在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUCKS1 Antibody

  • 中文名稱(chēng):
    NUCKS1兔多克隆抗體
  • 貨號(hào):
    CSB-PA016147GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    NUCKS1
  • 別名:
    FLJ21480 antibody; FLJ32016 antibody; FLJ38536 antibody; JC7 antibody; NUCKS 1 antibody; NUCKS antibody; NUCKS_HUMAN antibody; Nucks1 antibody; Nuclear casein kinase and cyclin dependent kinase substrate 1 antibody; Nuclear ubiquitous casein and cyclin dependent kinases substrate antibody; Nuclear ubiquitous casein and cyclin-dependent kinases substrate antibody; Nuclear ubiquitous casein kinase and cyclin dependent kinase substrate antibody; P1 antibody; Potential LAG1 interactor antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NUCKS1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1.
  • 基因功能參考文獻(xiàn):
    1. our results suggested that there was a significant association of a minor allele (G) in rs823114 with reduced risk of Parkinson's disease development (P = 0.017, OR = 0.768, 95%CI = 0.618 - 0.955). We conclude that NUCKS1 rs823114 indicates a decreased risk of susceptibility to Parkinson's disease and shows a male genetic distribution bias in the Han Chinese population. PMID: 29607885
    2. High NUCKS1 expression is associated with drug resistance in lung cancer. PMID: 26989074
    3. NUCKS overexpression had prognostic potential for overall survival and disease-free survival in advanced ovarian cancers and only for disease-free survival in early ovarian cancers . Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer PMID: 28877654
    4. NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC PMID: 26968889
    5. The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression. PMID: 26323318
    6. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators. PMID: 24931609
    7. NUCKS1 expression did not increase Tat nuclear localization. PMID: 25116364
    8. NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma PMID: 24819170
    9. NUCKS-1 overexpression is associated with obesity and with breast cancer. PMID: 24568505
    10. We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67, thus allowing more precise assessment of tumor proliferation potential. PMID: 25119009
    11. Authors suggest that NUCKS is involved in cellular responses following PDT. PMID: 24284105
    12. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis. PMID: 24140890
    13. Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer. PMID: 23065711
    14. The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression. PMID: 19664271
    15. Overexpression of NUCKS can play significant role in breast cancer biology. PMID: 20069058
    16. Two putative nuclear localization signals have been identified and characterized in NUCKS. PMID: 17604136
    17. NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described. PMID: 18491381

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Chromosome.
  • 組織特異性:
    Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 29923

    OMIM: 611912

    KEGG: hsa:64710

    STRING: 9606.ENSP00000356110

    UniGene: Hs.213061



主站蜘蛛池模板: 日本牲交大片无遮挡| 白又丰满大屁股bbbbb| 亚洲精品av中文字幕在线| 亚洲精品久久一区二区三区四区 | 男女做爰真人视频直播| 色婷婷久久一区二区三区麻豆| 亚洲中文字幕永久在线全国| 粉嫩小泬视频无码视频软件| 国产99久久精品一区二区| 亚洲国产丝袜精品一区| 99久久久国产精品消防器材 | 久久不见久久见中文字幕免费 | 免费一区二区三区成人免费视频| 精国产品一区二区三区a片| 成人做爰100部片免费下载| 曰本一道本久久88不卡| 亚洲另类色区欧美日韩图片| 熟女人妻aⅴ一区二区三区60路| 中文字幕乱妇无码av在线| 99久久无色码中文字幕| 国产精品一区二区手机在线观看 | 国产精品国产三级国产aⅴ下载| 久久香综合精品久久伊人| av无码久久久久不卡网站下载| 人妻无码久久一区二区三区免费| 亚洲va久久久噜噜噜久久| 无码国产精品一区二区免费vr | 人人妻人人澡人人爽国产| 日韩高清在线观看永久| 欧美日韩在大午夜爽爽影院| 国精品无码人妻一区二区三区| 在线观看无码不卡av中文| 久久久精品人妻一区二区三区gv | 欧美性色老妇人| 国产亚洲精品俞拍视频| av无码小缝喷白浆在线观看| 国产美女精品自在线拍免费| 97久久人人超碰国产精品| 国产精品福利一区二区| 日本高清aⅴ毛片免费| 硬了进去湿好大娇喘视频|