在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NRF1 Antibody

  • 中文名稱:
    NRF1兔多克隆抗體
  • 貨號:
    CSB-PA122920
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane: Hela cells, Primary antibody: CSB-PA122920(NRF1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    alpha pal antibody; alpha palindromic binding protein antibody; Alpha palindromic-binding protein antibody; Alpha-pal antibody; locus control region factor 1 antibody; NFE2 related factor 1 antibody; NRF-1 antibody; Nrf1 antibody; NRF1_HUMAN antibody; Nuclear respiratory factor 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human NRF1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
  • 基因功能參考文獻:
    1. CB-5083 decreases viability in multiple myeloma cell lines and patient-derived multiple myeloma cells, including those with background proteasome inhibitor (PI) resistance. CB-5083 has a unique mechanism of action that combines well with PIs, which is likely owing to the p97-dependent retro-translocation of the transcription factor, Nrf1, which transcribes proteasome subunit genes following exposure to a PI PMID: 28878026
    2. Chronic kidney disease patients undergoing hemodialysis might be subjected to potential mitochondrial oxidative dysregulation and NRF1 down-regulation. PMID: 28164673
    3. this study therefore identifies NRF-1 as a novel regulator of HIF-1a. PMID: 27491637
    4. NRF-1 and its target mitochondrial transcription factor A (TFAM) were higher in Tamoxifen (TAM)-resistant LCC2 and LCC9 cells than TAM-sensitive MCF-7 cells. PMID: 27515002
    5. NRF1 overexpression attenuated BPDEinduced Sphase arrest via the ATM/Chk2 signaling pathway. PMID: 27035420
    6. Low NRF1 expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma. PMID: 26201446
    7. EglN2 associates with the NRF1-PGC1alpha complex and controls mitochondrial function in breast cancer PMID: 26492917
    8. We show that composite nucleosomes containing mH2A and NRF-1 are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses PMID: 25959814
    9. Results present evidence in the support of E2-induced ROS-mediated AKT signalling leading to the activation of NRF-1-regulated cell cycle genes. PMID: 25965299
    10. This study identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation. PMID: 25792330
    11. The mitochondria targeting sequence-deficient hTFAM also repressed Tfam promoter activity to the same degree as hTFAM. PMID: 24875355
    12. Low NRF1 expression is associated with chronic kidney disease after dialysis. PMID: 24204994
    13. We verified that NRF-1 positively regulates FAM134C and ENOX1, and negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. PMID: 23939472
    14. NRF-1 regulates Atp1a1 and Atp1b1 and are important in mediating the energy generation and neuronal activity. PMID: 23048038
    15. APE1 is a new coactivator of NRF1, demonstrating an additional regulatory role of APE1 in maintenance of mitochondrial functionality. PMID: 22580151
    16. Given that NRF-1 is a key nuclear transcription factor regulating genes involved in mitochondrial activity and biogenesis, these data suggest that diesel exhaust particulate extracts may adversely affect mitochondrial function. PMID: 22105178
    17. Single nucleotide polymorphism in NRF1 gene is associated with epithelial ovarian cancer. PMID: 21447778
    18. Upon IMS stress, overproduction of reactive oxygen species (ROS) and phosphorylation of AKT triggers estrogen receptor (ER) activity, which further upregulates the transcription of the mitochondrial regulator NRF1 and the IMS protease HTRA2. PMID: 21486948
    19. Both NRF-1 and GABP have been linked to the regulation of nuclear-encoded mitochondrial proteins, and the results of this study suggest their expression is coordinated by NRF-1's activation of the GABPbeta promoter. PMID: 21609478
    20. Data demonstrated that the polymorphism in TP53 (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (rs1882095) increased the risk of type 2 diabetes. PMID: 21146886
    21. Findings indicate that TLR4-dependent NFkappaB and CREB activation co-regulate the NRF1 promoter with NFkappaB intronic enhancement and redox-regulated nuclear translocation, leading to downstream target-gene expression. PMID: 20587593
    22. Taken together, these results confirm the direct interaction of NRF-1 and ERR alpha with PGC-1 beta, and their participation in mitochondrial biogenesis and respiration. PMID: 20561910
    23. the obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 PMID: 20724482
    24. This study demonstrates that NRF-1 is a novel transcriptional inhibitor of the human ACCbeta gene promoter in the mammalian heart. PMID: 20599696
    25. Effect of gene on proliferation arrest in a non-small cell bronchopulmonary cancer line. PMID: 12174908
    26. Insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 (NRF-1)-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function PMID: 12832613
    27. Overexpression of human nuclear respiratory factor 1 in transgenic mice increases glucose transport capacity in skeletal muscle. PMID: 12958173
    28. alpha-Pal/NRF-1 is an essential transcription factor in the regulation of human IAP gene expression PMID: 14747477
    29. specifically binds the 21-bp minimal promoter and positively contributes to transcription of the X gene of Hepatitis B virus. PMID: 15452206
    30. These findings indicate that a novel function of alpha-Pal/NRF-1 is to regulate neuronal differentiation, and that this function is mediated partly via its downstream IAP gene. PMID: 15992771
    31. There is an association between NRF-1 genotypes (rs2402970 and rs6949152 polymorphisms) and the baseline and/or training response of human aerobic capacity. PMID: 18184751
    32. These findings support a role for MEF2A as an intermediary in coordinating respiratory chain subunit expression in heart and muscle through a NRF1 --> MEF2A --> COX(H) transcriptional cascade. PMID: 18222924
    33. results reveal that especially NRF-1, along with AP-1 and, to a minor extent, an Sp1 site, is essential for human CAPNS1 promoter activity and gene expression PMID: 18234454
    34. Data show that NRF-1 is the main transcription factor regulating the expression of TOMM34, and that Sp1 interacts with NRF-1 to stimulate the promoter's full activity. PMID: 18364745
    35. No differences in mRNA levels of genes which mediate the transcriptional of mitochondrial biogenesis (PPARGC1A and NRF1) or in mitochondrial mass between diabetic and control myotubes. PMID: 18719883
    36. NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex. PMID: 19181665
    37. Deletion and site-directed mutagenesis combined with in silico transcription factor binding analysis of VSNL1 promoter identified nuclear respiratory factor (NRF)-1/alpha-PAL as a major player in regulating VSNL1 minimal promoter activity. PMID: 19674972
    38. Fig 2B describes a putative bZIP motif; however, this peptide sequence has no sequence similarity to the conserved smart00338:BRLZ or pfam03131:bZIP_Maf protein domains. PMID: 8034649
    39. The authors incorrectly use the symbol NFE2L1; this publication discusses nuclear respiratory factor 1 which has an official symbol of NRF1. PMID: 7558044

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    NRF1/Ewg family
  • 組織特異性:
    Ubiquitously expressed with strongest expression in skeletal muscle.
  • 數據庫鏈接:

    HGNC: 7996

    OMIM: 600879

    KEGG: hsa:4899

    STRING: 9606.ENSP00000223190

    UniGene: Hs.654363



主站蜘蛛池模板: 无码国产精品成人| 18禁免费无码无遮挡不卡网站| 四虎免费大片aⅴ入口| 亚洲国产精品无码久久久久高潮 | 亚洲午夜无码久久| 日本熟妇浓毛hdsex| 熟妇人妻久久中文字幕| 黄在线看片免费人成视频 | 国产精品视频一区二区三区无码| 99久久免费国产精品四虎| 2020国产激情视频在线观看| 欧美xxxx做受欧美88| 国产精品美女久久久久久久久| www国产精品内射老熟女| 亚洲电影天堂av2017| 国精品99久9在线 | 免费| 日本xxx在线观看免费播放| 国产综合久久久久久鬼色| 欧洲精品99毛片免费高清观看| 欧美国产日韩a在线视频| 中国熟妇毛多多裸交视频| 亚洲欧洲无码av一区二区三区| 拍真实国产伦偷精品| 国产一区二区精品丝袜| 国产高清亚洲精品视bt天堂频| 欧美综合精品久久久久成人影院 | 无码国产一区二区免费| 国模小黎自慰gogo人体| 久久亚洲精品中文字幕| 最近中文字幕免费大全在线| 亚洲伊人久久精品影院| 99视频偷窥在线精品国自产拍| 国产人妻久久精品二区三区特黄| 中文字幕奈奈美被公侵犯| 熟女人妻av完整一区二区三区| 国产精品久久久久久超碰 | 久久综合给合久久狠狠狠97色69 | 国产午夜亚洲精品不卡| 亚洲一线产区二线产区分布| 国产免费踩踏调教视频| 久久天天躁夜夜躁狠狠85麻豆|