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  4. OVOL2 Antibody, Biotin conjugated

OVOL2 Antibody, Biotin conjugated

  • 中文名稱：
    OVOL2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA887110HD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OVOL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OVOL2
  • 別名：
    bA504H3.3 antibody; EUROIMAGE566589 antibody; hOvo 2 antibody; hOvo2 antibody; Ovo like 2 (Drosophila) antibody; Ovo like 2 antibody; ovo-like zinc finger 2 antibody; OVOL 2 antibody; OVOL2 antibody; OVOL2_HUMAN antibody; Transcription factor Ovo like 2 antibody; Transcription factor Ovo-like 2 antibody; Zinc finger protein 339 antibody; ZNF 339 antibody; ZNF339 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription factor Ovo-like 2 protein (19-114AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos.
  • 基因功能參考文獻：
    1. Taken together, this study suggests that the OVOL1-OVOL2 axis is a key modulator of c-Myc expression in the shift from in situ epidermal malignancy (Bowen's disease) to invasive squamous cell carcinoma. PMID: 28339425
    2. OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis. PMID: 28455959
    3. the OVOL2 promoter variant c.-307T>C was herein identified in the original family that established the posterior polymorphous corneal dystrophy 1 locus. PMID: 28046031
    4. OVOL2 maintains the transcriptional program of human corneal epithelium cells. PMID: 27134177
    5. hOvol2 expression was restricted to the XY body of spermatocytes at the pachytene stage. This study demonstrates that hOvol2 is expressed in germ cells and may be involved in spermatogenesis. PMID: 27136193
    6. Ovol2 can suppress migration and invasion ability of A549 cells, and prevent EMT by inhibition of Twist1 transcription directly. PMID: 27884772
    7. congenital hereditary endothelial dystrophy 1 (CHED1) and CHED2 loci on chromosome 20 and the collagen, type VIII, alpha-2 (COL8A2) gene were excluded by linkage and haplotype analyses. PMID: 12654361
    8. We report the absence of a presumed pathogenic coding region mutation in the common PPCD1 support interval. PMID: 19574904
    9. that the OVOL1-OVOL2 axis may actively contribute to cell differentiation and proliferation in the hair bulb PMID: 26873447
    10. OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex. PMID: 26619963
    11. data demonstrate that all four mutated OVOL2 promoters exhibited more transcriptional activity than the corresponding wild-type promoter PMID: 26749309
    12. Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions in humans and other species PMID: 22737237
    13. Ovol2 directly represses two critical downstream targets, c-Myc and Notch1, thereby suppressing keratinocyte transient proliferation and terminal differentiation, respectively PMID: 19700410

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  • 相關疾病：
    Corneal dystrophy, posterior polymorphous, 1 (PPCD1)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed in testis, ovary, heart and skeletal muscle. Expressed in the cornea, but absent from the corneal endothelium.
  • 數據庫鏈接：

    HGNC: 15804

    OMIM: 122000

    KEGG: hsa:58495

    STRING: 9606.ENSP00000278780

    UniGene: Hs.661013



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