expression of ALDH3A1, PDIA3, and PRDX2 in pterygia using a proteomic approach. These proteins are presumed to have a protective role against oxidative stress-induced apoptosis. PMID: 25221425
    25. Suggest that ERp57-STAT3 regulation functions in radioresistance of laryngeal cancer. PMID: 25605256
    26. Increased expression of PDIA3 is associated with tumor progression and the clinical behavior of gallbladder carcinoma. PMID: 23782473
    27. Results demonstrated that Grp58 appears to regulate WNT signaling by targeting beta-catenin to augment cancer invasion. PMID: 25081282
    28. Increased expression of the AGR2 and ERp57 is associated with cancer. [review] PMID: 24490732
    29. ERp57 can regulate the expression of the mitochondrial calcium uniporter (MCU) and modulate mitochondrial calcium uptake PMID: 24815697
    30. Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer. PMID: 23957851
    31. ERP57 was excreted in the early stages of chronic kidney disease, and its level in urine correlated with the degree of renal fibrosis, suggesting that the secretion of ERP57 represents one of the first signs of renal fibrosis onset and progression. PMID: 23781031
    32. Tg "adduct B" was identified as primarily engaging the endoplasmic reticulum oxidoreductases ERp57 and protein disulfide isomerase PMID: 24599957
    33. Low PDIA3 expression is associated with chemoresistant colon tumors. PMID: 23255428
    34. ERp57 appears as a multifunctional chaperone that can regulate diverse biological processes to maintain the homeostasis of breast cancer cells and promote the development of bone metastasis. PMID: 23625662
    35. ERp57 positively regulates H(+),K(+)-ATPase activity apart from its chaperoning function. PMID: 24188822
    36. Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation. PMID: 24030382
    37. We postulate that apoB cleavage by ER-60 within the ER lumen could facilitate proteasomal degradation of the C-terminus of translocationally-arrested apoB. PMID: 23827315
    38. Nuclear ERp57 interacts in vivo with DNA fragments in melanoma cells and is potentially involved in the transcriptional regulation of its target genes. PMID: 23587917
    39. ERp57 regulates RalA signalling by acting as a redox-sensitive guanine-nucleotide dissociation inhibitor. PMID: 23226417
    40. Data indicate that the peptide-loading complex (PLC) consists maximally of 2x tapasin-ERp57/MHC I per TAP complex, but one tapasin-ERp57/MHC I in the PLC is essential and sufficient for antigen processing. PMID: 22923333
    41. Downregulation of ER60 protease is associated with inhibition of cell proliferation in breast cancer cells in vitro. PMID: 22266712
    42. PDIA3 may play in the progression of heart failure. PMID: 22503978
    43. the vitamin D receptor (VDR) and ERp57 are critical components for actions of 1,25 dihydroxy vitamin D 3 against DNA damage, but the VDR does not require normal DNA binding or classical ligand binding to mediate photoprotection. PMID: 22322599
    44. kinetic, extent and stability of the ERp57-CRT complex, using the surface plasmon resonance spectroscopy PMID: 21996511
    45. ERp57 has roles in multiple components of platelet function and arterial thrombus formation. PMID: 22168334
    46. These results suggest that increased level of hnRNP-H and PDIA3 expression in Dengue virus infected THP1 cells assist in the viral replication by suppressing the TNF-alpha production. PMID: 22207023
    47. PDIA3 and GRP78 are IL11 targets in invasive trophoblasts PMID: 21840908
    48. Grp58 is highly expressed in patients with serious cervical stromal penetration, and further supports the theory that Grp58 is critical for cervical AD progression. PMID: 21917082
    49. ERp57 participates in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair. (Review) PMID: 21837552
    50. Immunostaining for both ERp57-GFP and p65 after TNF-alpha treatment indicated that nuclear translocation of these two proteins occurs independently PMID: 21598303

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome.
  • 蛋白家族:
    Protein disulfide isomerase family
  • 組織特異性:
    Detected in the flagellum and head region of spermatozoa (at protein level). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4606

    OMIM: 602046

    KEGG: hsa:2923

    STRING: 9606.ENSP00000300289

    UniGene: Hs.591095



主站蜘蛛池模板: 久久综合色之久久综合| 一边吃奶一边做动态图| 亚洲人成电影网站色www两男一女| 无套内射视频囯产| 亚洲一区日韩高清中文字幕亚洲| 777米奇色狠狠俺去啦| 亚洲精品成a人在线观看| 黑人粗长大战亚洲女| 久久久噜噜噜久久熟女aa片| 国产成人精品一区二区秒播| 亚洲最大av资源站无码av网址| 国产网红主播无码精品| 越猛烈欧美xx00动态图| 中文无码日韩欧av影视| 国产乱人伦偷精品视频不卡| 久久久久无码中| 最新国产久免费视频在线观看| 四虎成人精品永久在线视频| 精品久久久久久久久久久aⅴ| 97无码免费人妻超级碰碰夜夜| 国产精品成人观看视频| 日韩欧群交p片内射中文| 国产成人精品无码片区在线观看| 亚洲综合最新无码专区| 国产国产裸模裸模私拍视频| 欧美综合自拍亚洲综合图| 天堂网在线最新版www中文网| av区无码字幕中文色| 99精品人妻少妇一区二区| 99久久人妻精品免费二区| 成人无码a片一区二区三区免| 男人的天堂2018无码| 欧美乱人伦人妻中文字幕| 国产女人精品视频国产灰线| 无码专区亚洲制服丝袜| 久久国产色av| 无码人妻丰满熟妇精品区| 国产jjizz女人多水| 欧美性受xxxx狂喷水| 亚洲午夜精品一区二区| 国产孩cao大人xxxx|