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PCBD1 Antibody

  • 中文名稱:
    PCBD1兔多克隆抗體
  • 貨號:
    CSB-PA017514GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PCBD1
  • 別名:
    4 alpha hydroxy tetrahydropterin dehydratase antibody; 4-alpha-hydroxy-tetrahydropterin dehydratase antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; DCoH antibody; Dimerization cofactor of hepatic nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1-alpha antibody; Dimerization cofactor of HNF1 antibody; Dimerizing cofactor for HNF1 antibody; PCBD 1 antibody; PCBD antibody; PCBD1 antibody; PCD antibody; Phenylalanine hydroxylase stimulating protein antibody; Phenylalanine hydroxylase-stimulating protein antibody; PHS antibody; PHS_HUMAN antibody; Pterin 4 alpha carbinolamine dehydratase antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Pterin carbinolamine dehydratase antibody; Pterin-4-alpha-carbinolamine dehydratase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PCBD1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.
  • 基因功能參考文獻:
    1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes. PMID: 24848070
    2. Coactivator of the HNFB1 (HNF1 homeobox B)-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule PMID: 24204001
    3. Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha. PMID: 9092652
    4. variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function PMID: 11668623
    5. Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target. PMID: 12565907
    6. Albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium. PMID: 15740590
    7. Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH PMID: 16423549

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  • 相關疾病:
    Hyperphenylalaninemia, BH4-deficient, D (HPABH4D)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Pterin-4-alpha-carbinolamine dehydratase family
  • 數據庫鏈接:

    HGNC: 8646

    OMIM: 126090

    KEGG: hsa:5092

    STRING: 9606.ENSP00000299299

    UniGene: Hs.3192



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