在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PACS2 Antibody
  • 中文名稱：
    PACS2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA017372LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA017372LA01HU diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA017372LA01HU diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PACS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PACS2
  • 別名：
    6720425G15Rik antibody; AW208651 antibody; AW489976 antibody; E230011J22 antibody; FLJ25488 antibody; KIAA0602 antibody; mKIAA0602 antibody; PACS 2 antibody; PACS-2 antibody; PACS1 like protein antibody; PACS1-like protein antibody; PACS1L antibody; PACS2 antibody; PACS2_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 like antibody; Phosphofurin acidic cluster sorting protein 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphofurin acidic cluster sorting protein 2 protein (268-465AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，PACS2 Antibody (CSB-PA017372LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PACS2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA017372LB01HU PACS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA017372LC01HU PACS2 Antibody, FITC conjugated
    Biotin CSB-PA017372LD01HU PACS2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
  • 基因功能參考文獻(xiàn)：
    1. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis. PMID: 29656858
    2. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
    3. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    4. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells PMID: 24633224
    5. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
    6. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2. PMID: 22645134
    7. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
    8. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis PMID: 15692567
    9. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system PMID: 18296443
    10. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane PMID: 18417615
    11. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action. PMID: 19481529

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum. Mitochondrion.
  • 蛋白家族：
    PACS family
  • 組織特異性：
    Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 23794

    OMIM: 610423

    KEGG: hsa:23241

    STRING: 9606.ENSP00000393559

    UniGene: Hs.525626



主站蜘蛛池模板： 久久综合久久鬼色| 美女视频黄的全免费视频网站| 免费全部高h视频无码| 日产精品1区2区3区| 婷婷色综合视频在线观看| 在线a久青草视频在线观看| 亚洲性啪啪无码av天堂| 无码人妻精品中文字幕| 女人裸露免费视频无遮挡网站| 国产未成女一区二区| 与子敌伦刺激对白播放| 性xxxx视频播放免费| 亚洲欧美丝袜精品久久 | 国产私拍大尺度在线视频| 中国肥老太婆高清video| 国产一区二区亚洲精品| 无码精品黑人一区二区三区| 国产精品十八禁在线观看| 成年女人免费v片| 男女做爰猛烈啪啪吃奶动| 浪货趴办公桌～h揉秘书电影| 国产成人综合色就色综合| 亚洲日本一区二区一本一道| www亚洲精品久久久| 2018高清日本一道国产-在| 老头把我添高潮了a片| 伊人情人综合网| 国产无夜激无码av毛片| 亚洲人成电影综合网站色www | 深夜福利视频在线播放| 人人妻一区二区三区| 人妻一区二区三区高清av专区| 欧洲一卡2卡3卡4卡乱码视频 | 99久在线国内在线播放免费观看 | 国产啪精品视频网站免| 人人爽人人爱| 国产乱子轮xxx农村| 成人午夜高潮免费视频在线观看 | 爽爽影院免费观看| 久久综合给综合给久久| 无码精品人妻一区二区三区av|