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NT5C3A Antibody

  • 中文名稱:
    NT5C3A兔多克隆抗體
  • 貨號:
    CSB-PA867122DSR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA867122DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA867122DSR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NT5C3A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NT5C3A
  • 別名:
    5NT3A_HUMAN antibody; cN III antibody; cN-III antibody; cNIII antibody; Cytosolic 5' nucleotidase 3 antibody; Cytosolic 5' nucleotidase III antibody; Cytosolic 5''-nucleotidase 3 antibody; Cytosolic 5''-nucleotidase 3A antibody; Cytosolic 5''-nucleotidase III antibody; NT5C3 antibody; Nt5c3a antibody; p36 antibody; P5''N-1 antibody; P5'N 1 antibody; P5'N1 antibody; P5N 1 antibody; P5N-1 antibody; P5N1 antibody; PN I antibody; PN-I antibody; PNI antibody; PSN1 antibody; Pyrimidine 5' nucleotidase 1 antibody; Pyrimidine 5''-nucleotidase 1 antibody; UMPH antibody; UMPH1 antibody; Uridine 5' monophosphate hydrolase 1 antibody; Uridine 5''-monophosphate hydrolase 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cytosolic 5\'-nucleotidase 3A protein (37-336AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
  • 基因功能參考文獻:
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that NT5C3A is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients PMID: 27381654
    3. Pyrimidine-5'-nucleotidase Campinas is a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase type I deficiency. PMID: 25153905
    4. Results show that NT5C3 expression levels were significantly increased in patients with risk allele homozygote. PMID: 25000516
    5. New missense homozygous mutation (Q270Ter) in the pyrimidine 5' nucleotidase type I-related gene in two Indian families with hereditary non-spherocytic hemolytic anemia. PMID: 23139015
    6. All investigated mutant proteins display impaired catalytic properties and/or reduced thermostability, providing a rationale for the pathological effects of the mutations. PMID: 15604219
    7. These data highlight hUMP1/POMP role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system. PMID: 17349762
    8. 3 newly described missense mutations (c.187T>C, c.469G>C & c.740T>C) identified in patients with hemolytic anemia were characterized at protein level; the enzymes were altered in both thermal stability and catalytic efficiency PMID: 18499901
    9. genetic variation in NT5C3 might affect protein function and potentially influence drug response PMID: 19623099

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  • 相關疾病:
    P5N deficiency (P5ND)
  • 亞細胞定位:
    Cytoplasm.; [Isoform 2]: Endoplasmic reticulum.
  • 蛋白家族:
    Pyrimidine 5'-nucleotidase family
  • 組織特異性:
    Isoforms 1, 3 and 4 are expressed in reticulocytes. Isoform 4 is hardly detectable in bone marrow and fetal liver.
  • 數據庫鏈接:

    HGNC: 17820

    OMIM: 266120

    KEGG: hsa:51251

    STRING: 9606.ENSP00000242210

    UniGene: Hs.487933



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