在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PCK2 Antibody, HRP conjugated

  • 中文名稱:
    PCK2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA619092LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PCK2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    EC 4.1.1.32 antibody; GTP mitochondrial precursor antibody; HGNC:8725 antibody; mitochondrial antibody; Mitochondrial phosphoenolpyruvate carboxykinase 2 antibody; OTTHUMP00000164700 antibody; PCK2 antibody; PCKGM_HUMAN antibody; PE antibody; PEP carboxykinase antibody; PEPCK antibody; PEPCK deficiency mitochondrial antibody; PEPCK M antibody; PEPCK-M antibody; PEPCK2 antibody; Phosphoenolpyruvate carboxykinase [GTP] antibody; Phosphoenolpyruvate carboxykinase 2 (mitochondrial) antibody; Phosphoenolpyruvate carboxykinase 2 mitochondrial antibody; Phosphoenolpyruvate carboxylase antibody; Phosphopyruvate carboxylase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphoenolpyruvate carboxykinase [GTP], mitochondrial protein (101-400AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
  • 基因功能參考文獻:
    1. Our study indicates that the T allele of the rs4982856 single-nucleotide polymorphisms in the PCK2 gene may be a risk factor for glucose intolerance after kidney transplantation PMID: 29731064
    2. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma PMID: 28166201
    3. ApoA-IV colocalizes with NR4A1, which suppresses G6Pase and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose. PMID: 26556724
    4. Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine metabolism, increases anabolic metabolism and promotes mTORC1 activity. PMID: 26481663
    5. Mitochondrial PCK2 regulates metabolic adaptation and enables glucose-independent tumor growth in various neoplasms. PMID: 26474064
    6. When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B cells. PMID: 26036577
    7. PEPCK activity was elevated threefold in lung cancer samples over normal lungs and its activation mediates an adaptive response to glucose depletion in lung cancer. PMID: 24632615
    8. Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines. PMID: 24973213
    9. Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells. PMID: 24602180
    10. expression of HCV nonstructural component NS5A in Huh7 or primary hepatocytes stimulated PEPCK gene expression and glucose output in HepG2 cells. PMID: 22955269
    11. results reveal a novel link between glucose metabolism and the DNA damage signaling pathway and suggest a possible role for PEPCK and G6P in the DNA damage response PMID: 21733854
    12. Endoplasmic reticulum stress triggers suppression of AMPK while increasing C/EBPbeta and pCREB expression which activates PEPCK gene transcription. PMID: 20797423
    13. Results suggest that pepck2 gene expression is regulated by its 5' flanking region up to 822 bp, and 317 bp upstream of transcriptional start point. PMID: 15315819
    14. Wild-type AREBP, but not Ser(470) to Ala(470) substituted non-phosphorylating mutant, represses gene expression of the phosphoenolpyruvate carboxykinase (PEPCK), a key enzyme of gluconeogenesis. PMID: 17097062
    15. skeletal muscle PEPCK has a role in determining physical activity levels PMID: 19521512
    16. Increased transcriptional expression of PEPCK1 and G6Pc does not account for increased gluconeogenesis and fasting hyperglycemia in patients with type 2 diabetes mellitus. PMID: 19587243

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Phosphoenolpyruvate carboxykinase [GTP] family
  • 數據庫鏈接:

    HGNC: 8725

    OMIM: 261650

    KEGG: hsa:5106

    STRING: 9606.ENSP00000216780

    UniGene: Hs.75812



主站蜘蛛池模板: 久久人妻精品白浆国产| 色婷婷五月综合久久| 永久免费无码国产| 国产av国片精品有毛| 成人婷婷网色偷偷亚洲男人的天堂| 亚洲 小说区 图片区 都市| 蜜桃成人无码区免费视频网站| 久久久久国产精品人妻aⅴ天堂| 日产精品一卡2卡三卡4乱码| 亚洲另类激情综合偷自拍图| 国产精品美女被遭强扒开双腿| 日本丰满妇人成熟免费中文字幕 | 国产精品久久无码不卡| 国内精品自线在拍2020不卡| 伊人久久大香线蕉亚洲五月天| 亚欧美无遮挡hd高清在线视频| 色综合网天天综合色中文| 国内精品2020情侣视频| 中文字幕人妻无码系列第三区| 无码国产乱人伦偷精品视频| 菠萝菠萝蜜午夜视频在线播放观看| 日韩 亚洲 欧美 国产 精品| 国产成人无码www免费视频播放| 隔壁老王国产在线精品| 国产美女嘘嘘嘘嘘嘘| 丝袜熟女国偷自产中文字幕亚洲| 性做久久久久久久免费看| 伊人色综合久久天天五月婷| 华人在线亚洲欧美精品| 欧美不卡视频一区发布| 国产成人精品三级麻豆| 国产成人免费ā片在线观看老同学| 国产天美传媒性色av出轨 | 2020年无码国产精品高清免费| 日韩精品久久久久久免费| 亚洲欧美丝袜精品久久| 国内熟妇人妻色在线视频| 伊人99综合精品视频| 日韩va中文字幕无码电影| 成 人 黄 色 大片| 国产三级在线观看播放视频|