在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUDT21 Antibody, FITC conjugated

  • 中文名稱:
    NUDT21兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA016170LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NUDT21 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NUDT21
  • 別名:
    CFIM 25 antibody; CFIM25 antibody; Cleavage and polyadenylation specific factor 5 25 kD subunit antibody; Cleavage and polyadenylation specific factor 5 25 kDa antibody; Cleavage and polyadenylation specific factor 5 antibody; Cleavage and polyadenylation specificity factor 25 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 5 antibody; Cleavage factor Im complex 25 kDa subunit antibody; CPSF 25 antibody; CPSF 25 kDa subunit antibody; CPSF 5 antibody; CPSF25 antibody; CPSF5 antibody; CPSF5_HUMAN antibody; DKFZp686H1588 antibody; Nucleoside diphosphate linked moiety X motif 21 antibody; Nucleoside diphosphate-linked moiety X motif 21 antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 21 antibody; Nudix hydrolase 21 antibody; Nudix motif 21 antibody; NUDT 21 antibody; Nudt21 antibody; Pre mRNA cleavage factor Im (25kD) antibody; Pre mRNA cleavage factor Im 25 kDa subunit antibody; Pre mRNA cleavage factor Im 25kD subunit antibody; Pre-mRNA cleavage factor Im 25 kDa subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cleavage and polyadenylation specificity factor subunit 5 protein (2-227AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides.
  • 基因功能參考文獻:
    1. Findings suggest that CFIm25 plays an important role in lung cancer cell proliferation through regulating the alternative polyadenylation (APA) of oncogenes. PMID: 29928883
    2. RNA sequence preferences of unconventional RNA-binding proteins, Nudt21 and CNBP, has been described. PMID: 27956239
    3. Loss of NUDT21 shortened the 3'-UTR of various oncogenes in hepatocellular carcinoma cells. The shorter 3'-UTR contained less miRNA binding sites, which enabled the oncogenes to evade miRNA regulation and become overexpressed in HCC, leading to unregulated cancer cell proliferation. PMID: 28964783
    4. it was demonstrated that the CFIm25 protein was also downregulated in osteosarcoma tissues, and inhibited the proliferation and promoted the apoptosis of the cells. Elucidating the roles of miR181a and CFIm25 in osteosarcoma not only assists in further understanding the pathogenesis and progression of this disease, but also offers novel targets for effective therapies. PMID: 27633853
    5. The authors identify NUDT21 as a novel candidate for intellectual disability and neuropsychiatric disease, and elucidate a mechanism of pathogenesis by MeCP2 dysregulation via altered alternative polyadenylation. PMID: 26312503
    6. Structure of a CFI(m)25/CFI(m)68 RRM heterotetramer and biochemical data indicated that CFIm25 specifically recognized two UGUA elements, CFIm68 facilitates looping of the intervening RNA. CFIm-mediated RNA looping may regulate alternative polyadnylation. PMID: 21295486
    7. Crystal structure of CFIm25-CFIm68 RRM heterotetramer illustrated that CFIm25 homodimer is clamped by two CFIm68 monomers on each side of the dimer interface. PMID: 21295486
    8. Data provide evidence that CFIm exists as a heterotetramer of 25-kD, 59-kD and 68-kD subunits of CFIm: CFIm25, CFIm59 and CFIm68. PMID: 20695905
    9. Crystallographic and biochemical experiments suggest that CF I(m)25 specifically recognizes UGUA RNA sequence and binds to two UGUA simultaneously PMID: 20479262
    10. crystal structures of the CFI(m)25 homodimer in complex with UGUAAA and UUGUAU RNA sequences PMID: 20479262
    11. region in the subunit of CF I(m) involved in RNA binding, protein-protein interactions, and subcellular localization PMID: 15169763
    12. Evidence that CFIm25 regulates alternative poly(A) site selection of genes with tandem poly(A) signals in their 3'-UTRs. PMID: 17098938
    13. Results from crystallographic and biochemical experiments suggest that CF I(m)25 makes use of its Nudix fold to bind but not hydrolyze ATP and diadenosine tetraphosphate. PMID: 18445629
    14. The crystal structure of human CPSF5 was solved at 1.9 A resolution. PMID: 18767156

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Nudix hydrolase family, CPSF5 subfamily
  • 組織特異性:
    Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 13870

    OMIM: 604978

    KEGG: hsa:11051

    STRING: 9606.ENSP00000300291

    UniGene: Hs.528834



主站蜘蛛池模板: 亚洲成a人片在线观看www| 日韩亚洲国产中文永久| 四虎永久在线精品免费一区二区| 性视频播放免费视频| 欧美野外疯狂做受xxxx高潮| 蜜臀久久99精品久久久久久做爰| 国产精品区一区二区三在线播放| 国产a∨精品一区二区三区不卡| 亚洲啪啪综合av一区| 99热门精品一区二区三区无码 | 亚洲日韩欧美国产另类综合| 欧美另类bbbxxxxx另类| 丰满的少妇xxxxx青青青| 成人免费看www网址入口| 在线观看成人年视频免费| 亚洲国产成人精品无码区一本| 麻豆传传媒久久久爱| 亚洲欧美中文字幕5发布| 久久亚洲国产精品影院| 三级全黄的视频在线观看| 亚洲a∨无码无在线观看| 亚洲国产一区二区波多野结衣| 国产成+人+综合+亚洲 欧美| 久久亚洲国产精品五月天婷| 老熟女高潮一区二区三区| 男人a天堂手机在线版| 日本一丰满一bbw| 亚洲人成网站色www| 国模裸体无码xxxx视频| 国产欧美另类精品久久久| 99久久er热在这里只有精品99 | аⅴ天堂中文在线网官网| 真实国产乱子伦精品一区二区三区| 丰满少妇高潮惨叫久久久| 顶级欧美熟妇xx| 精品久久久久久无码不卡| 国产肉丝袜视频在线观看| 亚洲精品nv久久久久久久久久| 国产97在线 | 日韩| 十八禁午夜福利免费网站| 国产精品无码无卡在线播放|