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  4. PACS1 Antibody, HRP conjugated

PACS1 Antibody, HRP conjugated

  • 中文名稱：
    PACS1兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA017371LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PACS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PACS1
  • 別名：
    Cytosolic sorting protein PACS1 antibody; PACS 1 antibody; PACS-1 antibody; Pacs1 antibody; PACS1_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphofurin acidic cluster sorting protein 1 protein (757-905AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
  • 基因功能參考文獻：
    1. Using whole exome sequencing (WES), we identified eight additional individuals with the same p.Arg203Trp missense variant in PACS1 that we demonstrated were de novo in seven individuals with available parental DNA. PMID: 28111752
    2. PCAF and ADA3 transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis. PMID: 28060382
    3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
    4. study showed for the first time that the rs564343 in phosphofurin acidic cluster sorting protein 1(PACS1) was associated with risk of severe obesity in Chinese children PMID: 28564656
    5. Clinical description of the PACS1-related syndrome has been reported in 19 unrelated patients. PMID: 26842493
    6. PACS1 plays an important role in protein sorting for amyloidogenic-burden control via both SORLA-dependent and SORLA-independent mechanisms. PMID: 24001769
    7. Single nucleotide polymorphisms in PAKS1 gene is associated with obesity. PMID: 23563609
    8. Our findings suggest that PACS1 is necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic ID phenotype. PMID: 23159249
    9. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
    10. PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC-I to the trans-Golgi network and usurping the ARF6 endocytic pathway PMID: 12526811
    11. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
    12. casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia PMID: 16308564
    13. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported. PMID: 16977309
    14. PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b in olfactory sensory neurons. PMID: 19710307

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  • 相關疾病：
    Schuurs-Hoeijmakers syndrome (SHMS)
  • 亞細胞定位：
    Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    PACS family
  • 數據庫鏈接：

    HGNC: 30032

    OMIM: 607492

    KEGG: hsa:55690

    STRING: 9606.ENSP00000316454

    UniGene: Hs.644326



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