在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUDT16 Antibody

  • 中文名稱:
    NUDT16兔多克隆抗體
  • 貨號:
    CSB-PA016163GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NUDT16
  • 別名:
    FLJ31265 antibody; FLJ34034 antibody; FLJ36248 antibody; Nucleoside diphosphate-linked moiety X motif 16 antibody; NUD16_HUMAN antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 16 antibody; Nudix motif 16 antibody; NUDT 16 antibody; NUDT16 antibody; U8 snoRNA-binding protein H29K antibody; U8 snoRNA-decapping enzyme antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NUDT16
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
  • 基因功能參考文獻:
    1. hNudt16 hydrolysis of dinucleotide cap analogs and short capped oligonucleotides displayed a broader spectrum specificity than is currently known. PMID: 29483298
    2. data suggest the existence in T-ALL of a disrupted RNA decapping pathway, mediated by the DNA methylation-associated loss of NUDT16, which contributes to the natural history of the disease by stabilizing transforming factors, such as is the case of the leukemogenic protein C-MYC PMID: 28344317
    3. This study details structural and regulatory mechanisms explaining how substrates are selected for hydrolysis by human NUDT16. PMID: 26121039
    4. The RNA decapping enzyme NUDT16 selectively degrades 5'-TOP mRNAs during Rift Valley fever virus infection and this decay is triggered in response to mTOR attenuation via the translational repressor 4EBP1/2 axis. PMID: 26038567
    5. hNUDT16 can also actively cleave the mGDP cap from mRNAs in the presence of Mg(2)(+) or Mn(2)(+). PMID: 21337011
    6. Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis. PMID: 21070968
    7. NUDT16 is a (deoxy)inosine diphosphatase that may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP. PMID: 20385596
    8. X29/H29K may be the nuclear counterparts of the cytoplasmic decapping machinery, localized in specialized bodies involved in RNA decay PMID: 17567574
    9. Recombinant NUDT16, a decapping enzyme, has been crystallized. NUDT16 plays a pivotal role in U8 snoRNA stability. PMID: 18607096

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族:
    Nudix hydrolase family, NUDT16 subfamily
  • 組織特異性:
    Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain.
  • 數據庫鏈接:

    HGNC: 26442

    OMIM: 617381

    KEGG: hsa:131870

    STRING: 9606.ENSP00000422375

    UniGene: Hs.282050



主站蜘蛛池模板: 日本少妇自慰免费完整版| 人妻精品动漫h无码网站| 国产精品久久人妻互换| 欧美乱大交xxxxx疯狂俱乐部 | 久久久久成人网站| 未满十八18禁止免费无码网站| 国产伦人人人人人人性| 黑人大战日本人妻嗷嗷叫不卡视频| 波多野美乳人妻hd电影欧美| 无码av天堂一区二区三区 | 无码国模大尺度视频在线观看 | 人妻巨大乳一二三区| 伊人久久五月丁香综合中文亚洲| 麻豆果冻传媒2021精品传媒一区| 日本久久夜夜一本婷婷| 久久国语露脸国产精品电影| 国产精品福利自产拍在线观看| 99精品国产再热久久无毒不卡| 亚洲高清乱码午夜电影网| 国产熟妇另类久久久久久| 伊人精品成人久久综合97| 亚洲午夜无码久久| 东京热人妻中文无码av| 波多野结衣 黑人| 少妇熟女久久综合网色欲| 国产成人片无码视频在线观看| 狠狠色婷婷久久综合频道毛片| 日日鲁鲁鲁夜夜爽爽狠狠视频97| 国产精品乱码一区二区三区| 亚洲中文字幕日产无码成人片 | 亚洲精品一区二区不卡| 国产精品毛片在线完整版sab| 亚洲伊人久久精品影院| 男女性爽大片视频| 国产99久久亚洲综合精品西瓜tv| 欧美性大战xxxxx久久久√| 国产亚洲精品精品国产亚洲综合| 性乌克兰xxxx极品| 麻豆视传媒官网免费观看| 欧美精品videosex极品| 亚洲香蕉视频天天爽|