在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PARN Antibody

  • 中文名稱:
    PARN兔多克隆抗體
  • 貨號:
    CSB-PA017456GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PARN
  • 別名:
    DAN antibody; Deadenylating nuclease antibody; Deadenylation nuclease antibody; PARN antibody; PARN_HUMAN antibody; Poly A specific ribonuclease antibody; Poly(A) specific ribonuclease antibody; Poly(A)-specific ribonuclease PARN antibody; Polyadenylate specific ribonuclease antibody; Polyadenylate-specific ribonuclease antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PARN
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability.
  • 基因功能參考文獻:
    1. Results show that PARN deadenylase activity is regulated by the phosphorylated form of Nucleolin. PMID: 29168431
    2. Studies suggest that the effects of poly(A)-specific ribonuclease (PARN) mutations on telomere length are likely indirect and may lead to telomere shortening that less perfectly cosegregates with heterozygous mutations. PMID: 26908837
    3. Pulmonary fibrosis patients with mutations in telomerase reverse transcriptase, telomerase RNA component, regulator of telomere elongation helicase 1 and poly(A)-specific ribonuclease were identified and clinical data were analysed. Genetic mutations in telomere related genes lead to a variety of interstitial lung disease diagnoses that are universally progressive. PMID: 27540018
    4. PARN polyadenylates the 3' end of telomerase RNA component (known as TERC or hTR), which serves as the template for telomerase reverse transcriptase-mediated telomere replication. PMID: 28414520
    5. PARN is a new component of the ribosome biogenesis machinery in human cells. PMID: 28402503
    6. provide evidence that PARN can also deadenylate the U6 and RMRP RNAs without affecting their levels PMID: 28760775
    7. poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells PMID: 27899605
    8. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 and the poly(A)-specific RNase PARN. PMID: 26628368
    9. PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10. PMID: 26950371
    10. Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination. PMID: 26342108
    11. results highlight the clinical significance of PARN and NOC on the survival in SCC diagnosed patients. PMID: 26541675
    12. Mutations in the PARN gene cause dyskeratosis congenital. PMID: 26482878
    13. The results indicate that the cellular level of miR-122 is determined by the balance between the opposing effects of GLD-2 and PARN/CUGBP1 on the metabolism of its 3'-terminus. PMID: 26130707
    14. 3 families with dyskeratosis congenita had key domain mutations in PARN shortening telomeres, reducing deadenylation, and downregulating TERC, DKC1, RTEL1, and TERF1. PMID: 25893599
    15. PARN and RTEL1 mutation carriers had shortened leukocyte telomere lengths. PMID: 25848748
    16. poly(A)-specific ribonuclease (PARN) was upregulated in gastric tumor tissues and gastric cancer cell lines MKN28 and AGS. PMID: 25499764
    17. Both R3H and RRM domains were essential for the high affinity of long poly(A) substrate. PMID: 23388391
    18. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus PMID: 22727665
    19. The atomic force microscopy images of single PARN molecules reveal compact ellipsoidal dimers (10.9 x 7.6 x 4.6nm). PMID: 21741754
    20. PARN harbors specificity for adenosine recognition in its active site and that the nucleotides surrounding the scissile bond are critical for adenosine recognition. PMID: 19901024
    21. residues of human PARN, Asp(28), Glu(30), Asp(292), and Asp(382), are essential for catalysis but are not required for stabilization of the PARN x RNA substrate complex. PMID: 11742007
    22. Results show that tristetraprolin can promote the deadenylation of AU-rich element (ARE)-containing, polyadenylated substrates by poly(A) RNase. PMID: 12748283
    23. study of binding and coordination of divalent metal ions in the active site of PARN PMID: 15358788
    24. The crystal structure of C-terminal truncated human PARN determined in two states (free and RNA-bound forms) reveals that PARN is folded into two domains, an R3H domain and a nuclease domain PMID: 16281054
    25. CUG-BP binds specifically to both of these RNAs and stimulates poly(A) shortening by PARN. Moreover, CUG-BP interacts with PARN in extracts by coimmunoprecipitation, and this interaction can be recapitulated using recombinant proteins PMID: 16601207
    26. The entire RNA-recognition motif (RRM) domain not only contributes to the substrate binding and efficient catalysis of PARN, but also stabilizes the overall structures of the protein. PMID: 17391638
    27. REsults describe the crystal structure of the poly(A)-specific ribonuclease (PARN)-RRM domain with a bound 7-methylguanosine triphosphate nucleotide, revealing a novel binding mode for the m(7)G cap. PMID: 18694759
    28. PARN is an allosteric enzyme, and potassium ions and the cap analogue are effectors with binding sites located at the RRM domain. PMID: 19103158
    29. Xenopus oocytes contain cytoplasmic (p62) and nuclear (p74) isoforms of PARN. p62 is proteolytically derived from p74. Both isoforms are expressed throughout oogenesis and early development. PMID: 11424938
    30. The m7GpppG cap has multiple effects on PARN activity. In cis, the 5'cap stimulates deadenylation by increasing PARN processivity. In trans, low concentrations of cap stimulate PARN activity whereas high concentrations inhibit deadenylation. PMID: 11359775
    31. PARN is a poly(A)-specific member of the RNase D family of 3' exoribonucleases. It is distributed between the nucleus and the cytoplasm and is not stably associated with ribosomes. Xenopus PARN catalyzes deadenylation during oocyte maturation. PMID: 9736620
    32. Deadenylation by the mammalian and amphibian poly(A)-specific exoribonuclease, PARN, is stimulated by the presence of an m(7)-guanosine cap on substrate RNAs. PARN exhibits intrinsic cap-binding activity. PMID: 10698948
    33. PARN binds to the 5' cap on substrate mRNAs. Cap-binding is stimulated by a poly(A) tail and competed by eIF4E. Cap-PARN interactions integrate regulated mRNA stability and translation. PMID: 10882133

    顯示更多

    收起更多

  • 相關疾病:
    Dyskeratosis congenita, autosomal recessive, 6 (DKCB6); Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 4 (PFBMFT4)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.
  • 蛋白家族:
    CAF1 family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 8609

    OMIM: 604212

    KEGG: hsa:5073

    STRING: 9606.ENSP00000387911

    UniGene: Hs.253197



主站蜘蛛池模板: 精产国品一二三产区9977| 免费中文字幕日韩欧美| 天堂在/线资源中文在线| 久久99精品国产99久久6尤物| 精品高朝久久久久9999| 欧洲专线一区二区三区| 嫩草伊人久久精品少妇av| 欧美老熟妇videos极品另类| 中文字幕精品久久久久人妻红杏ⅰ | 东京热一区二区三区无码视频| 国产xxxx做受性欧美88| 亚洲色老汉av无码专区最| 免费永久在线观看黄网站| 国产高清乱理伦片中文小说| 三级4级全黄60分钟| 亚洲 精品 制服 校园 无码| 国精品99久9在线 | 免费| 天堂а√8在线最新版在线| 牛牛视频一区二区三区| 高大丰满熟妇丰满的大白屁股| 精品麻豆丝袜高跟鞋av| 无人去码一码二码三码区| 国产69精品久久久久人妻| 亚洲午夜精品a片久久www慈禧| 午夜成人无码片在线观看影院| 亚洲一区二区三区国产精品无码| 最新高清无码专区| 东北女人毛多水多牲交视频| 四虎影视精品永久在线观看 | 无码人妻丝袜在线视频红杏| 无码潮喷a片无码高潮视频| 精品国产sm最大网免费站| 国产精品国产成人国产三级| 日本少妇三级hd激情在线观看| 伊人久久精品无码av一区| 日本熟妇浓毛| 在线看片无码永久av| 熟妇丰满大屁股在线播放| 亚洲人毛茸茸bbxx| 青青青伊人色综合久久| 人妻少妇精品视频无码专区|