在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDE6C Antibody, HRP conjugated

  • 中文名稱:
    PDE6C兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA23139B0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDE6C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDE6C
  • 別名:
    5''-cyclic phosphodiesterase subunit alpha'' antibody; cGMP phosphodiesterase 6C antibody; COD4 antibody; Cone cGMP specific 3' 5' cyclic phosphodiesterase subunit alpha' antibody; Cone cGMP-specific 3'' antibody; PDE 6C antibody; PDE6 alpha prime antibody; PDE6 alpha' antibody; PDE6C antibody; PDE6C_HUMAN antibody; PDEA2 antibody; Phosphodiesterase 6C cGMP specific cone alpha prime antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' protein (285-451AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.
  • 基因功能參考文獻(xiàn):
    1. This study reveals two general mechanisms of missense PDE6C mutations underlying retinal diseases: (a) inability of AIPL1 to fold mutant PDE6C proteins leading to complete catalytic inactivity and (b) failure of P gamma regulatory subunit to serve as co-chaperone with AIPL1 in folding of mutant PDE6C. PMID: 28583373
    2. A novel homozygous PDE6C mutation was identified as the cause of ACHM. In addition, we identified an OPN1SW mutation in the sibling with complete achromatopsia. PMID: 25605338
    3. Expression of PDE6 in rod photoreceptors show that the cone PDE6 isoform is responsible for the difference in light adaptation between rods and cones. PMID: 26085644
    4. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R). PMID: 23362848
    5. Missense mutations, nonsense mutations, splice mutations, and small deletions and insertions in the affected genes cause achromatopsia. PMID: 21267001
    6. Eleven different PDE6C mutations were found including two nonsense mutations, three mutations affecting transcript splicing as shown by minigene assays, one 1 bp-insertion and five missense mutations PMID: 21127010
    7. Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders. PMID: 19615668
    8. analysis of human cone phosphodiesterase-6 ectopically expressed in Xenopus laevis rods PMID: 19801642
    9. the identification of mutations in the PDE6C gene encoding the catalytic subunit of the cone photoreceptor phosphodiesterase as a cause of autosomal recessive achromatopsia was reported. PMID: 19887631

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Cone dystrophy 4 (COD4); Achromatopsia 5 (ACHM5)
  • 亞細(xì)胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Cyclic nucleotide phosphodiesterase family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8787

    OMIM: 600827

    KEGG: hsa:5146

    STRING: 9606.ENSP00000360502

    UniGene: Hs.658121



主站蜘蛛池模板: 成人无码潮喷在线观看| 成人内射国产免费观看| 在线观看国产成人av天堂| 久久中文字幕无码中文字幕有码| 特级a欧美做爰片第一次| 国产裸拍裸体视频在线观看| 国产一区二区女内射| 五月丁香综合缴情六月小说| 无码综合天天久久综合网色吧影院 | 狠狠色丁香久久婷婷综合蜜芽五月 | 无遮挡边吃摸边吃奶边做| 精品久久久久久人妻无码中文字幕| 日本在线高清不卡免费播放| 一区二三区国产好的精华液o9| 国产精品无码午夜免费影院| 粗大猛烈进出高潮视频免费看| 亚欧免费无码aⅴ在线观看蜜桃| 亚洲乱亚洲乱妇无码麻豆| 无码人妻精品一区二区三区蜜桃| 成人免费xxxxx在线观看| 特殊重囗味sm在线观看无码| 国产av国片精品有毛| 国产在线无码一区二区三区视频| 亚洲人午夜射精精品日韩| 久久精品成人欧美大片| 4hu亚洲人成人无码网www电影首页| 欧美老熟妇videos极品另类| 野花社区在线www日本| 四虎永久在线精品8848a| 欧美极品少妇无套实战| 日韩免费无码一区二区视频| 无码免费无线观看在线视| 日日av拍夜夜添久久免费| 天码av无码一区二区三区四区| 亚洲人成网亚洲欧洲无码久久| 国产裸体歌舞一区二区| 国产精品爽爽久久久久久| 一边捏奶头一边啪高潮视频| 亚洲成av 人片在线观看无码| 国产卡一卡二卡三| 国产探花在线精品一区二区|