在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NSMCE2 Antibody, Biotin conjugated

NSMCE2 Antibody, Biotin conjugated

  • 中文名稱：
    NSMCE2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA836260LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NSMCE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NSMCE2
  • 別名：
    C8orf36 antibody; E3 SUMO-protein ligase NSE2 antibody; hMMS21 antibody; hNSE2 antibody; methyl methanesulfonate sensitivity gene 21 antibody; MMS21 antibody; MMS21 homolog antibody; non-SMC element 2 antibody; Non-SMC element 2 homolog antibody; Non-structural maintenance of chromosomes element 2 homolog antibody; NSE2 antibody; NSE2_HUMAN antibody; Nsmce2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 SUMO-protein ligase NSE2 protein (1-247AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
  • 基因功能參考文獻：
    1. Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand breaks. PMID: 27792189
    2. our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia. PMID: 25245984
    3. support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress PMID: 25105364
    4. show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1 PMID: 22751501
    5. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex. PMID: 21550342
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20460480
    8. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells PMID: 16055714
    9. MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6. PMID: 19502785
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19549807
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 18163389

    顯示更多

    收起更多

  • 相關疾病：
    Seckel syndrome 10 (SCKL10)
  • 亞細胞定位：
    Nucleus. Chromosome, telomere. Nucleus, PML body.
  • 蛋白家族：
    NSE2 family
  • 數據庫鏈接：

    HGNC: 26513

    OMIM: 617246

    KEGG: hsa:286053

    STRING: 9606.ENSP00000287437

    UniGene: Hs.388297



主站蜘蛛池模板： 日韩一区精品视频一区二区| 一本加勒比波多野结衣| 亚洲精品一区久久久久一品av| 国产亚洲精品久久久久久久久动漫| 欧美v亚洲v日韩v最新在线| 少妇暴力深喉囗交3p| 亚洲男人的天堂网站| 亚洲精品一品区二品区三区| 精品一区二区三区国产在线观看| 亚洲色播永久网址大全| 欧美毛多水多肥妇| 一本大道无码人妻精品专区| 日本免费视频| 久久中文精品无码中文字幕| 日本韩国亚洲欧美在线| 国产精品无码dvd在线观看| 丝袜 亚洲 另类 欧美 变态| а天堂中文官网| 99在线精品免费视频九九视| 久久永久免费专区人妻精品| 亚洲伊人久久成人综合网| 久久成人国产精品| 一区二区三区无码被窝影院| 西西人体大胆午夜啪啪| 亚洲国产精品一区二区动图| 亚欧成人无码av在线播放| 欧美大荫蒂毛茸茸视频| 国模裸体无码xxxx视频| 色婷婷我要去我去也| 亚洲国产精品无码av| 131美女爱做视频免费| 国产免费内射又粗又爽密桃视频 | 午夜精品久久久久久久喷水| 欧美激情内射喷水高潮| 亚洲国产av天码精品果冻传媒| 国产成年女人特黄特色毛片免| 大胆欧美熟妇xx| 亚洲欧美丝袜精品久久 | 国产区在线观看成人精品| 99久久精品费精品国产一区二区| 国产白袜脚足j棉袜在线观看|