在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OSCAR Antibody, HRP conjugated

  • 中文名稱:
    OSCAR兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA811628OB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) OSCAR Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    OSCAR antibody; Osteoclast-associated immunoglobulin-like receptor antibody; Osteoclast-associated receptor antibody; hOSCAR antibody; Polymeric immunoglobulin receptor 3 antibody; PIgR-3 antibody; PIgR3 antibody; Poly-Ig receptor 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence from Human Osteoclast-associated immunoglobulin-like receptor protein (265-279AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
  • 基因功能參考文獻:
    1. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts PMID: 28555364
    2. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis. PMID: 26786702
    3. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1. PMID: 26552697
    4. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. PMID: 25716998
    5. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients. PMID: 23146195
    6. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA. PMID: 24448348
    7. Rotative stress in mouse cells results in increased levels of Oscar transcription. PMID: 22949349
    8. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion. PMID: 22985931
    9. OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 PMID: 22009730
    10. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
    11. This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases. PMID: 21172874
    12. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response. PMID: 15155468
    13. ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules PMID: 15650060
    14. Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor. PMID: 15905516
    15. Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women. PMID: 16007331
    16. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
    17. OSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses. PMID: 16493074
    18. OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation PMID: 18821671

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
  • 數據庫鏈接:

    HGNC: 29960

    OMIM: 606862

    KEGG: hsa:126014

    STRING: 9606.ENSP00000352671

    UniGene: Hs.347655



主站蜘蛛池模板: 伊伊综合在线视频无码| 亚洲国产日韩制服在线观看 | 免费国产污网站在线观看| 国产人妻久久精品二区三区老狼 | 国产亚洲tv在线观看| 在线观看免费视频网站a站| 久久无码字幕中文久久无码| 高清一区二区三区日本久| 激情综合亚洲色婷婷五月| 天堂www天堂在线资源| 粗大的内捧猛烈进出| 人妻无码一区二区不卡无码av| 欧洲熟妇色xxxxx视频| 日本无码一区二区三区不卡免费| 日本护士毛茸茸| 中文幕无线码中文字蜜桃 | 又大又粗又爽的少妇免费视频| 野花在线无码视频在线播放| 国产最大成人亚洲精品| 在线a亚洲视频播放在线观看| 女人被黑人躁得好爽视频| 东京热加勒比视频一区| 精品无码国产一区二区三区av| 国产最新进精品视频| 中文字幕无码日韩专区| 色综合久久婷婷五月| 黑人巨茎大战白人美女| 99在线精品免费视频九九视| 国产无套水多在线观看| 久久国产精品成人片免费| 337p人体粉嫩胞高清视频| 浪荡女天天不停挨cao日常视频| 成人无码a∨电影免费| 中文字幕丰满孑伦无码专区| 欧美 国产 日产 韩国 在线| 无码人妻精品一区二区三区久久| 999久久久国产精品| 国产av精国产传媒| 老司机性色福利精品视频| 国产精品无码久久久久久| 亚洲产国偷v产偷v自拍色戒|