在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PBX1 Antibody, HRP conjugated

  • 中文名稱:
    PBX1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA017505LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PBX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PBX1
  • 別名:
    DKFZp686B09108 antibody; Homeo box protein PBX1 antibody; Homeo box protein PRL antibody; Homeobox protein PBX 1 antibody; Homeobox protein PBX1 antibody; Homeobox protein PRL antibody; MGC126627 antibody; PBX 1 antibody; Pbx1 antibody; PBX1_HUMAN antibody; Pre B cell leukemia homeobox 1 antibody; Pre B cell leukemia transcription factor 1 antibody; Pre-B-cell leukemia transcription factor 1 antibody; PRL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Pre-B-cell leukemia transcription factor 1 protein (315-430AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8. Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein. Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4. Acts as a transcriptional activator of PF4 in complex with MEIS1. Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence. In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development. Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression.; As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.
  • 基因功能參考文獻:
    1. PBX1 plays an oncogenic role in clear cell renal carcinoma via JAK2/STAT3 pathway PMID: 29678569
    2. B-cell acute lymphoblastic leukemia patients with positive E2A-PBX1 fusion expression after transplant will have a poor prognosis. PMID: 29705861
    3. Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation. PMID: 28034988
    4. The sequence variants in our cases included missense substitutions adjacent to the PBX1 homeodomain (p.Arg184Pro, p.Met224Lys, and p.Arg227Pro) or within the homeodomain (p.Arg234Pro, and p.Arg235Gln), whereas p.Ser262Glnfs*2, and p.Arg288* yielded truncated PBX1 proteins. PMID: 29036646
    5. PBX1 is one of the determinants in the Cx32 promoter targeting site, preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis. PMID: 28839434
    6. A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma PMID: 28514754
    7. PBX1 haploinsufficiency leads to syndromic CAKUT. PMID: 28270404
    8. This is the first time the protein partners of either E2A-PBX1 or HOXA9 oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 might indicate a novel function for HOX proteins independent of their transcriptional activity. PMID: 28707666
    9. involved in monogenic anomalies of kidney and urinary tract PMID: 28566479
    10. these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions. PMID: 28257976
    11. the PBX1 binding motif at its promoter acted to positively regulate STAT3 transcription. PMID: 27590741
    12. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function PMID: 27296664
    13. Notably, PBX1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 levels increases damage by oxidative stress in human midbrain cells. PMID: 27354364
    14. PBX1 overexpression in MCF10A cells up-regulated most LiMe genes. PMID: 28263391
    15. results indicate that E2A-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A fusion genes to develop B-lineage ALL PMID: 27088431
    16. Review of the role of the E2A-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse. PMID: 26509298
    17. This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia. PMID: 26971355
    18. Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha-positive breast cancers. PMID: 26215677
    19. We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 as well as an enrichment of genes involved in immunity and infection pathways in ETV6-RUNX1 subtype PMID: 26237075
    20. This association study successfully identified two susceptibility Single Nucleotide Polymorphisms, (WNT9B and PBX1) associated with Mayer-Rokitansky-Kuster-Hauser syndrome risk, both separately and interactively. PMID: 26075712
    21. PBX1 promotes frontal cortex patterning by repressing genes that promote dorsocaudal fate. PMID: 26671461
    22. Hematopoietic pre-B cell leukemia transcription factor interacting protein enhances gastric cancer cell migration and invasion, and modulates epithelial-mesenchymal transition, which plays a key role in cancer cell migration and invasion. PMID: 26211905
    23. When intensive chemotherapy was used, the TCF3-PBX1 was associated with a favorable outcome in childhood pre-B ALL. PMID: 25551271
    24. Induction of PBX1 expression was associated with 13-cisRA responsiveness in neuroblastoma. PMID: 24947929
    25. In this study, we showed that TCF3-PBX1 positive pediatric BCP-ALL patients treated according to the JACLS ALL02 and CCLSG ALL2004 protocol had favorable outcomes PMID: 24578304
    26. E2A-PBX1 fusion gene caused by t(1;19)(q23;p13) may be a common genetic change in AIS and a survival determinant for female AIS patients at early stage. PMID: 23688269
    27. Data indicate that among 31 thymus development-related genes, PBX1 copy number gain and FOXC1 copy number loss were presented in 43.0% and 39.5% of the tumors, respectively. PMID: 23444221
    28. E2a-pbx1-positive patients are associated with more aggressive acute lymphoblastic leukemia. PMID: 23511488
    29. The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers. PMID: 22567123
    30. PBX1 is a novel pioneer factor defining aggressive ERalpha-positive breast tumors, as it guides ERalpha genomic activity to unique genomic regions promoting a transcriptional program favorable to breast cancer progression. PMID: 22125492
    31. Splice isoform PBX1-d is expressed more frequently in CD4+ T cells from lupus patients than from healthy controls. Its presence correlates with an increased central memory T cell population. PMID: 22180614
    32. vthe importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1 PMID: 21957483
    33. Klf4 recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 target genes. PMID: 21746878
    34. Identified 2 known single nucleotide polymorphisms, which indicates that mutations in the coding sequence of PBX1 are not responsible for Mullerian duct abnormalities in Chinese women. PMID: 21575942
    35. The C-terminal extension of PBX1 folds to form a fourth alpha-helix to a level of 5-10%, even in the absence of binding partners. This suggests that PBX1 transiently preorganizes prior to binding DNA. PMID: 21087615
    36. Data show that binding of DHS with sequences of HNF1, CDX2, and PBX1 in vitro contribute to understanding of the complexity of cell-type-specific CFTR regulatory mechanisms. PMID: 19782160
    37. Data demonstrated that overexpressed PBX1 and MEIS1 increased endogenous SOX3 protein expression in both uninduced and RA-induced NT2/D1 cells. PMID: 19799567
    38. these studies demonstrate that the homeodomain proteins, MEIS1, PBX1B, and PBX2, play an important role in megakaryocytic gene expression PMID: 12609849
    39. PBX1 complexed with HOXA9 and DNA, so that the posterior Hox hexapeptide adopts an altered conformation. PMID: 12923056
    40. E2a-Pbx1 and Bmi-1 are likely to play a role in the pathogenesis of human lymphoid leukemias through downregulation of the INK4A-ARF gene PMID: 14536079
    41. E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells PMID: 15507449
    42. HoxD9 and Pbx1 are inappropriately expressed in most human esophageal squamous cell carcinoma. Understanding the role of Hox genes in esophageal epithelial cell carcinogenesis may not only augment early detection but also offer possiblde treatment. PMID: 15770739
    43. In pancreatic exocrine tissue from obese non-diabetic subjects with increased islet mass, we found that Pbx-1 and Pdx-1 were up-regulated (5.9+/-1.2 and 2.4+/-0.6 versus non-obese). PMID: 15979049
    44. No coding variant was associated with diabetes and no association was found among African American subjects. Three variants in Caucasians were associated with T2DM. Three variants were significant determinants of insulin sensitivity PMID: 16140554
    45. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: E2A/PBX1 and E2A/HLF. PMID: 16215946
    46. Required for pro-angiogenic homeobox Hox DNA binding and transcriptional activity in endothelial cells. PMID: 16328158
    47. Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer. PMID: 16637071
    48. Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
    49. Amino acid substitutions that prevent helix formation prevent both the interaction with KIX domain of cyclic AMP response element-binding protein (CBP) and cell immortalization by E2A-PBX1. PMID: 16914730
    50. Expanded polyhistidine repeats in HOXA1 enhance aggregation and cell death, resulting in impaired neuronal differentiation and cooperative binding with PBX1. PMID: 17131398

    顯示更多

    收起更多

  • 相關疾病:
    Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (CAKUTHED)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    TALE/PBX homeobox family
  • 組織特異性:
    Expressed in the kidney. Expressed in the endothelial cells of the glomeruli and interstitium (at protein level). Expressed in all tissues except in cells of the B and T lineage. Expressed strongly in kidney and brain.
  • 數據庫鏈接:

    HGNC: 8632

    OMIM: 176310

    KEGG: hsa:5087

    STRING: 9606.ENSP00000405890

    UniGene: Hs.557097



主站蜘蛛池模板: 亚洲成av人片在线观看天堂无码| 人妻出轨av中文字幕| 亚洲国产精品无码久久久蜜芽 | 亚洲精品色情aⅴ色戒| 亚洲精品久久久久中文字幕一福利| 色五月丁香六月欧美综合| 国产乱人激情h在线观看| 成人亚洲a片v一区二区三区日本| 免费无码又爽又刺激软件下载| 国产女人乱子对白av片| 99久久久无码国产精品6| 又色又爽又高潮免费视频国产 | 忘忧草社区中文字幕www| 欧美一性一乱一交一免费视频 | 国产精品人人做人人爽人人添| 精品 日韩 国产 欧美 视频| 亚洲国产成人久久综合电影| 天堂√在线中文最新版| 亚洲熟熟妇xxxx| 成人免费无码视频在线网站| 欧美综合精品久久久久成人影院| 无遮无挡三级动态图| 国产白丝无码免费视频| 国产欧美在线亚洲一区| 亚洲a∨无码男人的天堂| 麻花豆传媒剧国产免费mv入口| 久久99亚洲含羞草影院| 国产av午夜精品一区二区三| 亚洲中文字幕无码中文字在线| _97夜夜澡人人爽人人喊_欧美| 男女扒开双腿猛进入免费看污| 色欲综合一区二区三区| 18禁女裸乳扒开免费视频| 国产成人午夜福利在线小电影| 97人摸人人澡人人人超碰| 亚洲a∨国产av综合av下载| 国产成人综合久久精品推下载| a欧美爰片久久毛片a片| 久久人人爽人人爽人人片av不| 狠狠五月深爱婷婷网| 国产成人av无码永久免费一线天|