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  4. NSMAF Antibody

NSMAF Antibody

  • 中文名稱：
    NSMAF兔多克隆抗體
  • 貨號：
    CSB-PA856416LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA856416LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA856416LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NSMAF Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NSMAF
  • 別名：
    NSMAF antibody; FANProtein FAN antibody; Factor associated with neutral sphingomyelinase activation antibody; Factor associated with N-SMase activation antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein FAN protein (1-233AA )
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NSMAF Antibody (CSB-PA856416LA01HU)，的標記方式是Non-conjugated。對于NSMAF Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA856416LB01HU NSMAF Antibody, HRP conjugated ELISA
    FITC CSB-PA856416LC01HU NSMAF Antibody, FITC conjugated
    Biotin CSB-PA856416LD01HU NSMAF Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
  • 基因功能參考文獻：
    1. these data identify a novel caspase-2-interacting factor, FAN, and expand the role for the enzyme in seemingly non-apoptotic cellular mechanisms. PMID: 29621545
    2. The rs1050504 C > T genotype was observed to be significantly associated with an increased risk for developing pulmonary tuberculosis. PMID: 29115933
    3. The interaction of FAN with receptor for activated C-kinase 1 (RACK1) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN. PMID: 12391233
    4. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase PMID: 15653433
    5. Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells. PMID: 18653803

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  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 8017

    OMIM: 603043

    KEGG: hsa:8439

    STRING: 9606.ENSP00000411012

    UniGene: Hs.372000



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