在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

P2RY2 Antibody

  • 中文名稱:
    P2RY2兔多克隆抗體
  • 貨號:
    CSB-PA972644
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA972644(P2RY2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA972644(P2RY2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    P2RY2; P2RU1; P2Y purinoceptor 2; P2Y2; ATP receptor; P2U purinoceptor 1; P2U1; P2U receptor 1; Purinergic receptor
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human P2RY2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
  • 基因功能參考文獻:
    1. Study demonstrated that the P2Y2 receptor was highly expressed in MCF7 and Hs578T breast cancer cells and indicated that the P2Y2 receptor promoted cell migration and invasion in breast cancer cells via EMT-related genes Snail and E-cadherin. PMID: 29115551
    2. Our results clearly demonstrate the involvement of P2Y2R subtypes in the pathogenesis of fibrotic lung diseases in humans and mice and hence support the development of selective P2Y2R antagonists for the treatment of IPF. PMID: 28415591
    3. Proliferation and migration of functionally impaired cardiac progenitor cells are enhanced by P2Y2R-mediated YAP activation, revealing a novel link between extracellular nucleotides released during injury/stress and Hippo signaling-a central regulator of cardiac regeneration. PMID: 28923792
    4. nterleukin-8 release after purinergic stimulation in ALI-cultured HEECs is mediated through P2Y2 receptor activation. PMID: 27977904
    5. Human umbilical vein endothelial cells exposed to either P2Y2 receptor antagonists or siRNA showed impaired fluid shear stress-induced cell alignment, and actin stress fiber formation as early as 6 h. PMID: 27652381
    6. There is increased expression of P2Y2 receptors in the rectosigmoid mucosa of diarrhea-predominant irritable bowel syndrome patients. P2Y2 correlated with abdominal pain. PMID: 27250983
    7. A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
    8. Hypoxia and upregulated HIF-1a both upregulated the P2Y2 levels in hepatocellular carcinoma cells and increased their survival. PMID: 27807254
    9. Results show that purinergic receptor P2Y2 (P2Y2R) requires N-glycosylation for expression on the cell surface. PMID: 28209512
    10. Data indicate that knockdown of caveolin-1 (Cav-1) expression causes redistribution of the P2Y2 nucleotide receptor (P2Y2R) from membrane rafts. PMID: 27129210
    11. The P2RY2 receptor induces carcinoma cell migration and epithelial-mesenchymal transition through cross-talk with EGFR. PMID: 26443721
    12. Activation of P2Y2R increased TF promoter activity and mRNA expression in coronary artery endothelial cells. PMID: 26631725
    13. Data show that the purinergic receptor P2Y2 (P2Y2R) pepducin activates neutrophils through formyl peptide receptor 2 (FPR2), and ATP is turned into an activating agonist through a receptor cross-talk mechanism that involves both FPR2 and P2Y2R. PMID: 26996596
    14. P2Y2 receptor and EGFR cooperate to promote prostate cancer cell invasion via ERK1/2 pathway. PMID: 26182292
    15. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
    16. These results suggest that over-activated ERK and PKC pathways are involved in the P2Y2R-mediated invasion of breast cancer cells. PMID: 26063340
    17. P2Y2 and Gq/G11 are required for basal endothelial NO formation, vascular tone, and blood pressure. PMID: 26168216
    18. P2Y2R may play an important role in cancer metastasis via modulation of the crosstalk between cancer cells and endothelial cells. PMID: 25156554
    19. These results demonstrate that P2Y2R plays an important role in activation of the HIF-1alpha-LOX axis, the induction of collagen crosslinking and the recruitment of CD11b+ hematopoietic bone marrow-derived cells. PMID: 25238333
    20. ATP increased P2Y-mediated upregulation of MUC8 expression; however, IL-1alpha significantly decreased the extent to which ATP/P2Y upregulated MUC8 expression. PMID: 25575516
    21. Signaling cascades evoked by P2Y2 receptor plays an important role in the phenomena dependent on the actin cytoskeleton dynamics endocy-tosis, cell division, adhesion, intracellular transport and migration.(review) PMID: 25807824
    22. P2Y2 receptor fails to repress IL-6 expression by valve interstitial cells through Akt in calcific aortic valve disease. PMID: 24631773
    23. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. PMID: 24716914
    24. siRNA against P2Y2R or RAGE, suggesting that P2Y2R is an important mediator in oxLDL-mediated monocyte adhesion to ECs through the regulation of ROS-dependent adhesion molecule expression in ECs. PMID: 24486339
    25. P2Y2 receptor deletion in transgenic mice increased Beta-amyloid plaque load and soluble AB1-42 levels in brain from Alzheimer's disease model animals. PMID: 24193664
    26. P2Y2R mediated the action of ATP on the cellular behavior of HCC cells through store-operated calcium channel-mediated Ca(2+) signaling PMID: 24847054
    27. reflected in the immunoblotting data P2RY2 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. PMID: 25003238
    28. P2Y2 overexpression elevates the inhibitory effect of extracellular ATP on the proliferation of nasopharyngeal carcinoma cells. PMID: 24961145
    29. The activation of P2Y2 receptors increases MCF-7 breast cancer cells migration through the MEK-ERK1/2 signalling pathway. PMID: 24390819
    30. decrease in Src Y421 and Y446 and paxillin Y118 was detected, indicating the far-reaching importance of the P2Y2 receptor in mediating migration. PMID: 24095926
    31. signals generated by the receptor for ATP (P2Y2) reactivate desensitized formyl peptide receptors (FPRs) so that these ligand-bound inactive FPRs resume signaling. PMID: 24491917
    32. Results suggest that P2Y2 receptor desensitization protects airways against the deleterious effects of persistent fluid secretion. PMID: 23757023
    33. Uridine triphosphate increases proliferation of cancerous pancreatic duct epithelial cells by activation of P2Y2 receptor and PI3K/Akt pathway. PMID: 23462325
    34. suggest the P2Y2 receptor and its endothelial downstream signaling mechanisms as a target for antimetastatic therapies PMID: 23810565
    35. In women, bone mineral density values at all sites were significantly different between the genotypes for the Leu46Pro polymorphism of the p2y2 receptor PMID: 22773251
    36. Activation of P2Y2R and Galphaq by uridine triphosphate promotes hemidesmosome formation. PMID: 22718344
    37. IL-8 and IL-6 release after purinergic stimulation in uroepithelial cells is mediated through P2V2 receptors activation. PMID: 23088987
    38. Data define the expression profile of P2Y receptors on human biliary epithelial cancer cells and indicate P2Y2 receptors as being potential targets in new treatment strategies for biliary cancer. PMID: 22993317
    39. Upon activation by ursolic acid , P2Y2 activated Src which in turn phosphorylated p38 leading to COX-2 overexpression which induced resistance to apoptosis in both colorectal and prostate cancer cells PMID: 22521508
    40. Adenosine triphosphate (ATP) enhances proliferation, adhesion, and migration via P2Y2R activation and the immunosuppressive ability of regulatory T (Treg) cells. PMID: 22753942
    41. estrogen, via estrogen alpha receptors, promotes proliferation of breast cancer cells by down-regulating purinergic receptor P2Y receptor expression thereby attenuating calcium signaling PMID: 21356271
    42. Inhibition of any of the constituents of this cascade (pannexin-1, ATP, P2Y2, and Pyk2) impairs the replication of HIV-1 mutant viruses that are resistant to conventional antiretroviral agents. PMID: 21859844
    43. P2Y(2) receptor mediates TF expression in HCAEC through new mechanisms involving Src/p38 and Rho/JNK pathways, possibly contributing to a pro-thrombotic status after vascular injury. PMID: 21652710
    44. A P2Y2 isoform represents the predominant purinergic receptor underlying ATP-evoked Ca2+ mobilization, membrane hyperpolarization and de novo synthesis of nitric oxide. PMID: 21414662
    45. P2Y(2) R appears to be involved in asthmatic airway inflammation PMID: 20880147
    46. Purinergic receptors might represent important new set of molecular targets for theca hyperplasia and polycystic ovarian syndrome. PMID: 20630102
    47. Data report that activation of P2Y(2) receptors by extracellular UTP inhibits the IGF-I-induced p110alpha-PI3K activation. PMID: 20089844
    48. P2Y2 is the key player in the response of corneal epithelial cells to cell damage and subsequent repair events. PMID: 20427708
    49. The rs4944831 and the T-A-G haplotype of the human P2RY2 gene might be genetic markers for essential hypertension in Japanese men. PMID: 19710694
    50. These results suggest that P2Y(2)R activation in salivary gland cells promotes the formation of EGFR/ErbB3 heterodimers and metalloprotease-dependent neuregulin 1 release, resulting in the activation of both EGFR and ErbB3. PMID: 20064929

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Spleen, testis, kidney, liver, lung, heart and brain.
  • 數據庫鏈接:

    HGNC: 8541

    OMIM: 600041

    KEGG: hsa:5029

    STRING: 9606.ENSP00000310305

    UniGene: Hs.339



主站蜘蛛池模板: 日韩人妻无码一区二区三区俄罗斯| 日本熟妇乱人伦xxxx| 久久精品国产一区二区免费| 中文字幕欧美亚州视频免费| 国产偷人爽久久久久久老妇app| 久久欧美国产伦子伦精品| 久久精品99av高久久精品 | 真实国产乱子伦精品一区二区三区| 97精品尹人久久大香线蕉| 色婷婷香蕉在线一区二区| 蜜臀av无码精品人妻色欲| 国产成人一区二区三区别 | 亚洲欧美人成网站在线观看看| 国产亚洲精品久久77777| 国产真实乱人偷精品人妻| 色五月丁香五月综合五月4438| 丁香五月婷激情综合第九色| 国产午夜鲁丝片av无码免费| 国产精品激情| 少妇人妻互换不带套| 亚洲中文字幕婷婷在线| 亚洲国产精品无码久久久蜜芽| 亚洲精品毛片一区二区三区| 久久人人爽人人爽人人片| 一本久久a久久精品综合| 国产又爽又黄又刺激的视频| av电影在线观看| 中文字幕乱码免费看电影| 亚洲欧洲日产最新| 人人妻人人超人人| 亚洲性啪啪无码av天堂| 免费无码一区二区三区a片| 国产麻豆精品精东影业av网站 | 国产又粗又硬又大爽黄老大爷视频 | 丁香五月欧美成人| 国产精品宾馆精品酒店| 亚洲顶级裸体av片| 日韩无套无码精品| 精品人妻无码专区中文字幕| 免费高清av一区二区三区| 亚洲狠狠做深爱婷婷影院|