在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. OTULIN Antibody, Biotin conjugated

OTULIN Antibody, Biotin conjugated

  • 中文名稱：
    OTULIN兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA853391LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OTULIN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OTULIN
  • 別名：
    AIPDS antibody; Deubiquitinating enzyme otulin antibody; F105B_HUMAN antibody; Fam105b antibody; Family with sequence similarity 105, member B antibody; FLJ34884 antibody; GUM antibody; OTU deubiquitinase with linear linkage specificity antibody; OTULIN antibody; Protein FAM105B antibody; Ubiquitin thioesterase Gumby antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin thioesterase otulin protein (1-287AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
  • 基因功能參考文獻：
    1. results establish a role for the linear Ubiquitin coat around cytosolic S. Typhimurium as the local NF-kappaB signalling platform and provide insights into the function of OTULIN in NF-kappaB activation during bacterial pathogenesis PMID: 28481361
    2. Biallelic hypomorphic mutations in OTULIN define otulipenia, an early-onset autoinflammatory disease. PMID: 27559085
    3. OTULIN is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis. PMID: 27523608
    4. cylindromatosis (CYLD) and OTULIN/Gumby/Fam105B, directly interact with the N-terminal PUB domain-containing region of HOIP. PMID: 24461064
    5. OTULIN restricts Met1-ubiquitin formation after immune receptor stimulation to prevent unwarranted proinflammatory signaling. PMID: 23806334
    6. reveal a previously unannotated human DUB, OTULIN (also known as FAM105B), which is exquisitely specific for Met1 linkages; data suggest that OTULIN regulates Met1-polyUb signaling. PMID: 23746843
    7. 2.4 A and 2.8 A crystal structures of gumby (Fam105b) in the presence of free ubiquitin and linear diubiquitin substrate, respectively PMID: 23708998

    顯示更多

    收起更多

  • 相關疾病：
    Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C65 family, Otulin subfamily
  • 數據庫鏈接：

    HGNC: 25118

    OMIM: 615712

    KEGG: hsa:90268

    STRING: 9606.ENSP00000284274

    UniGene: Hs.406335



主站蜘蛛池模板： 末成年毛片在线播放| 天堂网www中文在线| 2020精品自拍视频曝光| 婷婷五月综合国产激情| 久久午夜福利电影| 久久婷婷五月综合色一区二区| 欧美不卡一卡二卡三卡| 亚洲v国产v天堂a无码二区| 人妻熟妇乱又伦精品视频| 丰满爆乳一区二区三区| 亚洲精品无码mv在线观看| 国产无遮挡免费真人视频在线观看 | 亚洲熟妇久久国产精品| awww在线天堂bd资源在线| 天天躁日日躁狠狠躁视频2021| 加勒比一本heyzo高清视频| 国产精品亚洲综合久久系列| 久久成人伊人欧洲精品| 中国无码人妻丰满熟妇啪啪软件| 久久精品无码一区二区无码| 亚洲精品国产自在现线看| 欧美精品一国产成人综合久久| 最爽free性欧美人妖| 天天摸日日摸爽爽狠狠| 伊人色综合网久久天天| 丰满人妻精品国产99aⅴ | 国产福利自产拍| 农村老熟妇乱子伦视频| 精品久久久久久无码专区不卡| 午夜av亚洲一码二中文字幕青青| 在线观看免费视频网站a站| 国产精品美女一区二区三区| 久久精品国产一区二区三区| 亚洲在av极品无码| 久久久精品人妻一区二区三区蜜桃| 五级黄高潮片90分钟视频| 无码专区―va亚洲v专区在线 | 青青草原综合久久大伊人精品| 精品夜夜澡人妻无码av| 人妻丰满熟妇a无码区| 人人妻人人澡人人爽精品欧美 |