在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ORC6 Antibody

  • 中文名稱:
    ORC6兔多克隆抗體
  • 貨號:
    CSB-PA017236GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ORC 6 antibody; Orc6 antibody; ORC6_HUMAN antibody; ORC6L antibody; Origin recognition complex subunit 6 antibody; origin recognition complex subunit 6 homolog like antibody; origin recognition complex subunit 6 homolog like (yeast) antibody; origin recognition complex subunit 6 like (yeast) antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ORC6L
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
  • 基因功能參考文獻:
    1. The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene. PMID: 28186598
    2. The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation. PMID: 25691413
    3. our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions PMID: 24137536
    4. findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process. PMID: 21461783
    5. Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. PMID: 21502537
    6. results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis PMID: 12169736
    7. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
    8. Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin PMID: 19112505
    9. In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans. PMID: 19541634
    10. Functional studies of the Drosophila homolog PMID: 11593009
    11. Functional studies of the yeast homolog PMID: 8266075

    顯示更多

    收起更多

  • 相關疾病:
    Meier-Gorlin syndrome 3 (MGORS3)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ORC6 family
  • 數據庫鏈接:

    HGNC: 17151

    OMIM: 607213

    KEGG: hsa:23594

    STRING: 9606.ENSP00000219097

    UniGene: Hs.49760



主站蜘蛛池模板: 久久久久久久久久久久久9999 | 女人裸露免费视频无遮挡网站| 99久久精品国产一区二区| 人妻少妇熟女javhd| 国产女人和拘做受视频免费| 无码任你躁久久久久久久| 狠狠色噜噜狠狠狠狠色综合久av | 亚洲色大成网站久久久| 久久这里精品国产99丫e6| 久久久这里只有免费精品| 精品国产丝袜自在线拍国语| 亚洲乱码伦av| 小说区 图片区色 综合区| 亚洲国产午夜精品理论片| 国产乱人伦偷精品视频免| 欧美日韩国产综合新一区| 亚洲精品一区二区久| 成人无遮羞视频在线观看| 欧美性猛交xxxxx按摩欧美| 久久久久成人精品无码中文字幕| 精品黑人一区二区三区久久| 久久国产美女精品久久| 亚洲高清乱码午夜电影网制服| 曰批免费视频播放免费| 国产成人小视频| 亚洲欧美综合国产精品二区| 国产av一二三无码影片| 高级会所人妻互换94部分| 亚洲熟妇无码av另类vr影视| 午夜亚洲影院在线观看| 精品人妻无码一区二区色欲产成人| 女人被弄到高潮的免费视频| 国精品午夜福利视频不卡| 免费人成又黄又爽的视频 | 精品欧美小视频在线观看| 久久精品国产69国产精品亚洲| 水蜜桃av无码| 人妻少妇精品无码专区芭乐视网| 婷婷综合久久中文字幕| 久久久久人妻一区精品色欧美| 国产老熟女老女人老人|