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  4. OSBPL10 Antibody

OSBPL10 Antibody

  • 中文名稱：
    OSBPL10兔多克隆抗體
  • 貨號：
    CSB-PA017245GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    OSBPL10
  • 別名：
    FLJ20363 antibody; ORP-10 antibody; ORP10 antibody; OSB10_HUMAN antibody; OSBP related protein 10 antibody; OSBP-related protein 10 antibody; OSBP9 antibody; OSBPL 10 antibody; OSBPL10 antibody; Oxysterol binding protein like 10 antibody; Oxysterol binding protein related protein 10 antibody; Oxysterol-binding protein-related protein 10 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human OSBPL10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.
  • 基因功能參考文獻：
    1. Data indicate that the apoB-100 secretion phenotype is replicated in HepG2 cells transduced with the ORP10 shRNA lentiviruses. PMID: 22906437
    2. Single-nucleotide polymorphisms in OSBPL10 is associated with peripheral arterial disease. PMID: 20610895
    3. Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals to hyper-LDL cholesterolemia. PMID: 20224571
    4. Analysis of variants in three genes encoding OSBP homologues in families with familial low high-density lipoprotein levels or familial combined hyperlipidemia revealed linkage of OSBPL10 single-nucleotide polymorphisms with high triglyceride trait. PMID: 19554302
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    OSBP family
  • 數據庫鏈接：

    HGNC: 16395

    OMIM: 606738

    KEGG: hsa:114884

    STRING: 9606.ENSP00000379804

    UniGene: Hs.150122



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