在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PCMT1 Antibody, HRP conjugated

  • 中文名稱:
    PCMT1兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA017618LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PCMT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PCMT1
  • 別名:
    PCMT1 antibody; Protein-L-isoaspartate(D-aspartate) O-methyltransferase antibody; PIMT antibody; EC 2.1.1.77 antibody; L-isoaspartyl protein carboxyl methyltransferase antibody; Protein L-isoaspartyl/D-aspartyl methyltransferase antibody; Protein-beta-aspartate methyltransferase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Protein-L-isoaspartate(D-aspartate) O-methyltransferase protein (117-228AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
  • 基因功能參考文獻(xiàn):
    1. decrease of PCMT1 significantly increased the proportion of D-Asp residues in PHB1 and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system PMID: 27327778
    2. PIMT heterozygosity for R36C, G175R, R17H, or R17S would be detrimental to successful aging, whereas homozygosity (should it ever occur) would produce devastating neuropathology PMID: 28100787
    3. Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma. PMID: 26997432
    4. The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death PMID: 25800307
    5. ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis. PMID: 24358311
    6. Overexpression of PCMT1 attentuates Mst1 kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes. PMID: 23647599
    7. Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp, and is able to restore Arabidopsis PRH75's complex biochemical activity provided isoAsp formation has not led to conformational alterations. PMID: 23903319
    8. Data show six differentially expressed proteins were identified as HSP70, PPIA and alpha-Enolase (up-regulated) S100-A9, PIMT and beta-5 tubulin (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis. PMID: 21839816
    9. The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang. PMID: 22647835
    10. Study provides new insight into the molecular mechanisms by which PIMT suppresses the p53 activity through carboxyl methylation, and suggests a therapeutic target for cancers. PMID: 22735455
    11. PIMT may act as a co-activator in ERalpha-mediated transcription of TFF1 through its recruitment to the promoter via interacting with ERalpha. PMID: 22382029
    12. Control of PCMT1 expression by microRNA 15a/16-1 may thus represent a late checkpoint in apoptosis regulation PMID: 22033921
    13. A tight cross-regulation exists between ERK and PIMT in regards to their activation and expression during the epithelial mesenchymal transition. PMID: 21841813
    14. study demonstrates a novel role for PIMT as a negative regulator of Abeta peptide formation and a potential protective factor in the pathogenesis of Alzheimer disease PMID: 21372823
    15. Protein L-Isoaspartyl Methyltransferase PMID: 11792715
    16. crystal structure complexed with adenosyl homocysteine (AdoHcy) to 1.6-A resolution PMID: 11847284
    17. Our results showed that the Ile120Val polymorphism of PCMT1 gene is a genetic modifier for the risk of spina bifida. Val/Val genotype was associated with a reduction in risk for spina bifida. PMID: 16256389
    18. A potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination. PMID: 17167531
    19. These results suggest that PIMT repair of abnormal proteins is necessary to maintain normal MAPK signaling. PMID: 18381200
    20. Four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF). PMID: 18582870

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    Methyltransferase superfamily, L-isoaspartyl/D-aspartyl protein methyltransferase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8728

    OMIM: 176851

    KEGG: hsa:5110

    STRING: 9606.ENSP00000356348

    UniGene: Hs.279257



主站蜘蛛池模板: 日韩一区二区a片免费观看| 亚洲精品亚洲人成人网| 99久久精品日本一区二区免费 | 久久久久国产精品人妻aⅴ牛牛| 男女同房做爰爽免费| 国产av区男人的天堂| 裸体女人高潮毛片| 性色香蕉av久久久天天网| 久久无码专区国产精品| 欧美人与动性xxxxx杂性| 一二三四在线观看免费视频| 在线人人车操人人看视频| 蜜臀精品国产高清在线观看| 亚洲欧美在线观看品| 精品无码久久久久久久动漫| 国产精品成人一区无码| 亚洲性无码av在线欣赏网| 久久国产成人免费网站| 天天摸夜夜添狠狠添高潮出水| 国产好大好硬好爽免费视频| 天天做天天爱夜夜爽毛片毛片| 欧美激情一区二区| 熟妇人妻午夜寂寞影院| 中文字幕av无码不卡免费| 欧美日韩无砖专区一中文字| 亚洲蜜桃v妇女| 久久精品国产99国产精品亚洲| 色偷偷av一区二区三区| 中文字幕丝袜精品久久| 亚洲色欲色欲www在线看| 后入内射无码人妻一区| 99re热视频这里只精品| 亚洲精品一区二区不卡| 中文字幕亚洲码在线| 亚洲色成人网一二三区| 强辱丰满人妻hd中文字幕| 国产色青青视频在线观看撒| 国产日韩综合一区在线观看| 50路60路老熟妇啪啪| 精品麻豆国产色欲色欲色欲www| 2021年精品国产福利在线|