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PDE8A Antibody, FITC conjugated

  • 中文名稱:
    PDE8A兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA525315LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDE8A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDE8A
  • 別名:
    5''-cyclic phosphodiesterase 8A antibody; cAMP specific cyclic nucleotide phosphodiesterase 8A antibody; FLJ16150 antibody; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody; High affinity cAMP-specific and IBMX-insensitive 3'' antibody; HsT19550 antibody; PDE 8A antibody; PDE8A antibody; PDE8A_HUMAN antibody; Phosphodiesterase 8A antibody; Phosphodiesterase8A antibody; Weakly similar to 3'5' cyclic nucleotide phosphodiesterase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A protein (596-829AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.
  • 基因功能參考文獻(xiàn):
    1. SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq PMID: 27560698
    2. PDE8A supports HIV-1 replication in macrophages PMID: 25295610
    3. a novel and critical role for phosphodiesterases in moderating local concentrations of cAMP in microdomains and signal resetting PMID: 25229150
    4. PDE8A can bind tightly to Raf-1, regulate Raf-1 phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 signaling, retarding subsequent ERK phosphorylation and activation. PMID: 23509299
    5. PDE8 activity can be modulated by a kinase PMID: 22673573
    6. Polymorphism in PDE8A affects HIV-1 replication in primary macrophages. PMID: 21920574
    7. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. PMID: 12681444
    8. in vitro and in vivo experiments demonstrated that the association with IkappaB greatly enhanced the enzyme activity of PDE8A1 PMID: 15596729
    9. kinetic properties of the highly active PDE8A1 catalytic domain prepared from refolding and its crystal structures in the unliganded and 3-isobutyl-1-methylxanthine (IBMX) bound forms at 1.9 and 2.1 A resolutions PMID: 18983167
    10. The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las major determinant of androgen levels in women. PMID: 19482904

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  • 蛋白家族:
    Cyclic nucleotide phosphodiesterase family, PDE8 subfamily
  • 組織特異性:
    Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8793

    OMIM: 602972

    KEGG: hsa:5151

    STRING: 9606.ENSP00000311453

    UniGene: Hs.9333



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