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  4. OAS3 Antibody, FITC conjugated

OAS3 Antibody, FITC conjugated

  • 中文名稱：
    OAS3兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA897591LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OAS3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    (2-5'')oligo(A) synthase 3 antibody; 2 5' oligo(A) synthetase 3 antibody; 2 5'LIGO antibody; 2 5A synthetase 3 antibody; 2''-5''-oligoadenylate synthase 3 antibody; 2-5A synthase 3 antibody; MGC133260 antibody; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa antibody; OAS3 antibody; OAS3_HUMAN antibody; p100 antibody; p100 OAS antibody; p100OAS antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human 2'-5'-oligoadenylate synthase 3 protein (424-565AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
  • 基因功能參考文獻：
    1. Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. PMID: 28418037
    2. Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic hepatitis B infection in Chinese Han population. PMID: 29582521
    3. The study findings suggest that the OAS3 rs1859330 G/A genetic polymorphism is associated with the severity of enterovirus 71 (EV71) infection, and that the A allele is a risk factor for the development of severe EV71 infection. PMID: 28444539
    4. Here we report, to our knowledge, the first analysis of nuclear signal import in the pseudo enzymatic domain DI of human OAS3 PMID: 27379722
    5. OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation. PMID: 26858407
    6. By means of an allelic association study of a cohort of 740 patients with dengue, the authors found a protective effect of OAS3_R381 against shock. PMID: 26063222
    7. Common variation at 12q24.13 (OAS3 intron) influences chronic lymphocytic leukemia risk. PMID: 25363670
    8. The combined high affinity for double-stranded RNA and the capability to produce 2'-5'-linked oligoadenylates of sufficient length to activate RNase L suggests that OAS3 is a potent activator of RNase L. PMID: 25275129
    9. OAS are interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation [review] PMID: 17408844

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    2-5A synthase family
  • 組織特異性：
    Present at high level in placenta trophoblast.
  • 數據庫鏈接：

    HGNC: 8088

    OMIM: 603351

    KEGG: hsa:4940

    STRING: 9606.ENSP00000228928

    UniGene: Hs.528634



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