在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OPHN1 Antibody

  • 中文名稱:
    OPHN1兔多克隆抗體
  • 貨號:
    CSB-PA016348GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    OPHN1
  • 別名:
    OPHN1 antibody; Oligophrenin-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human OPHN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.
  • 基因功能參考文獻:
    1. Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment PMID: 27146843
    2. Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets. PMID: 27742778
    3. we reported on the first male patient carrying an OPHN1 mutation with IQ score within the normal limits. This observation expands the phenotypic spectrum of OPHN1 mutations. PMID: 27390894
    4. A neuronal stem cell-based model for the treatment of OPHN1 syndrome and other neurological disorders due to ROCK dysfunction. PMID: 27160703
    5. results suggest that oligophrenin-1 is involved in tumor progression in prostate cancer PMID: 25170626
    6. This is the first description of an in-frame deletion within the BAR domain of OPHN1 and could provide new insights into the role of this domain in relation to brain and cognitive development or function. PMID: 24105372
    7. Our results demonstrate that multiple post-transcriptional events occur on OPHN1, a gene playing an important role in brain function and development. PMID: 24637888
    8. In response to GPVI stimulation, OPHN1 becomes phosphorylated at Tyr370 and plays a role in the formation of filopodia during platelet spreading on collagen. PMID: 23619296
    9. This mutation determines the production of a mutant oligophrenin 1 protein with 16 extra amino acids inserted in-frame in the N-terminal BAR (Bin1/amphiphysin/Rvs167) domain. (oligophrenin 1 protein ) PMID: 21796728
    10. Data suggest that OPHN1 defect may be an important contributory factor to XLMR. PMID: 20528889
    11. The OPHN1 gene plays a role during the development of the human cerebellum. PMID: 12807966
    12. Found in glial cells forming myelin sheaths in the vagus nerve, sciatic nerve and dorsal roots of guinea-pig, rat and human, in chromaffin cells of the adrenal medulla, and in chromaffin cells associated with sympathetic ganglia. PMID: 15026118
    13. Oligophrenin 1 mutations were found in 12% (2/17) of individuals with mental retardatin and known cerebellar anomalies and in 1% (2/196) of the X-linked mental retardation group. PMID: 16221952
    14. Disruption of the OPHN1 gene on Xq12 is associated with mental retardation and tall stature PMID: 17845870
    15. oligophrenin 1 gene (OPHN1) is an Rho-GTPase-activating protein involved in the regulation of the G-protein cycle required for dendritic spine morphogenesis PMID: 18261018

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, X-linked, syndromic, OPHN1-related (MRXSO)
  • 亞細胞定位:
    Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm.
  • 組織特異性:
    Expressed in brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8148

    OMIM: 300127

    KEGG: hsa:4983

    STRING: 9606.ENSP00000347710

    UniGene: Hs.128824



主站蜘蛛池模板: 国产精品色无码av在线观看| 热re99久久精品国99热| 国产成a人片在线观看视频下载| 无码国模国产在线观看免费| 亚洲超清无码制服丝袜无广告| 十八禁av无码免费网站| 国产欧美一区二区精品性色| av无码一区二区大桥久未| 国语自产拍在线视频中文| 亚洲综合久久成人a片| 亚洲日韩aⅴ在线视频| 无码人妻一区二区三区一| 中文字幕av无码不卡免费| 婷婷网色偷偷亚洲男人甘肃| 俺去俺来也在线www色官网| 四虎影视国产精品久久| 少妇性荡欲视频| 军人粗大的内捧猛烈进出视频| 欧美内射rape视频| 国产又色又爽又黄的在线观看视频| 精品久久久久久亚洲中文字幕| 午夜男女xx00视频福利| 人妻中文字幕av无码专区| 婷婷五月俺也去人妻| 国产av天堂亚洲国产av下载| 亚洲日韩av在线观看| 波多野42部无码喷潮在线| 国产精品久久久久9999不卡 | 人人妻人人澡人人爽精品欧美| 免费体验区试看120秒| 亚洲暴爽av天天爽日日碰| 久久99er精品国产首页| 国产精品综合色区在线观看| 精品人妻一区二区三区四区在线 | 国产成人综合久久精品推下载| 日本少妇人妻xxxxx18| 影音先锋男人av鲁色资源网| 少妇精品无码一区二区三区| 国产又黄又潮娇喘视频在线观看| 国产乱人伦偷精精品视频| 久久这里只精品国产免费10|