在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NUB1 Antibody

  • 中文名稱:
    NUB1兔多克隆抗體
  • 貨號:
    CSB-PA016141GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    NUB1
  • 別名:
    BS4 antibody; NEDD8 ultimate buster 1 antibody; Negative regulator of ubiquitin like proteins 1 antibody; Negative regulator of ubiquitin-like proteins 1 antibody; NUB1 antibody; NUB1_HUMAN antibody; NUB1L antibody; NY REN 18 antibody; NYREN18 antibody; Renal carcinoma antigen NY-REN-18 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NUB1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
  • 基因功能參考文獻:
    1. Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159. PMID: 28099510
    2. data suggest that NUB1 participates in telomere maintenance by regulating the levels of TRF1 at telomeres through both NEDD8-dependent and NEDD8-independent pathways. PMID: 27214791
    3. NUB1L suppresses atypical neddylation and promotes the degradation of misfolded proteins by the proteasome PMID: 26260793
    4. Based on biochemical features of the VBM motifs, we also identified NUB1L (NEDD8 ultimate buster-1 long) as a novel VBM-containing protein, which is involved in proteasomal degradation of NEDD8 through the P97 pathway. PMID: 24100225
    5. In coordination with the P97-UFD1-NPL4 complex (P97(UFD1/NPL4)), NUB1L promotes transfer of NEDD8 to proteasome for degradation. PMID: 24019527
    6. This study identified genes modifying endogenous mHTT using high-throughput screening and demonstrate NUB1 as an exemplar entry point for therapeutic intervention of Huntington's disease. PMID: 23525043
    7. Data propose that NUB1, by regulating GSK3beta levels, modulates tau phosphorylation and aggregation, and is a key player in neurodegeneration associated with tau pathology. PMID: 22965877
    8. In the present study, the proportions of intranuclear inclusion positive for NEDD8, NUB1 and SUMO-1 were significantly lower in glial cells than in neurons. PMID: 22612509
    9. The finding of this study suggested that NUB1 along with abnormal alpha-synuclein is involved in the pathogenesis of Lewy body disease. PMID: 21937912
    10. NUB1 has a splicing variant, NUB1L, which regulates the NEDD8 conjugation system PMID: 12816948
    11. These results imply that the ubiquitin precursor UbC1 hydrolysis mediated by NEDD8 ultimate buster-1 (NUB1) is involved in cellular functions in the seminiferous tubules such as spermatogenesis. PMID: 15009209
    12. NUB1L not only acts as a linker between the 26 S proteasome and ubiquitin-like proteins, but also as a facilitator of proteasomal degradation. PMID: 16707496
    13. These results suggest that NUB1 indeed targets synphilin-1 to the proteasome for its efficient degradation, which, because of the resultant reduction in synphilin-1, suppresses the formation of synphilin-1-positive inclusions. PMID: 16877356

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Predominantly nuclear.
  • 組織特異性:
    Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17623

    OMIM: 607981

    KEGG: hsa:51667

    STRING: 9606.ENSP00000457628

    UniGene: Hs.647082



主站蜘蛛池模板: 插插插精品亚洲一区| 国产精品无码久久久久久久久久| 欧美亚洲国产成人一区二区三区| 免费全部高h视频无码| 伊伊人成亚洲综合人网| 四虎成人精品永久在线视频| 中文字幕网伦射乱中文| 18禁女裸乳扒开免费视频| 极品美女在线观看免费直播| 97se狠狠狠狠狼鲁亚洲综合色| 性色香蕉av久久久天天网| 国产精品成人av片免费看| 精品国产综合区久久久久久| 亚洲综合电影小说图片区| 亚洲美女被黑人巨大在线播放| 欧洲亚洲精品久久久久| 暖暖 免费 高清 日本 在线| 国产白丝精品爽爽久久久久久蜜臀| 99精品无人区乱码1区2区3区| 18禁在线永久免费观看| 老司机无码精品a| 国产超碰人人做人人爱一二区视品| 特级做a爰片毛片免费看| 初尝人妻少妇中文字幕| 中文字幕人妻熟女人妻a片| 久久亚洲日韩av一区二区三区| 国产精品麻豆成人av电影艾秋 | 日韩精品无码一区二区三区视频 | 国产精品人妻久久久久| 搡老岳熟女国产熟妇| 国产免费人成视频尤勿视频| 成人看片黄a免费看| 午夜天堂av天堂久久久| 性生交大片免费看l| av片日韩一区二区三区在线观看| 毛片无码免费无码播放| 性人久久网av| 久久国内精品自在自线观看| 国产一区二区三区精品视频| 色一情一乱一伦一区二区三区日本| 欧洲精品欧美精品|