在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PA2G4 Antibody

  • 中文名稱:
    PA2G4兔多克隆抗體
  • 貨號:
    CSB-PA891987LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
      All lanes: PA2G4 antibody at 2.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 44, 39 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA891987LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA891987LA01HU at dilution of 1:100
    • Immunofluorescence staining of MCF-7 cells with CSB-PA891987LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PA2G4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PA2G4
  • 別名:
    38kDa antibody; AA672939 antibody; Cell cycle protein p38 2G4 homolog antibody; Cell cycle protein p38-2G4 homolog antibody; ErbB-3 binding protein 1 antibody; ErbB3 binding protein 1 antibody; ErbB3-binding protein 1 antibody; ErbB3-binding protein Ebp1 antibody; hG4 1 antibody; hG4-1 antibody; IRES-specific cellular trans-acting factor 45 kDa antibody; MGC81621 antibody; MGC94070 antibody; Mpp1 antibody; p38 2G4 antibody; Pa2g4 antibody; PA2G4_HUMAN antibody; Plfap antibody; Proliferation associated 2G4 antibody; Proliferation associated 2G4; 38-KD antibody; Proliferation-associated 2G4; 38kDa antibody; Proliferation-associated 2G4; a antibody; Proliferation-associated protein 1 antibody; Proliferation-associated protein 2G4 antibody; Protein p38-2G4 antibody; si:dz150i12.2 antibody; wu:fb19b11 antibody; wu:ft56d05 antibody; zgc:86732 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Proliferation-associated protein 2G4 protein (2-394AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PA2G4 Antibody (CSB-PA891987LA01HU),的標記方式是Non-conjugated。對于PA2G4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA891987LB01HU PA2G4 Antibody, HRP conjugated ELISA
    FITC CSB-PA891987LC01HU PA2G4 Antibody, FITC conjugated
    Biotin CSB-PA891987LD01HU PA2G4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.
  • 基因功能參考文獻:
    1. Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. PMID: 30224479
    2. In this study, the authors demonstrated that overexpression of ErbB3-binding protein 1 (EBP1) promoted not only a reduction of wild type of p85 subunit of phosphoinositide 3-kinase but also oncogenic mutant forms of p85 which were identified in human cancers. PMID: 27464702
    3. The results demonstrate an important role of Ebp1 in promoting cell proliferation in Acute Myelogenous Leukemic Cells through the regulation of both rRNA synthesis and Proliferating Cell Nuclear Antigen expression. PMID: 26813358
    4. results show that EBP1 interacts directly with PPIns and associate with PtdIns(3,4,5)P3 in the nucleolus. PMID: 27118868
    5. The adapter function of EBP1 P42 stabilized the interaction of FBXW7 with its substrates and promoted FBXW7-mediated degradation of oncogenic targets, enhancing its overall tumor-suppressing function. Results establish distinct physical and functional interactions between FBXW7 and EBP1 isoforms, which yield their mechanistically unique isoform-specific functions of EBP1 in cancer. PMID: 28209614
    6. The combined determination of Ebp1 and p53 expression levels in cervical cancer patients could support the effective prediction of metastatic potential and patient prognosis. PMID: 26436510
    7. Data highlight the tissue specificity function of EBP1 isoforms and show that only the oncogene p48 activates MHC II expression in human solid tumors, via STAT1 phosphorylation, in order to affect tumor progression by triggering specific immune response. PMID: 26081906
    8. Our results suggest a novel function of Ebp1 as a binding protein and negative regulator of Anxa2. The functional association between Anxa2 and EBP1 may participate in regulating cancer cell proliferation and invasion, contributing to cancer progression. PMID: 25917452
    9. Ebp1 functionality is independent from heat-shock-protein-regulated progression networks in prostate cancer. PMID: 24798454
    10. P48Ebp1 acts as an oncoprotein. PMID: 25154617
    11. EBP1 participates in the regulation of intestinal inflammation via mediating Akt signaling pathway. PMID: 26256794
    12. Data suggest that inhibiting ErbB3-binding protein 1 Ebp1 phosphorylation may be an effective mechanism for inhibiting T-cell activation and proliferation. PMID: 25691158
    13. Ebp1 p42 isoform regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. PMID: 24651434
    14. data suggest that Vpr may inhibit Ebp1 to stabilize p53, which in turn leads to G2 arrest and apoptosis in U87MG cells PMID: 23828502
    15. identified among endothelial antigens to which antibodies are produced during heart transplant rejection PMID: 23707440
    16. The major effect of EBP1 on ErbB2 mRNA expression levels is at the transcriptional level. PMID: 23242156
    17. Down-regulation of the ErbB3 binding protein 1 in human bladder cancer promotes tumor progression and cell proliferation. PMID: 23283744
    18. Performed immunohistochemical analysis on 132 primary adenoid cystic carcinoma and adjacent non-cancerous tissues.The expression of EBP1 was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues. PMID: 23110497
    19. It was shown that high level of Ebp1 expression led to enhancee HDM2 phosphorylation by Akt and inhibited the self-ubiquitination of HDM2 by up-regulation of Akt activity. PMID: 21930127
    20. the Ebp1 promoter localizes between -664 nt and the initiation site of the Ebp1 gene, +317-nt long sequence in the noncoding region is required for regulation of Ebp1 gene expression. PMID: 21794029
    21. These studies suggest that one pathway of EBP1 down-regulation of AR levels may be lost in castration-resistant prostate cancer. PMID: 21965718
    22. Ebp1 contributes to neuronal cell differentiation and growth factor specificity through the activation of protein kinase Cdelta acting as a crucial downstream effector of neurotrophin signaling. PMID: 21145366
    23. Ablation of EBP1 expression led to tamoxifen resistance in breast cancer. PMID: 20379846
    24. Data show that E2F is likely a central coordinator of multiple responses that culminate in regulation of EBP1 gene expression, and which may vary depending on cell type and context. PMID: 21085677
    25. Findings suggest that eBP1 p48 functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to p53 downregulation. PMID: 21098709
    26. our results reveal an EBP1-Foxa-AGR2 signaling circuit with functional significance in metastatic prostate cancer PMID: 20048076
    27. EBP1 is in the cytoplasm & nucleolus. Nucleolar localization requires AA sequences at the NH2- and COOH-ends. Overexpression inhibits proliferation of human fibroblasts. It is part of RNP complexes & associates with different rRNAs. PMID: 15064750
    28. ErbB3-binding protein Ebp1 binding to E2F promoter elements and E2F-mediated transcription are regulated by heregulin. PMID: 15073182
    29. These studies suggest that Ebp1 is an AR corepressor whose biological activity can be regulated by the ErbB3 ligand, HRG. PMID: 15583694
    30. Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. PMID: 15994225
    31. Ebp1 is present in protein-ARE(bcl-2) RNA complexes. Ebp1 & nucleolin are present in the same bcl-2 mRNP complexes. Ebp1 decreases the rate of decay of beta-globin-ARE(bcl-2) transcripts. Ebp1 contributes to bcl-2 expression regulation in HL-60 cells. PMID: 16396631
    32. Our results demonstrate that Ebp1 is a new dsRNA-binding protein that acts as a cellular inhibitor of eIF2alpha phosphorylation suggesting that it could be involved in protein translation control PMID: 16631606
    33. over-expression of Ebp1 interfered with virus production PMID: 17295834
    34. PKC-delta antagonizes apoptosis through phosphorylating Ebp1 and protects it from apoptotic degradation. PMID: 17316401
    35. ErbB-3-binding protein-1 is an immunogenic protein with cancer-related immunoreactivity, capable of eliciting CD8-positive T cell-mediated responses in vivo and in vitro. PMID: 17641068
    36. The structure provides insights in how Ebp1 discriminates between its different interaction partners. PMID: 17765895
    37. ErbB-3-binding protein 1 (Ebp1) is a member of the family of proliferation-associated 2G4 proteins (PA2G4s) and plays a role in cellular growth and differentiation. PMID: 17768350
    38. These results suggest that EBP1, by down-regulating ErbB signal transduction, attentuates HRG-mediated growth of breast cancer cells. PMID: 18355957
    39. These data support a role for EBP1 in the development of hormone-refractory prostate cancer. PMID: 18852121
    40. hBre1 inhibits Ebp1's tumor suppressive activity through mediating its polyubiquitination and degradation. PMID: 19037095

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Peptidase M24 family
  • 組織特異性:
    Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
  • 數據庫鏈接:

    HGNC: 8550

    OMIM: 602145

    KEGG: hsa:5036

    STRING: 9606.ENSP00000302886

    UniGene: Hs.524498



主站蜘蛛池模板: 好想被狂躁无码视频在线观看| 亚洲国产精品久久亚洲精品| 97免费公开在线视频| 国产在线午夜不卡精品影院 | 男人用嘴添女人私密视频| 中文人妻熟妇乱又伦精品| 亚洲sm另类一区二区三区| 丰满熟妇乱子伦| 青青青伊人色综合久久| 精品噜噜噜噜久久久久久久久| 色 成人 亚洲| 蜜桃少妇av久久久久久久| 东北老女人高潮大叫对白| 少妇一边呻吟一边说使劲视频| 少妇愉情理伦片丰满丰满午夜| 无码国产成人午夜电影观看| 欧美在线精彩视频免费播放| 久久欧美一区二区三区性生奴| 日本大胆欧美人术艺术| 亚洲精品无码久久毛片| 夜夜天天噜狠狠爱2019| 熟女人妻视频| 无码人妻视频一区二区三区| 免费现黄频在线观看国产| 欧美日产国产精品日产| 少妇被躁爽到高潮无码久久| 久久国产欧美日韩精品图片| 一本一道久久综合久久| 人妻熟妇乱又伦精品视频| 99精品无人区乱码在线观看| 色8激情欧美成人久久综合电影| 激情综合色综合啪啪五月丁香搜索 | 人人爽久久久噜噜噜婷婷| 内射爽无广熟女亚洲| 无码精品一区二区三区在线| 久久久久精品无码一区二区三区| 久久99精品久久久久久蜜芽 | 一本一道色欲综合网中文字幕| 亚洲中文字幕久久精品蜜桃| 又大又紧又粉嫩18p少妇| r级无码视频在线观看|