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P4hb Antibody, HRP conjugated

  • 中文名稱:
    P4hb兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA017342YB01MO
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) P4hb Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    P4hb antibody; Pdia1Protein disulfide-isomerase antibody; PDI antibody; EC 5.3.4.1 antibody; Cellular thyroid hormone-binding protein antibody; Endoplasmic reticulum resident protein 59 antibody; ER protein 59 antibody; ERp59 antibody; Prolyl 4-hydroxylase subunit beta antibody; p55 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Protein disulfide-isomerase protein (20-509AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
  • 基因功能參考文獻:
    1. Unfolded protein response caused by protein misfolding, may lead to PDI-dependent NOX activation and contribute to neurotoxicity in neurodegenerative diseases including ALS. PMID: 23118353
    2. PDI from endothelial cells is required for fibrin generation in vivo. PMID: 20668226
    3. Protein disulfide isomerase (PDI) on the platelet surface is recognized by anti-dengue virus NS1 antibodies. PMID: 19822367
  • 亞細胞定位:
    Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein disulfide isomerase family
  • 數據庫鏈接:


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