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  4. PANK1 Antibody, Biotin conjugated

PANK1 Antibody, Biotin conjugated

  • 中文名稱：
    PANK1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA017421LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PANK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PANK1
  • 別名：
    coaA antibody; hPanK antibody; hPanK1 antibody; PANK antibody; PANK1 antibody; PANK1_HUMAN antibody; PANK1a antibody; PANK1b antibody; PanK1beta antibody; Pantothenate kinase 1 antibody; Pantothenate kinase antibody; Pantothenic acid kinase 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Pantothenate kinase 1 protein (462-582AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
  • 基因功能參考文獻：
    1. p53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1. PMID: 23343762
    2. PANK deficiency leads to abnormalities in F-actin organization. PMID: 22912811
    3. molecular cloning and characterization of a new human PanK gene PMID: 11809413
    4. alternative splicing product PMID: 12379284
    5. PPARalpha transcription factor as a major factor governing hepatic CoA levels by specific modulation of PANK1alpha gene expression PMID: 14523052
    6. analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration PMID: 17631502

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  • 亞細胞定位：
    Cytoplasm.; [Isoform 1]: Nucleus. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.
  • 蛋白家族：
    Type II pantothenate kinase family
  • 組織特異性：
    [Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis.; [Isoform 2]: Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle.
  • 數據庫鏈接：

    HGNC: 8598

    OMIM: 606160

    KEGG: hsa:53354

    STRING: 9606.ENSP00000302108

    UniGene: Hs.163555



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