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  4. PACS2 Antibody
  • 中文名稱：
    PACS2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA017372LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA017372LA01HU diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA017372LA01HU diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PACS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PACS2
  • 別名：
    6720425G15Rik antibody; AW208651 antibody; AW489976 antibody; E230011J22 antibody; FLJ25488 antibody; KIAA0602 antibody; mKIAA0602 antibody; PACS 2 antibody; PACS-2 antibody; PACS1 like protein antibody; PACS1-like protein antibody; PACS1L antibody; PACS2 antibody; PACS2_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 like antibody; Phosphofurin acidic cluster sorting protein 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphofurin acidic cluster sorting protein 2 protein (268-465AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，PACS2 Antibody (CSB-PA017372LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PACS2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA017372LB01HU PACS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA017372LC01HU PACS2 Antibody, FITC conjugated
    Biotin CSB-PA017372LD01HU PACS2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
  • 基因功能參考文獻(xiàn)：
    1. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis. PMID: 29656858
    2. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
    3. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    4. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells PMID: 24633224
    5. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
    6. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2. PMID: 22645134
    7. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
    8. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis PMID: 15692567
    9. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system PMID: 18296443
    10. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane PMID: 18417615
    11. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action. PMID: 19481529

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum. Mitochondrion.
  • 蛋白家族：
    PACS family
  • 組織特異性：
    Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 23794

    OMIM: 610423

    KEGG: hsa:23241

    STRING: 9606.ENSP00000393559

    UniGene: Hs.525626



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