在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OS9 Antibody, FITC conjugated

  • 中文名稱:
    OS9兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA613402LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) OS9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Amplified in osteosarcoma 9 antibody; amplified in osteosarcoma antibody; ERLEC2 antibody; OS-9 antibody; Os9 antibody; OS9_HUMAN antibody; Osteosarcoma amplified 9 endoplasmic reticulum lectin antibody; Protein OS-9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein OS-9 protein (232-413AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.
  • 基因功能參考文獻:
    1. The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. PMID: 28419469
    2. OS-9 up-regulates occludin and claudin-1 by activating the MAP kinase (MAPK) pathway, and thus protects the epithelial barrier function of Caco-2 monolayer under hypoxia condition. PMID: 25999789
    3. EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog PMID: 24910992
    4. Unique regions mediate the interaction between OS-9 and GRP94. PMID: 24899641
    5. It delivers mutant neuroserpin to ERAD by recognition of glycan side chains and provide the first in vivo proof of involvement of ERAD in degradation of mutant neuroserpin. PMID: 24795221
    6. long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha in pancreatic ductal adenocarcinoma. PMID: 25314054
    7. Data indicate that the interaction of OS-9 and XTP3-B with CD147(CG) was inhibited by mutations to conserved residues in their lectin domains. PMID: 23097496
    8. OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization PMID: 21559462
    9. It regulates endoplasmic reticulum-associated degradation. (review) PMID: 21404621
    10. The OS-9 specifically recognizes Manalpha1,6Manalpha1,6Man residues on the processed C-arm through the continuous double tryptophan (WW) motif. PMID: 21172656
    11. The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation PMID: 19914915
    12. Identification of a peptide, resulting from a point mutation in gene OS-9, recognized by cytolytic T lymphocytes on a human melanoma. PMID: 12747754
    13. OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation. PMID: 17932042
    14. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD PMID: 18264092
    15. Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum inhibit secretion of misfolded protein conformers and enhancing their disposal PMID: 18417469
    16. OS9 is critically involved in the modulation of ER-to-Golgi transport of DC-STAMP in response to TLR triggering, suggesting a novel role for OS9 in myeloid differentiation and cell fusion. PMID: 18952287
    17. OS-9 recognises terminally misfolded proteins via polypeptide-based rather than glycan-based signals, but is only required for transferring those bearing N-glycans to the ubiquitination machinery. PMID: 19084021
    18. model for mannose trimming and the requirement for OS-9 lectin activity in glycoprotein ERAD in which N-glycans lacking the terminal mannose from the C branch are recognized by OS-9 and targeted for degradation PMID: 19346256

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 蛋白家族:
    OS-9 family
  • 組織特異性:
    Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
  • 數據庫鏈接:

    HGNC: 16994

    OMIM: 609677

    KEGG: hsa:10956

    STRING: 9606.ENSP00000318165

    UniGene: Hs.527861



主站蜘蛛池模板: 欧美xxxx欧美精品| 亚洲色老汉av无码专区最| 护士av无码在线观看| 精品国产一区二区三区免费| 性生交大片免费看| 国产免费看又黄又大又污的胸| 欧美xxxxx在线观看| 欧美精品一区二区三区在线| 俄罗斯丰满熟妇hd| 免费女人裸体视频无遮挡免费网站| 2019精品国自产拍在线不卡| 国产一在线精品一区在线观看 | 亚洲欧美日韩综合俺去了| 亚洲狠狠婷婷综合久久| 最近中文2019字幕第二页| 久久精品国产男包| 亚洲人成人77777网站| 国产精品久久..4399| 98视频精品全部国产| 国产欧美日韩亚洲18禁在线| 精品无码人妻一区二区三区| 久久777国产线看观看精品 | 国产97在线 | 日韩| 中字幕视频在线永久在线| 中文国产成人精品久久app| 国产手机在线αⅴ片无码观看| 日韩精品一区二区三区在线观看l| 国产精品va在线观看h| 无码人妻精品中文字幕免费东京热 | 亚洲日韩国产精品无码av| 国产农村老太xxxxhdxx| 少妇性l交大片毛多| 亚洲人成无码网www动漫| 亚洲高清毛片一区二区| 蜜臀aⅴ国产精品久久久国产老师 日韩一区二区三区精品 | 亚洲熟妇av午夜无码不卡| 久久青青草免费线频观| 级r片内射在线视频播放| 色v99在线影院| 国产草莓视频无码a在线观看 | 色丁香婷婷综合久久|