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PCP4 Antibody

  • 中文名稱:
    PCP4兔多克隆抗體
  • 貨號:
    CSB-PA905587
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA905587(PCP4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PCP4
  • 別名:
    Brain specific antigen PCP 4 antibody; Brain specific polypeptide PEP 19 antibody; Brain specific polypeptide PEP19 antibody; Brain-specific antigen PCP-4 antibody; Brain-specific polypeptide PEP-19 antibody; OTTHUMP00000109191 antibody; Pcp4 antibody; PCP4_HUMAN antibody; PEP19 antibody; Purkinje cell protein 4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human PCP4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways.
  • 基因功能參考文獻:
    1. PCP4 promoter was one of the most hypomethylated in aldosterone-producing adenoma and PCP4 transcription may be associated with demethylation as well as with CEBPA in APAs. PMID: 29294065
    2. PCP4/PEP19 has a role in promoting migration, invasion and adhesion in human breast cancer cells PMID: 27384474
    3. Data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown. PMID: 25153723
    4. PCP4 protein is highly expressed in the olfactory bulb and caudate putamen and PCP4 expressing cells in the brain are of neuronal origin. PMID: 24954028
    5. PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells. PMID: 24403568
    6. This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum. PMID: 24291518
    7. The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release. PMID: 23204517
    8. Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation. PMID: 21491429
    9. The PCP4 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    10. PEP-19 has the potential to alter the Ca2+-binding dynamics of free CaM and CaM that is bound to other target proteins PMID: 14551202

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  • 蛋白家族:
    PCP4 family
  • 數據庫鏈接:

    HGNC: 8742

    OMIM: 601629

    KEGG: hsa:5121

    STRING: 9606.ENSP00000329403

    UniGene: Hs.80296



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