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  4. OTULIN Antibody, Biotin conjugated

OTULIN Antibody, Biotin conjugated

  • 中文名稱：
    OTULIN兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA853391LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OTULIN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OTULIN
  • 別名：
    AIPDS antibody; Deubiquitinating enzyme otulin antibody; F105B_HUMAN antibody; Fam105b antibody; Family with sequence similarity 105, member B antibody; FLJ34884 antibody; GUM antibody; OTU deubiquitinase with linear linkage specificity antibody; OTULIN antibody; Protein FAM105B antibody; Ubiquitin thioesterase Gumby antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin thioesterase otulin protein (1-287AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
  • 基因功能參考文獻：
    1. results establish a role for the linear Ubiquitin coat around cytosolic S. Typhimurium as the local NF-kappaB signalling platform and provide insights into the function of OTULIN in NF-kappaB activation during bacterial pathogenesis PMID: 28481361
    2. Biallelic hypomorphic mutations in OTULIN define otulipenia, an early-onset autoinflammatory disease. PMID: 27559085
    3. OTULIN is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis. PMID: 27523608
    4. cylindromatosis (CYLD) and OTULIN/Gumby/Fam105B, directly interact with the N-terminal PUB domain-containing region of HOIP. PMID: 24461064
    5. OTULIN restricts Met1-ubiquitin formation after immune receptor stimulation to prevent unwarranted proinflammatory signaling. PMID: 23806334
    6. reveal a previously unannotated human DUB, OTULIN (also known as FAM105B), which is exquisitely specific for Met1 linkages; data suggest that OTULIN regulates Met1-polyUb signaling. PMID: 23746843
    7. 2.4 A and 2.8 A crystal structures of gumby (Fam105b) in the presence of free ubiquitin and linear diubiquitin substrate, respectively PMID: 23708998

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  • 相關疾病：
    Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C65 family, Otulin subfamily
  • 數據庫鏈接：

    HGNC: 25118

    OMIM: 615712

    KEGG: hsa:90268

    STRING: 9606.ENSP00000284274

    UniGene: Hs.406335



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