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OTUD6B Antibody

  • 中文名稱：
    OTUD6B兔多克隆抗體
  • 貨號：
    CSB-PA847646LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: OTUD6B antibody at 4µg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: MDA-MB-231 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 34, 22 kDa
      Observed band size: 34 kDa
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA847646LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA847646LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OTUD6B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OTUD6B
  • 別名：
    CGI-77 antibody; DUBA-5 antibody; DUBA5 antibody; OTU domain containing protein 6B antibody; OTU domain-containing protein 6B antibody; OTU6B_HUMAN antibody; OTUD6B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Deubiquitinase OTUD6B protein (1-293AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，OTUD6B Antibody (CSB-PA847646LA01HU)，的標記方式是Non-conjugated。對于OTUD6B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA847646LB01HU OTUD6B Antibody, HRP conjugated ELISA
    FITC CSB-PA847646LC01HU OTUD6B Antibody, FITC conjugated
    Biotin CSB-PA847646LD01HU OTUD6B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation. May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation. May also play a role in proteasome assembly and function.; Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.
  • 基因功能參考文獻：
    1. The global OTUD6B expression level does not change significantly between nonneoplastic and malignant tissues, suggesting that modifications of splicing factors during the process of transformation are responsible for this isoform switch. PMID: 27864334
    2. OTUD6B encodes a deubiquitinating enzyme; study reports biallelic pathogenic variants in OTUD6B in 12 individuals from 6 families with intellectual disability syndrome associated with seizures & dysmorphic features; other features include developmental delay, microcephaly, absent speech, hypotonia, growth retardation, feeding difficulties, structural brain abnormalities, malformations of heart & musculoskeleton. PMID: 28343629
    3. down-regulation of Otud-6b expression after prolonged cytokine stimulation may be required for cell proliferation in B lymphocytes PMID: 21267069
  • 數據庫鏈接：

    HGNC: 24281

    OMIM: 612021

    KEGG: hsa:51633

    STRING: 9606.ENSP00000285420

    UniGene: Hs.30532



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