在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OMA1 Antibody

  • 中文名稱:
    OMA1兔多克隆抗體
  • 貨號:
    CSB-PA016332GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    OMA1; MPRP1; Metalloendopeptidase OMA1, mitochondrial; Metalloprotease-related protein 1; MPRP-1; Overlapping with the m-AAA protease 1 homolog
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human OMA1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes.
  • 基因功能參考文獻:
    1. differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults. PMID: 26923599
    2. Cleavage of the inner membrane fusion factor L-OPA1 is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential. PMID: 24634514
    3. OMA1 is cleaved to a short form (S-OMA1) by itself upon mitochondrial membrane depolarization; S-OMA1 is degraded quickly but could be stabilized by CCCP treatment or Prohibitin knockdown in cells. PMID: 24719224
    4. These findings demonstrate that (a) p53 and Oma1 mediate L-Opa1 processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics PMID: 25112877
    5. OMA1 controls OPA1 cleavage and function. PMID: 20038677
    6. These results provide evidence for different substrate specificities of m-AAA proteases composed of different subunits and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin-like GTPases in mitochondria. PMID: 17615298

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族:
    Peptidase M48 family
  • 組織特異性:
    Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver.
  • 數據庫鏈接:

    HGNC: 29661

    KEGG: hsa:115209

    STRING: 9606.ENSP00000360270

    UniGene: Hs.425769



主站蜘蛛池模板: 欧美性xxxxx极品少妇| 亚洲熟妇av一区二区三区漫画| 成人免费看片又大又黄| 97国产精品人妻无码久久久| 国产日产亚洲系列最新美使用方法 | 成人爱做日本视频免费| 狠狠噜天天噜日日噜色综合| 亚洲aⅴ无码专区在线观看q| 日韩吃奶摸下aa片免费观看| 欧美日韩午夜群交多人轮换| 丰满人妻一区二区三区无码av| 国产乱人伦偷精品视频免| 青青草原精品资源站久久| 成 人免费va视频| 国产区精品系列在线观看| 国内精品久久久久久无码| 亚洲欧美成人一区二区在线电影| 色情一区二区三区免费看| 亚洲国色天香卡2卡3卡4| 天堂网www在线资源最新版| 天堂在线.www天堂在线资源| 国产超碰人人做人人爱ⅴa| 男女野外做爰全过程69影院| 97久久超碰精品视觉盛宴| 国产又爽又黄又无遮挡的激情视频 | 男女猛烈xx00免费视频试看| 99久久精品无码一区二区毛片| 春药高潮抽搐流白浆在线观看| 男女下面一进一出无遮挡| 天天做天天摸天天爽天天爱| 成年男人裸j照无遮挡无码| 爆乳高潮喷水无码正在播放 | 日日天干夜夜狠狠爱| 亚洲中文字幕无码av| 久久久久久久波多野结衣高潮| 亚洲国产欧美在线人成app | 51被公侵犯玩弄漂亮人妻 | 国产乱码一区二区三区| 欧美亚洲精品中文字幕乱码| 久久毛片免费看一区二区三区| 久久精品国产网红主播|