在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ORC4 Antibody

  • 中文名稱:
    ORC4兔多克隆抗體
  • 貨號:
    CSB-PA017234GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    cognition complex; subunit 4; S. cerevisiae; homolog of antibody; FLJ46668 antibody; HSORC4 antibody; ORC 4 antibody; ORC 4L antibody; ORC 4P antibody; ORC4 antibody; ORC4_HUMAN antibody; ORC4L antibody; ORC4L protein antibody; ORC4P antibody; Origin recognition complex subunit 4 (yeast homolog) like antibody; Origin recognition complex subunit 4 antibody; Origin recognition complex subunit 4 like (yeast) antibody; Origin recognition complex subunit 4 like antibody; origin recognition complex; subunit 4 homolog antibody; Origin recognition complex; subunit 4; S. cerevisiae; homolog-like antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ORC4L
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
  • 基因功能參考文獻:
    1. Since the site of one of the missense mutations in the human ORC4 alleles is conserved between humans and yeast, we sought to determine in what way this single amino acid change affects the process of chromosome replication, by introducing the comparable mutation into yeast (orc4Y232C). PMID: 29036220
    2. HsOrc4 could have a fundamental function in the process of initiation of replication by remodeling the structure of origin of replication using the energy of supercoiled DNA. PMID: 26124052
    3. compared with homozygous missense mutations, compound heterozygous mutations appeared to have a more severe effect on phenotype, causing more severe growth retardation in ORC4 PMID: 22333897
    4. identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome PMID: 21358631
    5. DNA binding activity of HsOrc4 depends on length and structure of DNA with triplex being the protein's preferred binding target. PMID: 19690980
    6. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
    7. describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and 1 with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene PMID: 20010161
    8. Biochemical characterization of the mouse homolog PMID: 10460412

    顯示更多

    收起更多

  • 相關疾病:
    Meier-Gorlin syndrome 2 (MGORS2)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ORC4 family
  • 數據庫鏈接:

    HGNC: 8490

    OMIM: 603056

    KEGG: hsa:5000

    STRING: 9606.ENSP00000264169

    UniGene: Hs.558364



主站蜘蛛池模板: 国产大陆亚洲精品国产| 成人亚欧欧美激情在线观看| 99久久无色码中文字幕人妻| 久久久97丨国产人妻熟女| 最新高清无码专区| 蜜桃一区二区三区| 国产精品尹人在线观看| 免费看成人毛片无码视频| 国产成人a视频高清在线观看| 欧美老熟妇又粗又大| 亚洲一区无码中文字幕| 国产av天堂亚洲国产av下载| 免费国偷自产拍精品视频 | 奇米777四色影视在线看| 国产亚洲精品久久久久久久久动漫 | 欧美真人性做爰全过程| 97久久香蕉国产线看观看| 精品国产乱码久久久久乱码| 日产精品卡二卡三卡四卡区满十八 | 人妻av中文系列| 欧美xxxxx高潮喷水麻豆| 亚洲国产成人超a在线播放| 午夜福利精品导航凹凸| 精品国产美女福到在线不卡| 狠狠cao2020高清视频| 92午夜福利少妇系列| 又色又爽又黄18禁美女裸身无遮挡| 欧美国产日韩a在线视频| 77777亚洲午夜久久多喷| 黄瓜视频在线观看网址| 久久亚洲私人国产精品| 久久亚洲国产精品亚洲老地址| 国产男女免费完整视频网页| 激情内射日本一区二区三区| 少妇午夜福利一区二区| 中文字幕无码中文字幕有码a | 中文字幕无码人妻aaa片| 国产区又黄又硬高潮的视频| 久久这里有精品国产电影网| 高潮毛片又色又爽免费| 欧美黑人异族videos|