在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ODC1 Antibody

  • 中文名稱:
    ODC1兔多克隆抗體
  • 貨號:
    CSB-PA818178
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA818178(ODC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA818178(ODC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    ODC1
  • 別名:
    DCOR_HUMAN antibody; Dodc1 antibody; Odc 1 antibody; ODC antibody; Odc1 antibody; ODC2 antibody; Ornithine decarboxylase 1 antibody; Ornithine decarboxylase 2 antibody; Ornithine decarboxylase antibody; Ornithine decarboxylase structural 1 antibody; RNODC antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ODC1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
  • 基因功能參考文獻:
    1. Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT expression, and the Akt1-mediated pathway. PMID: 28157137
    2. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN). PMID: 27770613
    3. Findings suggest that targeting ornithine decarboxylase 1 (ODC1) could be an attractive option for molecular therapy of hepatocellular carcinoma (HCC). PMID: 27592554
    4. Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose. PMID: 27555600
    5. mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 and ornithine decarboxylase PMID: 26172301
    6. We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation. PMID: 26093909
    7. Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content. PMID: 26178413
    8. High ODC expression is associated with Medulloblastoma. PMID: 26460945
    9. Data suggest that down-regulation of ODC (using siRNA or pharmacologic inhibitor) in bone marrow-derived mesenchymal stem cells results in reduced intracellular polyamines (putrescine, spermidine, and spermine) and enhanced osteogenesis. PMID: 26140984
    10. tumor ornithine decarboxylase level heterogeneity increased with increasing tumor malignancy PMID: 17582600
    11. The results suggested that the ODC gene might act as a prognostic factor for breast cancer and it could be a promising therapeutic target. PMID: 18330478
    12. BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue PMID: 24386364
    13. Akt activation by ODC+COX-2 over-expression. PMID: 24260338
    14. Authors identified SPR as a novel regulator of ODC enzyme activity and, based on clinical evidence, present a model in which SPR drives ODC-mediated malignant progression in neuroblastoma. PMID: 24096079
    15. ODC overexpression suppresses the expression of tumstatin, which may provide fundamental evidence for the combination of anti-angiogenic therapy and conventional therapy for cancer treatment. PMID: 24002681
    16. The results of this study suggest that specific genetic variants in a subset of glutamatergic (GRIN2B) and polyaminergic (ODC1) neurosystem genes may be of importance in certain suicidal subjects. PMID: 22850629
    17. There are five conserved residues in ODC. PMID: 23872168
    18. Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology. PMID: 23917584
    19. Overexpression of antizyme (AZ), an ornithine decarboxylase (ODC) inhibitory protein, suppressed ERalpha expression, suggesting that ODC plays an important role in regulation of ERalpha expression. PMID: 22976807
    20. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. PMID: 22730407
    21. Variants of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention. PMID: 21930798
    22. the mechanism of formation of the internal aldimine, a common intermediate to most pyridoxal 5'-phosphate (PLP)-dependent enzymes PMID: 21854048
    23. There was no significant association between ODC G316A and risk of colorectal cancer for either heterozygotes or rare allele homozygotes. PMID: 20456464
    24. Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. PMID: 21454364
    25. Gingival ornithine decarboxylase levels were higher in the gingivitis group compared to the periodontitis and healthy groups at baseline. PMID: 20831369
    26. Overexpression of ODC suppresses thapsigargin-induced apoptosis, blocks caspase-4 activation and PERK phosphorylation,and attenuates CHOP expression. It inhibits Bak increase and maintains Bcl-2 expression, blocking the intrinsic pathway of apoptosis. PMID: 20814750
    27. Ornithine decarboxylase induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation in human oral cancer cell line. PMID: 20838441
    28. ODC activity, which AZIN2 is assumed to regulate, is strongly associated with cell growth and transformation. PMID: 19832840
    29. Low Ornithine decarboxylase mRNA expression is associated with more aggressive non-small-cell lung cancer. PMID: 20199977
    30. Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression. PMID: 11830503
    31. ODC activity reflects aggressive growth and malignization in meningiomas. PMID: 15015770
    32. Data show that expressing whole proteins, protein domains, or peptide ligands fused to the N terminus of ornithine decarboxylase promotes proteasome-dependent degradation of these chimeric fusion proteins and their interacting cellular target proteins. PMID: 16219697
    33. review of key factors that contribute to the regulation of ornithine decarboxylase levels, which can occur at the levels of transcription, translation, and protein turnover [review] PMID: 16459331
    34. findings show that antibody-bound amyloid precursor protein induces expression of ornithine decarboxylase PMID: 16469300
    35. Data suggest that prolaction-mediated induction of ornithine decarboxylase activity enhances expression of Bcl-2 strongly enough to bring about prolactin's anti-apoptotic function. PMID: 16520895
    36. This is the first report showing the existence of a causal relationship between ornithine decarboxylase expression, Erk and p38 MAP kinase activation, and MMP-2 expression. PMID: 17088079
    37. no association observed between the ODC ploymorphism and H. pylori seropositivity; results did not support the hypothesis that the different genetic traits in the ODC-polyamine pathway are associated with susceptibility to persistent H. pylori infection PMID: 17378176
    38. The expression of ornithine decarboxylase is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. PMID: 17569126
    39. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. PMID: 17957960
    40. Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells. PMID: 18548481
    41. Elevated ODC1 (independent of MYCN amplification) was associated with reduced survival in a large independent neuroblastoma cohort. PMID: 19047152
    42. sporadic breast cancer, the presence of at least one A allele in ornithine decarboxylase is protective against the disease. PMID: 19225907
    43. The ODC1 SNP may be protective for colon adenoma recurrence and detrimental for survival after colon cancer diagnosis. PMID: 19789310

    顯示更多

    收起更多

  • 蛋白家族:
    Orn/Lys/Arg decarboxylase class-II family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8109

    OMIM: 165640

    KEGG: hsa:4953

    STRING: 9606.ENSP00000234111

    UniGene: Hs.467701



主站蜘蛛池模板: 国产精品久久婷婷六月丁香| 国产成人无码区免费网站| 亚洲成av人综合在线观看| 国产精品99久久精品| 人人澡人人曰人人摸看| 亚洲成av人片在线观看下载| 成人免费视频一区二区三区| 色爱情人网站| 一本一道久久综合久久| 亚洲国产精品ⅴa在线播放| 国产女人高潮叫床视频| 欧美 国产 日产 韩国 在线| 中文字幕av无码人妻| 日日噜狠狠噜天天噜av| 国产麻豆精品一区| 思思99re6国产在线播放| 国产公开久久人人97超碰| 日本一区二区三区免费高清| 日本大乳高潮视频在线观看| 色婷婷我要去我去也| 亚洲精品久久久久中文字幕m男| 凹凸在线无码免费视频| 狠狠干狠狠爱| 2019亚洲午夜无码天堂| 亚洲欧洲精品成人久久曰影片| 成人毛片无码一区二区三区| 免费国产h视频在线观看| 国产精品毛片更新无码| 国产成人精品久久| 精品无码一区二区三区电影| 日本欧美亚洲中文在线观看| 国产又黄又爽又色的免费视频 | av天堂亚洲区无码先锋影音| 亚洲欧美中文日韩v在线观看| 无码精品久久一区二区三区| 天堂√在线中文最新版| 99精品国产成人一区二区| 西西人体大胆午夜啪啪| 国精品人妻无码一区二区三区性色| 国产在线视频一区二区三区| 日韩一区二区三区精品|