在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NXF1 Antibody, Biotin conjugated

  • 中文名稱:
    NXF1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA016218LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NXF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NXF1
  • 別名:
    DKFZp667O0311 antibody; DmNXF1 antibody; MEX67 antibody; MEX67, yeast, homolog of antibody; Mex67p antibody; mRNA export factor TAP antibody; Mvb1 antibody; Nuclear RNA export factor 1 antibody; Nuclear RNA export factor 1 homolog (S. cerevisiae) antibody; nxf 1 antibody; NXF1 antibody; NXF1_HUMAN antibody; Protein small bristles antibody; Sbr antibody; TAP antibody; Tip associating protein antibody; Tip-associated protein antibody; Tip-associating protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Nuclear RNA export factor 1 protein (1-130AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
  • 基因功能參考文獻:
    1. Gain or loss-of-function experiments revealed NXF1 selectively regulates TLR7-driven IRF5 transcriptional activity, suggesting a new role for NXF1 in the IRF5 signaling pathway. PMID: 28578407
    2. repeat RNA-sequestration of SRSF1 triggers the NXF1-dependent nuclear export of C9ORF72 transcripts retaining expanded hexanucleotide repeats PMID: 28677678
    3. Hepatitis B virus core protein associates with the cellular NXF1-p15 complex via the nuclear export signal motif of hepatitis B virus core protein.Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the NXF1-p15 machinery. PMID: 25360769
    4. Complementary structural, biochemical and cellular techniques indicated that the formation of a symmetric RNA binding platform generated by dimerization of NXF1:NXT1 facilitates the recognition of CTE-RNA and promotes its nuclear export PMID: 25628361
    5. Gag polyprotein synthesis was decreased by NXF1 knockdown. PMID: 25212909
    6. TREX is the major complex used to recruit Nxf1 to mRNA in human cells. PMID: 22893130
    7. the organization of the NXF1 proline-tyrosine nuclear localization signal reveal unexpected redundancy in the nuclear import pathways used by NXF1. PMID: 21965294
    8. The U2AF65 protein served as an adaptor to link expanded CAG RNA to NXF1 for RNA export. PMID: 21725067
    9. The crystal structure of the RNA recognition and leucine-rich repeat motifs of TAP bound to one symmetrical half of the CTE RNA is solved. PMID: 21822283
    10. these data revealed a redox-regulated chaperone function of PDI in delivering antigenic peptides from TAP to MHC-I. PMID: 21299467
    11. Tpr plays an important role in quality control of mRNA trafficked on the Nxf1 pathway. PMID: 21613532
    12. These results showed that the interaction between herpes simplex virus type 1 ICP27 and human TAP/NXF1 occurred in living cells upon head-to-tail intramolecular association of ICP27. PMID: 21060739
    13. Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway PMID: 19924249
    14. Depletion of NXF1 or 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole treatment had similar effects, inhibiting the nuclear export of several of the H5N1 influenza virus mRNAs. PMID: 20071484
    15. The structural and mutational data define a novel RNA-binding site on the Tap protein PMID: 11854490
    16. Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1 PMID: 11875519
    17. Karyopherin beta2B is a nuclear export factor and mediates mRNA export in cooperation with TAP PMID: 12384575
    18. structural basis for interaction of UBA domain and FG nucleoporins PMID: 12581645
    19. nuclear export sequences regulate human TAP function in mRNA export by direct nuclear pore interactions PMID: 14963046
    20. hypophosphorylation of ASF in mRNPs coincides with its higher affinity for TAP PMID: 15184380
    21. SR proteins 9G8 and ASF/SF2 exhibit higher affinity for TAP/NXF1 when hypophosphorylated PMID: 15210956
    22. concluded that herpes simplex virus type 1 ICP27 and the viral RNAs to which it binds are exported via the TAP/NXF1 export receptor. PMID: 15767397
    23. results indicate that Tap regulates expression of its own intron-containing RNA through a CTE (constitutive transport element)-mediated mechanism PMID: 16971948
    24. RNA transport element RTE evolved as a high affinity RBM15 ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts PMID: 17001072
    25. evidence presented that the export factor TAP/NXF1 binds poorly to XIST RNA in comparison to exported mRNAs, suggesting that reduced TAP/NFX1 binding may contribute to nuclear retention of XIST RNA PMID: 17333237
    26. ORF57 interacts with the cellular export factor REF and with RNA, suggesting that it may provide target mRNAs with access to REF, which mediates nuclear RNA export by binding to TAP/NXF1. PMID: 17609285
    27. Homotypic Tap complex can interact with both Nxt1 and nucleoporins in vitro. PMID: 17978099
    28. The efficiency and stability of the approach are demonstrated by reconstructing the structure of a two domain region of the 31 kDa nuclear export factor TAP (TIP-associated protein). PMID: 18670889
    29. ICP27 is the major export adaptor for HSV-1 mRNA and that it links bound transcripts to the TAP/NXF1 export receptor PMID: 19019956
    30. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. PMID: 19586903
    31. oligomerization of Tap affects its interactions with nucleoporins PMID: 17978099

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Nucleus, nuclear pore complex. Nucleus envelope. Cytoplasm. Cytoplasm, Stress granule.
  • 蛋白家族:
    NXF family
  • 組織特異性:
    Expressed ubiquitously.
  • 數據庫鏈接:

    HGNC: 8071

    OMIM: 602647

    KEGG: hsa:10482

    STRING: 9606.ENSP00000294172

    UniGene: Hs.523739



主站蜘蛛池模板: 亚洲龙腾成小说人网| 亚洲欧美精品伊人久久| 欧美熟妇的性裸交| 久久久久亚洲精品天堂| 无码精品一区二区三区免费视频 | 欧美亚洲高清国产| 久久www免费人成一看片| 欧美人与禽zoz0性伦交| 免费一区二区三区成人免费视频| 亚洲一二区制服无码中字| 无码人妻一区二区三区免费手机| 狠狠色综合网丁香五月| 国产自愉自愉免费精品七区| 亚洲乱码卡一卡二卡新区仙踪木木| 国产高清在线精品二区| 欧美老熟妇xb水多毛多| 亚洲精品专区在线观看| 国产av福利久久| 永久免费观看国产裸体美女| 使劲快高潮了国语对白在线| 久久超碰精品一夜七次郎| 青草影院内射中出高潮| 真实国产乱子伦在线视频| 欧洲无码一区二区三区在线观看| 无码av波多野结衣久久| 国产成人a区在线观看| 亚洲成a人片在线观看天堂无码不卡 | 中文字日产乱码免费1~3软件| 无码精品一区二区三区免费视频| 国产伦精品免编号公布| 色爱情人网站| 欧美xxxxx在线观看| 日本一卡2卡3卡四卡精品网站| 中文在线√天堂| 国产清纯在线一区二区www| 国产午夜福利不卡在线秋霞秋霞| 狠狠色噜噜狠狠狠7777奇米| 成人毛片无码免费播放网站| 无码无套少妇18p在线直播| 国产人成视频在线观看| 久久久精品人妻一区亚美研究所|