在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PCGF1 Antibody, Biotin conjugated

  • 中文名稱:
    PCGF1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA863114LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PCGF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    PCGF1 antibody; NSPC1 antibody; RNF68 antibody; Polycomb group RING finger protein 1 antibody; Nervous system Polycomb-1 antibody; NSPc1 antibody; RING finger protein 68 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Polycomb group RING finger protein 1 protein (113-187AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.
  • 基因功能參考文獻:
    1. The results of the present study demonstrated that miR320a inhibition decreased insulininduced KGN cell proliferation and apoptosis by targeting PCGF1. PMID: 28849208
    2. these results demonstrate that NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 and may provide novel targets for glioma treatment in the future. PMID: 28394339
    3. knockdown of PCGF1 results in reduced expression of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels. Thus, PCGF1 represents a physical and functional link between Polycomb function and pluripotency PMID: 26687479
    4. polycomb has a role in stem cell fate and development of cancer (review) PMID: 15315754
  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 17615

    OMIM: 610231

    KEGG: hsa:84759

    STRING: 9606.ENSP00000233630

    UniGene: Hs.316750



主站蜘蛛池模板: 欧美国产日韩亚洲中文| 无尺码精品产品网站| 最新国产在线拍揄自揄视频| 欧美颜射内射中出口爆在线| 风流老熟女一区二区三区| 天天狠天天透天干天干| 综合无码精品人妻一区二区三区| 日本xxxx18野外无毒不卡| 丰满熟女人妻中文字幕免费| 内射无码专区久久亚洲| 国产极品精品自在线| 18勿入网站免费永久| 国产精品人成视频免费播放| 国产欠欠欠18一区二区| 熟女俱乐部五十路六十路av| 无码国模产在线观看免费| 精品美女国产互换人妻| 欧美人与性动交ccoo| 国产精品久久久久永久免费看| 成人亚洲精品久久99狠狠| a∨在线视频播放| 亚洲欧美日韩在线一区| 使劲快高潮了国语对白在线| 三级久久试看3分钟| 国产精品欧美久久久久无广告 | 激情欧美日韩一区二区| 麻豆精产一二三产区| 亚洲精品高清国产一久久| 国产极品粉嫩泬免费观看| 一本大道久久东京热无码av| 欧洲人免费视频网站在线| 狠狠色丁香久久综合| www国产无套内射com| 欧美深性狂猛ⅹxxx深喉| 青草青在线视频在线观看| 亚洲天天做日日做天天欢毛片| 国产成人久久婷婷精品流白浆 | 国产精品水嫩水嫩| 凹凸国产熟女精品视频| 国产午夜亚洲精品理论片不卡| 亚洲人成网7777777国产|