在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OAT Antibody

  • 中文名稱:
    OAT兔多克隆抗體
  • 貨號:
    CSB-PA914838
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from K562/COLO205 cells, using OAT antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) OAT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    OAT
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Internal of Human OAT.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
  • 基因功能參考文獻:
    1. OAT Val332-to-Met substitution identified in pyridoxine-responsive gyrate atrophy patients does not significantly affect the spectroscopic and kinetic properties of OAT, but during catalysis it makes the protein prone to convert into the apo-form, which undergoes unfolding and aggregation under physiological conditions. PMID: 30251682
    2. identified Arg217 as an important hot-spot at the dimer-dimer interface of hOAT and demonstrated that the artificial dimeric variant R217A exhibits spectroscopic properties, Tm values and catalytic features similar to those of the tetrameric species. This finding indicates that the catalytic unit of hOAT is the dimer. PMID: 28345116
    3. Sequencing of the gene for ornithine aminotransferase reveals a homozygous mutation in our patient (base exchange c.498C>A in Exon 4). PMID: 26259030
    4. Neurogenesis is inhibited by X-OAT during Xenopus embryonic development, but it is essential for Xenopus embryonic development. The Arg 180 and Leu 402 are crucial for these effects of the OAT molecule in development. PMID: 25783604
    5. Our report describes the first case of gyrate atrophy in the Korean population diagnosed by OAT gene analysis and treated with vitamin B6 dietary supplementation. PMID: 24082780
    6. We identified a novel frameshift mutation (p.K169DfsX10) in the OAT gene. While an early arginine-restricted dietary treatment suppressed the fundus changes PMID: 24429551
    7. Data suggest that other factors besides the specific ornithine aminotransferase (OAT) genotype modulate atrophy of choroid and retina (GA) phenotype in patients. PMID: 23076989
    8. OAT was a highly homologous and stable protein located in the mitochondria. PMID: 22989455
    9. Molecular analysis revealed a new deletion c.532_536delTGGGG (p.Trp178X) and a known mutation c.897C>G (p.Tyr299X) in the OAT gene. PMID: 22674428
    10. Fundus autofluorescence imaging can reveal the extent of neurosensory dysfunction in gyrate atrophy patients. PMID: 22182799
    11. analysis of ornithine aminotransferase substrate specificity PMID: 16096275

    顯示更多

    收起更多

  • 相關疾病:
    Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Class-III pyridoxal-phosphate-dependent aminotransferase family
  • 數據庫鏈接:

    HGNC: 8091

    OMIM: 258870

    KEGG: hsa:4942

    STRING: 9606.ENSP00000357838

    UniGene: Hs.523332



主站蜘蛛池模板: 草草影院发布页| 久久久久久无码av成人影院| 国产午夜福利精品久久2021| 久久久久久免费毛片精品| 亚洲国产成人精品青青草原| 婷婷五月综合丁香在线| 在线看免费无码av天堂的| 久久精品国产精品亚洲艾草网 | 欧洲女人牲交性开放视频| 国产精品亚洲а∨无码播放不卡| 九九精品无码专区免费| 亚洲熟熟妇xxxx| 日韩去日本高清在线| 无码纯肉动漫在线观看| 日韩精品一区二区三区| 国产爆乳无码视频在线观看3 | 国产午夜福利在线播放87| 国产在线不卡精品网站| 夜夜高潮夜夜爽高清完整版1| 亚洲动漫精品无码av天堂| 国产 日韩 欧美 视频 制服| 人人妻人人澡人人爽精品欧美 | av区无码字幕中文色| 98久9在线 | 免费| 狠狠色噜噜狠狠狠8888米奇| 亚洲中文字幕丝祙制服| 人人妻人人妻人人人人妻人人| 亚洲 欧美 激情 小说 另类| 中文字幕精品一区二区精品| 变态另类先锋影音| 国产精品厕所| 国产精品ⅴ无码大片在线看| 亚洲电影天堂av2017| 亚洲精品少妇一区二区| 无码国内精品人妻少妇蜜桃视频| 亚洲欧美精品suv| 国产无遮挡又黄又爽动态图| 国产成人无码一二三区视频| 大战熟女丰满人妻av| 久久久噜噜噜久久熟女色| 欧美午夜刺激影院|