在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

OAS3 Antibody, FITC conjugated

  • 中文名稱:
    OAS3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA897591LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) OAS3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    (2-5'')oligo(A) synthase 3 antibody; 2 5' oligo(A) synthetase 3 antibody; 2 5'LIGO antibody; 2 5A synthetase 3 antibody; 2''-5''-oligoadenylate synthase 3 antibody; 2-5A synthase 3 antibody; MGC133260 antibody; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa antibody; OAS3 antibody; OAS3_HUMAN antibody; p100 antibody; p100 OAS antibody; p100OAS antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 2'-5'-oligoadenylate synthase 3 protein (424-565AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
  • 基因功能參考文獻:
    1. Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. PMID: 28418037
    2. Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic hepatitis B infection in Chinese Han population. PMID: 29582521
    3. The study findings suggest that the OAS3 rs1859330 G/A genetic polymorphism is associated with the severity of enterovirus 71 (EV71) infection, and that the A allele is a risk factor for the development of severe EV71 infection. PMID: 28444539
    4. Here we report, to our knowledge, the first analysis of nuclear signal import in the pseudo enzymatic domain DI of human OAS3 PMID: 27379722
    5. OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation. PMID: 26858407
    6. By means of an allelic association study of a cohort of 740 patients with dengue, the authors found a protective effect of OAS3_R381 against shock. PMID: 26063222
    7. Common variation at 12q24.13 (OAS3 intron) influences chronic lymphocytic leukemia risk. PMID: 25363670
    8. The combined high affinity for double-stranded RNA and the capability to produce 2'-5'-linked oligoadenylates of sufficient length to activate RNase L suggests that OAS3 is a potent activator of RNase L. PMID: 25275129
    9. OAS are interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation [review] PMID: 17408844

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    2-5A synthase family
  • 組織特異性:
    Present at high level in placenta trophoblast.
  • 數據庫鏈接:

    HGNC: 8088

    OMIM: 603351

    KEGG: hsa:4940

    STRING: 9606.ENSP00000228928

    UniGene: Hs.528634



主站蜘蛛池模板: 色猫咪av在线观看| 四虎国产精品免费久久久| 国产女主播白浆在线观看| 中国性少妇内射xxxx狠干| 精品四虎国产在免费观看| 又嫩又硬又黄又爽的视频| 国产一区二区三区乱码在线观看| 色一情一区二区三区四区| 婷婷六月丁香缴 清| 亚洲精品久久66国产高清| 精品久久久无码中文字幕天天 | 色哟哟国产精品免费观看| 亚洲制服丝袜av一区二区三区| 国产沙发午睡系列999| 玖玖资源站无码专区| 国产精品丝袜黑色高跟鞋| 日本强伦姧人妻一区二区| 美女人妻激情乱人伦| 国模雨珍浓密毛大尺度150p| 少妇私密会所按摩到高潮呻吟| 亚洲欧美综合区丁香五月小说| 国产一卡三卡四卡无卡精品| 四虎国产精品永久地址49| 无码国产成人午夜电影在线观看| 国产精品av免费观看| 亚洲欧美日本久久综合网站| 亚洲午夜成人精品无码| 国内大量偷窥精品视频| 国内自产少妇自拍区免费| 美日欧激情av大片免费观看| 欧美日韩不卡合集视频| 免费大黄网站在线观| 国产亚洲精品久久久久9999| 深爱婷婷国产在线精品av| 亚洲一卡二卡三卡四卡| 亚洲一区在线日韩在线秋葵| 日本亚州视频在线八a| 四虎成人精品在永久免费| 久久久久国精品产熟女久色| 国产最新av在线播放不卡| 无码人妻人妻经典|