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  4. PBXIP1 Antibody, FITC conjugated

PBXIP1 Antibody, FITC conjugated

  • 中文名稱：
    PBXIP1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA856896HC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PBXIP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PBXIP1
  • 別名：
    PBXIP1 antibody; HPIPPre-B-cell leukemia transcription factor-interacting protein 1 antibody; Hematopoietic PBX-interacting protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Pre-B-cell leukemia transcription factor-interacting protein 1 protein (361-600AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
  • 基因功能參考文獻：
    1. HPIP promotes gastric cancer cell proliferation through positive regulation of cap-dependent translation. PMID: 27748944
    2. Knockdown of HPIP suppressed TGF-beta1-induced EMT. PMID: 27178820
    3. our findings identified HPIP plays an important role in the progression and EMT of spinal glioblastoma, by which cell growth is improved. Thus, HPIP gene or protein could act as a useful target in the clinical practice. PMID: 26590606
    4. Copy number variations in PBXIP1 gene is associated with lung adenocarcinoma. PMID: 26497366
    5. HPIP may play critical role in oral carcinogenesis and is potential target for anticancer therapy, with particular emphasis on its involvement in differentiation and migration/metastasis. PMID: 25060351
    6. PBXIP1 is a novel protein overexpressed in astrocytoma and ependymoma, involved in tumor cell proliferation and migration PMID: 24470547
    7. These data highlight the important role of HPIP in liver cancer cell growth and suggest that HPIP may be a good target for liver cancer therapy. PMID: 24038948
    8. HPIP is a target of GATA1 and CTCF in erythroid cells and plays an important role in erythroid differentiation by modulating the PI3K/AKT pathway PMID: 22187427

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
  • 組織特異性：
    Expressed in early hematopoietic precursors.
  • 數據庫鏈接：

    HGNC: 21199

    KEGG: hsa:57326

    STRING: 9606.ENSP00000357448

    UniGene: Hs.505806



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