在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PARP2 Antibody, FITC conjugated

  • 中文名稱:
    PARP2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA866224LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PARP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ADP ribosyltransferase like 2 antibody; ADP-ribosyltransferase diphtheria toxin-like 2 antibody; ADPRT 2 antibody; ADPRT-2 antibody; ADPRT2 antibody; ADPRTL 2 antibody; ADPRTL 3 antibody; ADPRTL2 antibody; ADPRTL3 antibody; ARTD2 antibody; hPARP 2 antibody; hPARP-2 antibody; hPARP2 antibody; NAD(+) ADP ribosyltransferase 2 antibody; NAD(+) ADP-ribosyltransferase 2 antibody; pADPRT 2 antibody; pADPRT-2 antibody; pADPRT2 antibody; PARP 2 antibody; PARP-2 antibody; PARP2 antibody; PARP2_HUMAN antibody; Poly (ADP ribose) polymerase family member 2 antibody; Poly (ADP ribosyl) transferase like 2 antibody; poly (ADP-ribose) polymerase 2 antibody; Poly [ADP ribose] synthetase 2 antibody; Poly [ADP-ribose] polymerase 2 antibody; Poly(ADP ribose) synthetase antibody; Poly[ADP-ribose] synthase 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Poly [ADP-ribose] polymerase 2 protein (14-149AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site. PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex.
  • 基因功能參考文獻:
    1. PARP2 is preferentially activated by poly(ADP-ribose) (PAR) and subsequently catalyzes branched PAR chain synthesis. PMID: 30104678
    2. data further suggest that ARTD2 would function in double strand break repair as a dimeric module, while in single strand break repair it would function as a monomer. PMID: 27708353
    3. Report a requirement for PARP2 in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1-dependent regulation of Rad51. Whereas PARP2 is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 in BER. PMID: 29467415
    4. PARP2 specifically limits the accumulation of the resection barrier factor 53BP1 at DNA damage sites, allowing efficient CtIP-dependent DNA end-resection PMID: 29036662
    5. either PARP1 or PARP2 are sufficient for near-normal XRCC1 recruitment at oxidative single-strand breaks PMID: 27965414
    6. Studies indicate that poly(ADP-ribose) polymerase 2 (PARP2) is involved in the differentiation of several cell types, including erythrocytes, T cells and adipocytes. PMID: 27087568
    7. Findings indicate that Increased poly(ADP-ribose) polymerase-2 (PARP-2) expression and loss of micrRNA miR-149 expression are involved in the pathogenesis of hepatocellular carcinomas (HCC) and are poor prognosis factors in patients with HCC. PMID: 27300349
    8. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt/beta-catenin signaling addicted tumors. PMID: 26513298
    9. The initial affinity between the PARP1, PARP2 and the DNA damaged site appears to influence both the size of the Poly(ADP-Ribose) synthesized and the time of residence of PARylated PARP1 and PARP2 on DNA damages. PMID: 26673720
    10. Our data suggest for the first time that a SNP in PARP2, rs878156, may together with other genetic variants modulate cancer specific survival in breast cancer patients depending on chemotherapy PMID: 26674097
    11. Our study differentiates the functions of PARP-2 domains from those of PARP-1, the other major DDR-PARP, and highlights the specialization of the multi-domain architectures of DDR-PARPs. PMID: 26704974
    12. Interaction of PARP-2 with AP site containing DNA PMID: 25724268
    13. Identification of ADP-ribosylation sites in PARP2 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed. PMID: 25800440
    14. Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFB signaling. PMID: 25133494
    15. the depletion of PARP-2 leads to lower HDL levels which represent a risk factor to cardiovascular diseases. PMID: 24365238
    16. these findings propose a novel mechanism of PARP-2 in transcriptional regulation involving specific protein-protein interactions and highlight the importance of PARP-2 in the regulation of cell cycle progression. PMID: 23291187
    17. PARP-1 (but not PARP-2) poly(ADP) ribosylates Snail1, both in vivo and in vitro, and interacts with Snail1, an association that is sensitive to PARP inhibitors. PMID: 21577210
    18. In complex with its inhibitor, the crystal structure of PARP2 alpha-helix 5 that contains glutamate residue Glu335 is closer to the active site than in both PARP1 and PARP3 and suggests a mechanism for a weak bias toward PARP2. PMID: 20092359
    19. The PARP-2 gene might be associated with azoospermia by meiotic arrest PMID: 19806447
    20. PARP-1 and PARP-2 act as positive regulators of genomic stability in eukaryotic cells by counteracting topoisomerase I-induced DNA damage PMID: 14699148
    21. PARP-2 and PARP-1 interact with TTF-1 and regulate the expression of surfactant protein B, a protein required for lung function PMID: 16461352
    22. cells from old subjects show a constitutive expression level of both parp 1 and parp 2 genes reduced by a half PMID: 17518695
    23. Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation. PMID: 18339380
    24. PARP-1-but not PARP-2-is required for proper expression of major genes involved in regulation of apoptosis PMID: 18587655
    25. Results provide strong evidence that lysine 36 of PARP-2 is a critical residue for proper nuclear targeting of PARP-2 and consequently for the execution of its biological functions. PMID: 18644123
    26. The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha PMID: 18676401

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome.
  • 組織特異性:
    Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine
  • 數據庫鏈接:

    HGNC: 272

    OMIM: 607725

    KEGG: hsa:10038

    STRING: 9606.ENSP00000250416

    UniGene: Hs.409412



主站蜘蛛池模板: 337人体做爰大胆视频| 天堂资源中文最新版在线一区| 日韩精品久久久久久久电影蜜臀| 久久亚洲精品成人av无码网站| 日本又黄又潮娇喘视频| 无码专区视频精品老司机| 18禁真人抽搐一进一出免费| 国产在线一区二区香蕉 在线| 色一情一乱一伦麻豆| 国产精品久久久久9999赢消| 香港台湾经典三级a视频| 亚洲精品久久yy5099| 午夜性爽视频男人的天堂| 牲交欧美兽交欧美| 欧美疯狂做受xxxx高潮| 国产肥熟女视频一区二区三区| 日日av色欲香天天综合网| 婷婷四虎东京热无码群交双飞视频| 亚洲中文无码人a∨在线| 色吊丝中文字幕| 国产成人a亚洲精v品无码| 亚洲精品久久久www| 久久精品成人免费国产片小草| 久久99亚洲精品久久69| 丝袜 亚洲 另类 欧美 变态| 国产女人的高潮国语对白| 四虎一区二区成人免费影院网址| 免费的av网站在线观看国产精品| 国产精品亚洲а∨天堂123| 欧美黑人乱大交| 波多野结衣久久一区二区| 国模无码一区二区三区不卡| 国语精品自产拍在线观看网站| 国产婷婷色一区二区三区| 曰韩无码av片免费播放不卡| 国产丝袜无码一区二区视频| 一边摸一边叫床一边爽av| 18禁免费无码无遮挡不卡网站| 精品无码一区二区三区不卡| 蜜桃日本免费观看mv| 亚洲成av人片在线观l看福利1|