在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUDC Antibody

  • 中文名稱:
    NUDC兔多克隆抗體
  • 貨號:
    CSB-PA006694
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of rat cells using NUDC Polyclonal Antibody
    • Western Blot analysis of AD293 using NUDC Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NUDC
  • 別名:
    HNUDC antibody; MNUDC antibody; MNUDC protein antibody; NPD011 antibody; Nuclear distribution C homolog antibody; Nuclear distribution gene C (A.nidulans) homolog antibody; Nuclear distribution gene C homolog antibody; Nuclear distribution gene C homolog (A. nidulans) antibody; Nuclear distribution protein C homolog antibody; Nuclear migration protein nudC antibody; nudC antibody; NudC nuclear distribution protein antibody; NUDC_HUMAN antibody; OTTHUMP00000004405 antibody; SIG 92 antibody; SIG92 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human NUDC around the non-phosphorylation site of S326.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
  • 基因功能參考文獻:
    1. High expression of NUDC is associated with prostate cancer. PMID: 27959429
    2. the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
    3. NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
    4. NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
    5. Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
    6. NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
    7. separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
    8. Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
    9. functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
    10. PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
    11. Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
    12. In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
    13. NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
    14. hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
    15. hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族:
    NudC family
  • 組織特異性:
    Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
  • 數據庫鏈接:

    HGNC: 8045

    OMIM: 610325

    KEGG: hsa:10726

    STRING: 9606.ENSP00000319664

    UniGene: Hs.263812



主站蜘蛛池模板: 国产做a爱免费视频在线观看| 亚洲的天堂av无码| 国产丝袜足j在线视频播放| 女人夜夜春高潮爽a∨片传媒| 中文字幕亚洲综合久久蜜桃| 五月丁香啪啪| 国产麻豆精品久久一二三| 亚洲成h人av无码动漫无遮挡| 亚洲中文字幕无码天然素人| 在线观看无码av网站永久免费| 夜精品a片一区二区三区无码白浆| 国产乱人对白| 少妇精油按摩av无码中字| 国产精品18久久久久久欧美 | 午夜天堂av天堂久久久| 久久发布国产伦子伦精品| 亚洲精品欧美综合一区二区| 国产精品自在线拍亚洲另类| 精品卡一卡二卡3卡高清乱码| √天堂资源地址中文在线| 免费无码成人av在线播| 青青视频免费观看免费| 亚洲精品中文字幕乱码三区| 亚洲精品美女久久久久99| 日本高清在线www3344| 老熟妇乱子伦牲交视频| 天堂√最新版中文在线地址| 中文 在线 日韩 亚洲 欧美| 国产精品一区二区av交换| 真实的国产乱xxxx| 久久天天躁夜夜躁狠狠躁2022| 国产高清乱理伦片| 麻豆国产av尤物网站尤物| 在厨房拨开内裤进入毛片| 国产69精品久久久久久妇女迅雷| 纯肉无遮挡h肉动漫在线观看国产 国产精品18久久久久久欧美 | 3d动漫精品啪啪一区二区免费| 成人无码视频在线观看大全| 亚洲免费福利在线视频| 无码人妻丰满熟妇a片护士| 一区二区三区视频|